2016年参加美国第39届休克年会,获得“Travel Award”
"Travel Award" at the 39th Annual Conference on Shock 2016-Austin, Texas, U.S.A
主持或参加科研项目(课题)及人才计划项目情况:
国家自然科学青年基金项目,81800081,PD-L1/CD80调节肺微血管内皮细胞糖代谢在脓毒症致急性肺损伤中的作用机制研究,负责人
美高梅基础研究能力提升计划,1507219058,PD-L1/CD80分子交联调节肺血管内
皮细胞屏障功能在急性肺损伤中的作用研究,负责人
代表性研究成果
(1)Shumin Xu , Qian Yang, Jianwen Bai, Tianzhu Tao, Lunxian Tang, Yaping Chen, Chun-Shiang Chung , Eleanor A Fallon , Alfred Ayala,Blockade of Endothelial, but Not Epithelial, Cell Expression of PD-L1 Following Severe Shock Attenuates the Development of Indirect Acute Lung Injury in Mice ,Am J Physiol Lung Cell Mol Physiol ,2020 Apr 1;318(4):L801-L812. doi: 10.1152/ajplung.00108.2019. Epub 2020 Jan 29.
(2)孙冰珂,李秀华,郑贵珍,董天操,李玉生,李红强,燕艳丽,白建文,许淑敏,基于肺微血管内屏细胞而非肺上皮细胞途径阻断PD-L1表达可以减轻小鼠的间接急性肺损伤,中华危重病急救杂志,2019.01;31(1):37-43
(3)Hongqiang Li#, Runv Zhou#, Chunmei Wang, Yusheng Li, Guizhen Zheng, Sen Jiang, Tiancao Dong, Jianwen Bai*, Shumin Xu*,T follicular regulatory cells infiltrate the human airways during the onset of acute respiratory distress syndrome and regulate the development of B regulatory cells,Immunol Res (2018) 66:548-554;
(4)Shumin Xu#, Mingzheng Xu(#), Guanggang Li, Chunmei Wang, Haihan Song, Jianwen Bai *, Early Recruitment of IL-10-Producing B Cells Into Alveoli Improved the Resolution of Acute Lung Injury, Cell Physiol Biochem, 2016.01.01, 38(5): 1752~60
(5)Shumin Xu, Jianwen Bai, Tianzhu Tao, Yaping Chen, Chunshiang Chung, Ayala Alfred, Blockade Of Programmed Death-Ligand1 (PD-L1) Attenuates Shock/Sepis Induced Acute Lung Injury Through Targeting Endothelial Cells But Not Epithelial Cells, Thirty-Ninth Annual Conference on Shock, Austin, Texas, 2016.06.11-2016.06.14 (会议报告)
(6) Xiandong Liu, Sen Jiang, Qian Zhang, Xiaowei Bao, Wei Cao, Shumin Xu, Jianwen Bai, Lunxian Tang, Tim-3 Regulates Tregs’ Ability To Resolve The Inflammation And Proliferation Of Acute Lung Injury By Modulating Macrophages Polarization, shock, 2017.11, 2017 (期刊论文)
(7)Yujia Zhou, Lunxian Tang, Minjia Lin, Shumin Xu, Jianwen Bai *, Haihan Song *, Expression of Cytotoxic T-Lymphocyte Antigen 4 on CD4+and CD8+TCells Is Increased in Acute Lung Injury , DNA AND CELL BIOLOGY, 2013.12, 32(12): 722~726
(8)Haihan Song#, Jianjun Xi#, Guang-Gang Li, Chunmei Wang, Shumin Xu, Tingting Cheng, Hongiang Li, Ying Zhang, Xiandong Liu, Jianwen Bai*, Upregulation of CD19+CD24+hiCD38+hi regulatory B cells is associated with a reduced risk of acute lung injury in elderly pneumonia patients, Internal and Emergency Medicine,2016.04;11(3):415-23
(9)许淑敏 # ; 李红强#; 林闽加; 鄂红玉; 程婷婷; 白建文, 高龄肺炎患者中性粒细胞 TLR4 表达与临床意义, 美高梅学报(医学版), 2013.01.01, 34(6): 21~25
(10)Hongqiang Li#, Shumin Xu#, Tingting Cheng, Lunxian Tang, Jianwen Bai*; Minjia Lin* ,Effects of Traditional Chinese Medicine Fu Zheng Decoction on the Immunological Function and Clinical Prognosis of the Elderly Patients with Pneumonia, Cell Biochemistry and Biophysics, 2015.01.01, 71(1): 34~41
(11)Haihan Song, Lunxian Tang, Mingzheng Xu, Hongqiang Li, Shumin Xu, Guanggang Li, Xiaowei Bao, Bingke Sun, Tingting Cheng, QianYang, Bai,Jianwen, CD86 Polymorphism Affects Pneumonia-Induced Sepsis by Decreasing Gene Expression in Monocytes , INFLAMMATION, 2015.4, 38(2): 879~885
(12) Jianwen Bai#, Haihan Song#, Chen Cai, Meiyan Zhang, Shumin Xu, Jun Tan, The Association of Monocyte Chemotactic Protein-1 and CC Chemokine Receptor 2 Gene Variants with Chronic Obstructive Pulmonary Disease , DNA AND CELL BIOLOGY, 2012.6, 31(6): 1058~1063