针对脓毒症肺损伤进行了系列基础和临床研究,在脓毒症内皮损伤机制方面提出了新颖的机制;在心肺脑复苏方面开展系列动物和临床研究,对心肺复苏预后的影响因素和心肺复苏预后预测生物标志物方面提出了较为新颖的观点;针对肠菌移植在重症感染患者中的应用展开了系列研究。近几年主要相关科研成果如下:
一、期刊论文(“#”为共同第一作者,“*”为通讯作者)
1)Si H#, Chen Y#, Jiang K, Ma K, Ramsey E, Oakey J*, Sun M*, Jiang Z*: Deterministic Single-Cell Encapsulation in PEG Norbornene Microgels for Promoting Anti-Inflammatory Response and Therapeutic Delivery of Mesenchymal Stromal Cells. Adv Healthc Mater 2024, 13(14):e2304386.
2)Zhao J#, Zhou SQ#, Chen YX#, Pan X, Chen YZ*, Zhuang YG*: Causal Relationship between Mitochondrial-Associated Proteins and Sepsis in ICU Patients: A Mendelian Randomization Study. ACS Omega 2024, 9(7):8457-8463.
3)Liu D#, Zhao J#, Xia H, Dong S, Yan S, Zhuang Y, Chen Y*, Peng H*: Nafamostat mesylate versus regional citrate anticoagulation for continuous renal replacement therapy in patients at high risk of bleeding: a retrospective single-center study. Eur J Med Res 2024, 29(1):72.
4)Chen Y#, Zhao J#, Ye H#, Ceylan-Isik AF, Zhang B, Liu Q, Yang Y, Dong M, Luo B*, Ren J*: Beneficial impact of cardiac heavy metal scavenger metallothionein in sepsis-provoked cardiac anomalies dependent upon regulation of endoplasmic reticulum stress and ferroptosis but not autophagy. Life sciences 2024, 336:122291.
5)Zhao J#, Dai RS#, Chen YZ*, Zhuang YG*: Prognostic significance of lymphocyte subpopulations for ICU-acquired infections in patients with sepsis: a retrospective study. J Hosp Infect 2023, 140:40-45.
6)Chen Y#, Liu D#, Li X, Nie K, Yan S, Peng H, Zhuang Y*, Sun M*: Aggressive alternative splicing events discovered in cecum ligation and puncture induced lung injury. Biochemical and biophysical research communications 2023, 655:90-96.
7)Chen YZ, Zhou SQ, Chen YQ, Peng H*, Zhuang YG*: Plasma Adipokines in Patients Resuscitated from Cardiac Arrest: Difference of Visfatin between Survivors and Nonsurvivors. Dis Markers 2020, 2020:9608276.
8)Chen J#, Wang H#, Gao C, Liu D, Fan Y, Li W, Chen Y*, Pan S*: Tetramethylpyrazine alleviates LPS-induced inflammatory injury in HUVECs by inhibiting Rho/ROCK pathway. Biochemical and biophysical research communications 2019, 514(1):329-335.
9)Chen Y#, Peng H#, Zhou S, Zhuang Y*: ADAR1 is targeted by miR-143 to regulate IL-1beta-induced endothelial activation through the NFkappaB pathway. Int J Biochem Cell Biol 2017, 89:25-33.
10)Chen Y#, Jiang B#, Zhuang Y, Peng H, Chen W*: Differential effects of heat shock protein 90 and serine 1179 phosphorylation on endothelial nitric oxide synthase activity and on its cofactors. PloS one 2017, 12(6):e0179978.
11)Wang H#, Chen Y#, Li W, Li C, Zhang X, Peng H*, Gao C*: Ligustrazine effect on lipopolysaccharide-induced pulmonary damage in rats. Burns : journal of the International Society for Burn Injuries 2015, 41(6):1235-1241.
12)Chen YZ, Yan SY, Chen YQ, Zhuang YG, Wei Z, Zhou SQ, Peng H*: Noninvasive monitoring of intra-abdominal pressure by measuring abdominal wall tension. World J Emerg Med 2015, 6(2):137-141.
13)Zhuang Y#, Li W#, Wang H, Peng H, Chen Y, Zhang X, Chen Y*, Gao C*: Predicting the Outcomes of Subjects With Severe Community-Acquired Pneumonia Using Monocyte Human Leukocyte Antigen-DR. Respir Care 2015, 60(11):1635-1642.
14)Chen S#, Li W#, Zhang Z#, Min H, Li H, Wang H, Zhuang Y, Chen Y*, Gao C, Peng H*: Evaluating the Quality of Cardiopulmonary Resuscitation in the Emergency Department by Real-Time Video Recording System. PloS one 2015, 10(10):e0139825.
15)Chen YZ, Xu YF, Zheng JH*: Effect of carbon dioxide pneumoperitoneum on human renal cell carcinoma proliferation and metastasis in an orthotropic xenograft nude mouse model. Archives of medical science : AMS 2014, 10(5):1041-1046.
16)Zhang C#, Chen Y#, Wang M, Chen X, Li Y, Song E, Liu X, Kim S*, Peng H*: PPM1D silencing by RNA interference inhibits the proliferation of lung cancer cells. World J Surg Oncol 2014, 12:258.
17)陈远卓, 严姝瑛, 陈艳清, 庄育刚, 赵伟, 周书琴, 彭沪*: 通过测量腹壁张力无创监测腹内压的临床研究. 中华急诊医学杂志 2014, 23(4):421-425.
二、科研课题:
1)睿E(睿意)急诊医学研究专项基金,22222012008,粪菌移植应用于危重症患者抗生素相关性腹泻治疗的临床研究,单中心,2022/10-2024/09,3万,在研,主持。
2)中央高校基本科研业务费专项资金,22120180391,内皮细胞Caspase-11依赖的焦亡炎症通路在脓毒症急性肺损伤中的作用及机制,2018/09-2019/08,5万,已结题,主持。
3)国家自然科学基金青年项目,81501696,ADAR1调控Caveolin-1对肺微血管内皮细胞通透性的影响及机制研究,2016/01-2018/12,21.6万,已结题,主持。
4)国家自然科学基金面上项目,81971804,TNIP2通过负向调控TNF-α信号通路减轻心肺复苏脑损伤的作用及机制研究,2020/01-2023/12,66万,已结题,第一参与人。
5)国家自然科学基金面上项目,81870011,粘合蛋白β4 表达调节机理在急性肺损伤中的作用,2019/01-2022/12,68.4万,已结题,第三参与人。
6)上海市卫计委面上项目,201740240,经鼻高流量呼吸治疗(HFNC)在慢性呼吸功能不全患者中的应用研究,2018/01-2020/12,10万,已结题,第二参与人。
7)国家自然科学基金面上项目,81671938,ADAR1调控Caspase-11非经典炎症小体激活在脓毒症急性肺损伤中的作用及机制,2017/01-2020/12,69.6万,已结题,第二参与人。
8)国家自然科学基金面上项目,81270133,辛伐斯坦通过claudin-5蛋白调节内皮细胞屏障功能,2013/01-2016/12,70万,已结题,主要参与人。
9)上海市卫生局项目,2012J011A,从Rock/MLCK信号通路研究川芎嗪对内皮微粒的生成及内皮细胞通透性的作用机制,2013/01-2016/12,2万,已结题,主要参与人。
10)国家自然科学基金青年项目,81000024,内皮微粒介导的Rock/MLCK通路的激活对肺微血管内皮细胞通透性的影响,2011/01-2013/12,20万,已结题,主要参与人。
11)上海市科委项目,11QA1405100,内毒素激活Rho信号调节肺微血管内皮细胞通透性及内皮微粒在此过程中的作用机制,2011/04-2013/03,15万,已结题,主要参与人。
12)上海市卫生局项目,2009143,ALI/ARDS患者机械通气时最佳PEEP值的临床研究,2010/01-2013/01,4万,已结题,主要参与人。
三、急诊重症相关论著:
1)新机械通气手册,新世界图书出版公司,2020年,副主编
2)胰腺整合介入治疗学(中英文版),美高梅出版社,2019年,参编(获第五届中国政府出版奖)
3)重症监护(消化系统监护部分),郑州大学出版社,2013年,参编
四、授权发明专利:(针对动物实验过程中的问题发明的实验改良装置)
1)陈远卓,一种带磁力扣固定装置的小鼠手术台,2017年,中国,ZL201620955686.4
五、牵头注册并建立全国多中心脓毒症队列研究(CHiCTR2200067084)