主持或参加科研项目(课题)及人才计划项目情况:
1.国家自然科学基金青年项目,81702842,lncRNA GAS5抑制胃癌转移机制的探讨,20万,主持,国家级
2.上海市科学技术委员会扬帆计划,17YF1415000,lncRNA GAS5调控p53蛋白抑制胃癌发生发展机制的探讨,20万,主持,省部级
3.美高梅附属第十人民医院攀登人才计划,优秀青年医师A类,lncRNAs作为识别早期脓毒症分子标志物的研究,8万,负责人,院级
4.国家自然科学基金面上项目,81871540 ,lncRNA GAS5调控自噬在脓毒症性心肌损伤中的作用,57万,主要参与,国家级
5.上海市卫计委重要薄弱学科建设计划,2016ZB0204-01,lncRNA在脓毒症发生发展中的作用及其机制探讨,20万,主要参与,省部级
6.住友制药横向课题,05.06.17.005,耐药肺炎克雷伯菌药物体外联合治疗方案研究,10万,参与,横向课题
7.上海市自然科学基金课题,18ZR1429500,Ppif基因敲除抑制脓毒症性心肌损伤的研究,20万元,主要参与,省部级
Presiding over or participating in scientific research projects and talent projects:
1. National Natural Science Foundation Youth Project, 81702842, Inhibition of Gastric Cancer Metastasis by lncRNA GAS5
2. Shanghai Science and Technology Commission's Sailing Plan, 17YF1415000, lncRNA GAS5 Regulating p53 Protein Inhibiting the Occurrence and Development of Gastric Cancer, provincial and ministerial level
3. The Tenth People's Hospital Affiliated to Tongji University Climbing Talents Program, Excellent Young Physicians Class A, lncRNAs as Molecular Markers for Recognition of Early Sepsis, college level
4. National Natural Science Foundation Project, 8187 1540, the role of lncRNA GAS5 in regulating autophagy in septic myocardial injury
5. Construction Plan of Important Weak Disciplines of Shanghai Medical Planning Commission, 2016ZB0204-01, the Role of lncRNA in the Occurrence and Development of Sepsis and Its Mechanisms
6. Sumitomo Pharmaceutical Horizontal Subject, 05.06.17.005, Research on Drug-Resistant Klebsiella Pneumoniae Combined Therapy in Vitro
7. Shanghai Natural Science Foundation Project, 18ZR1429500, Ppif gene knockout inhibition of septic myocardial injury research
代表性著作(均为第一作者或者并列第一作者)
代表性论著(均为第一作者或者并列第一作者)
1.Yongchao Liu, Nuer Maimaiti Abula, QixingWang, Nana Tong, Xiangyu Zhang, Aisikaer Aisha, Sheng Wang: Effect of external diaphragmatic pacing therapy on patients with chronic cor pulmonale: a randomized, controlled trial. J Int Med Res 2020, 48(11):300060520965839.
2.Yongchao Liu, Lu Yin, Chunqiu Chen, Xiangyu Zhang, Sheng Wang: Long non-coding RNA GAS5 inhibits migration and invasion in gastric cancer via interacting with p53 protein. Dig Liver Dis 2020, 52(3):331-338.
3.Chengbao Li, Yongchao Liu, Jing Qin, Yuhao Liu, Lijie Ma, Shouqin Zhang, Junjie Wang, Sheng Wang. Profiles of differentially expressed long noncoding RNAs and messenger RNAs in the myocardium of septic mice. Ann Transl Med, 2021. 9(3): p. 199.
4.Yongchao Liu,Jing Zhao,Wenhong Zhang,Jun Gan,Chengen Hu,Guangjian Huang,Ying Zhang,lncRNA GAS5 enhances G1 cell cycle arrest via binding to YBX1 to regulate p21 expression in stomach cancer,Scientific Reports,2015.5.11,5(10159)
5.Jing Zhao,Yongchao Liu,Wenhong Zhang,Zhongwen Zhou,Jing (#) Wu,Peng Cui,Ying Zhang,Guangjian Huang,Long non-coding RNA Linc00152 is involved in cell cycle arrest,apoptosis, epithelial to mesenchymal transition, cell migration and invasion ingastric cancer,Cell Cycle,2015.10.2,14(19):3112~3123
6.Jing Zhao,Yongchao Liu,Guangjian Huang,Peng Cui,Wenhong Zhang,Ying Zhang,Long non-coding RNAs in gastric cancer: versatile mechanisms and potential for clinical translation,Am J Cancer Res, 2015.02.15,5(3):907-927
7.Yongchao Liu,Jing Zhao,Chengen Hu,Jun Gan,Wenhong Zhang,Gua ngjian Huang,Comprehensive analysis of vascular endothelial growth factor-C relatedfactors in stomach cancer,Asian Pac J Cancer Prev,2014.01.01,15(5):1925~1929
8.Yongchao Liu,Bingde Yin,Changcun Zhang,Libin Zhou,Jie Fan,Hsa-let-7a functions as a tumor suppressor in renal cell carcinoma celllines by targeting c-myc,Biochem Biophys Res Commun,2012.1.6,417(1):371~375
Representational works (all as the first author or co-author):
1.Yongchao Liu, Nuer Maimaiti Abula, QixingWang, Nana Tong, Xiangyu Zhang, Aisikaer Aisha, Sheng Wang: Effect of external diaphragmatic pacing therapy on patients with chronic cor pulmonale: a randomized, controlled trial. J Int Med Res 2020, 48(11):300060520965839.
2.Yongchao Liu, Lu Yin, Chunqiu Chen, Xiangyu Zhang, Sheng Wang: Long non-coding RNA GAS5 inhibits migration and invasion in gastric cancer via interacting with p53 protein. Dig Liver Dis 2020, 52(3):331-338.
3.Chengbao Li, Yongchao Liu, Jing Qin, Yuhao Liu, Lijie Ma, Shouqin Zhang, Junjie Wang, Sheng Wang. Profiles of differentially expressed long noncoding RNAs and messenger RNAs in the myocardium of septic mice. Ann Transl Med, 2021. 9(3): p. 199.
4.Yongchao Liu,Jing Zhao,Wenhong Zhang,Jun Gan,Chengen Hu,Guangjian Huang,Ying Zhang,lncRNA GAS5 enhances G1 cell cycle arrest via binding to YBX1 to regulate p21 expression in stomach cancer,Scientific Reports,2015.5.11,5(10159)
5.Jing Zhao,Yongchao Liu,Wenhong Zhang,Zhongwen Zhou,Jing (#) Wu,Peng Cui,Ying Zhang,Guangjian Huang,Long non-coding RNA Linc00152 is involved in cell cycle arrest,apoptosis, epithelial to mesenchymal transition, cell migration and invasion ingastric cancer,Cell Cycle,2015.10.2,14(19):3112~3123
6.Jing Zhao,Yongchao Liu,Guangjian Huang,Peng Cui,Wenhong Zhang,Ying Zhang,Long non-coding RNAs in gastric cancer: versatile mechanisms and potential for clinical translation,Am J Cancer Res, 2015.02.15,5(3):907-927
7.Yongchao Liu,Jing Zhao,Chengen Hu,Jun Gan,Wenhong Zhang,Gua ngjian Huang,Comprehensive analysis of vascular endothelial growth factor-C relatedfactors in stomach cancer,Asian Pac J Cancer Prev,2014.01.01,15(5):1925~1929
8.Yongchao Liu,Bingde Yin,Changcun Zhang,Libin Zhou,Jie Fan,Hsa-let-7a functions as a tumor suppressor in renal cell carcinoma celllines by targeting c-myc,Biochem Biophys Res Commun,2012.1.6,417(1):371~375