在脑保护研究中，首次发现并报道高压氧、吸入麻醉药、针刺麻醉等可模拟缺血预处理效果，诱导显著神经保护作用，并实现部分临床转化。提出了中国麻醉学发展方向应为围术期医学，以第一完成人获得国家科技进步一等奖、陕西省科学技术一等奖3项等奖项。获973、国家科技重大专项基金、国家自然科学基金重点基金、杰出青年基金等23项基金，发表SCI论著279篇（附代表性论文）。
In brain protection research, we firstly found and reported that hyperbaric oxygenation, inhalational anesthetics and acupuncture could mimic the ischemic preconditioning to induce obvious neuroprotection. Some innovations have been translated into clinical application. I proposed at the first time that the development direction of anesthesiology is perioperative medicine. My team (I am the first winner) got the first grade award for national scientific and technological achievement. Our research also got 3 first-grade awards for Shaanxi Provincial achievement of science and technology. I have got 23 research grants including the national basic research program of China (973 project), the national outstanding young scholars foundation, the key project of the national natural science foundation of China, et al. I have published 279 peer-reviewed SCI papers (the representative papers are attached).
一、在研科研项目
1.国家自然科学基金委员会，重大项目，82293640，围术期老年脑功能稳态维持的精准麻醉策略，1500万元，2023.01-2027.12，主持（Perioperative precise anesthesia strategies for maintaining the homeostasis of brain function in the elderly，Research expenditure 15 million）
2.国家自然科学基金委员会，重点项目，82293643，麻醉影响老年脑的特征性脑电及生物标记物预警体系的研究，450万元，2023.01-2027.12，主持（Study on the impact of anesthesia on EEG characteristics of aged brains and the establishment of a perioperative warning system using biomarkers，Research expenditure 4.5 million）
3.国家自然科学基金重点项目，82130121，髓样分化因子2在针刺镇痛整合效应中的作用机制，2022.1-2026.12 ， 290万 ，在研，主持（Key project of National Natural Science Foundation of China，Mechanism of myeloid differentiation factor 2 in integrated analgesic effect of acupuncture，Research expenditure 2. 9 million）
4.科技创新2030-“脑科学与类脑研究”重大项目-子课题，情绪情感调控注意和记忆的神经环路机制，2021.01-2026.12，200万，在研，主持（Scientific and Technological Innovation 2030 - Major Project of "Brain Science and Brain-inspired Research" - Sub-project, Neural Circuit Mechanism of Emotional Regulation Attention and Memory, 2 million）
5.国家自然科学基金重点项目，81730032，MD2在POCD形成中的双重作用机制及转化研究，2018.01-2022.12，300万元，在研，主持（Key project of National Natural Science Foundation of China，Study on the dual mechanism and transformation of MD2 in POCD formation，Research expenditure 3 million）
二 、 近年发表的论文
1.Wan H#, He M#, Cheng C#, Yang K#, Wu H, Cong P, Huang X, Zhang Q, Shi Y, Hu J*, Tian L*, Xiong L*. Clec7a Worsens Long-Term Outcomes after Ischemic Stroke by Aggravating Microglia-Mediated Synapse Elimination. Adv Sci (Weinh). 2024 Aug; 1:e2403064. (IF=14.3)
2.Sun L#, Man Q#, Zhang H, Xia S, Lu L, Wang X*, Xiong L*, Jiang S*. Strong cross immune responses against sarbecoviruses but not merbecoviruses in SARS-CoV-2 BA.5/BF.7-infected individuals with or without inactivated COVID-19 vaccination. J Infect. 2024 Apr;88(4):106138. (IF=14.3)
3.Dai D, Zhao T, Li Z, Li W, Chen A, Tang Y, Gao XF*, Xiong L*. The plasticity of neuropeptide Y-Y1 receptor system on Tac2 neurons contributes to mechanical hyperknesis during chronic itch. Theranostics. 2024 Jan 1;14(1):363-378. (IF=12.4)
4.Guo Z#, Zhang J#, Yang B, Li L, Liu X, Xu Y, Wu Y, Guo P, Sun T, Dai S, Liang H, Wang J, Zou Y, Xiong L*, Huang J*. Organic High-Temperature Synaptic Phototransistors for Energy-Efficient Neuromorphic Computing. Adv Mater. 2024 Mar;36(13):e2310155. (IF=27.1)
5.Xu Y#, Liu D#, Dai S, Zhang J, Guo Z, Liu X, Xiong L*, Huang J*. Stretchable and neuromorphic transistors for pain perception and sensitization emulation. Mater Horiz. 2024 Feb 19;11(4):958-968. (IF=12.2)
6.Lu T#, Man Q#, Xia S#, Liu X, Yan Y, Yu X, Fu Y, Liu W, Lu L*, Jiang S*, Xiong L*. Multiple-cohort study of the elderly to determine the immunological characteristics and pathogenic mechanisms of severe community-acquired pneumonia caused by the low-virulence virus SARS-CoV-2 Omicron variant. Cell Discov. 2023 Dec 5;9(1):121. (IF=13.0)
7.Liu D*, Zhang J*, Shi Q, Sun T, Xu Y, Li L, Tian L, Xiong L*, Zhang J*, Huang J*. Humidity/Oxygen-Insensitive Organic Synaptic Transistors Based on Optical Radical Effect. Adv Mater. 2024 Jan;36(1):e2305370. (IF=27.1)
8.Dai S, Liu X, Liu Y, Xu Y, Zhang J, Wu Y, Cheng P, Xiong L*, Huang J*. Emerging Iontronic Neural Devices for Neuromorphic Sensory Computing. Adv Mater. 2023 Sep;35(39):e2300329. (IF=27.1)
9.Li Y#*, Sun H#, Huang Y#, Yin A#, Zhang L, Han J, Lyu Y, Xu X, Zhai Y, Sun H, Wang P, Zhao J, Sun S, Dong H, Zhu F, Wang Q, Augusto Rohde L, Xie X*, Sun X*, Xiong L*. Gut metagenomic characteristics of ADHD reveal low Bacteroides ovatus-associated host cognitive impairment. Gut Microbes. 2022 Jan-Dec;14(1):2125747. （IF=12.2）
10.Lu Z, Zheng H, Chen Z, Xu S, Chen S, Mi W, Wang T, Chai X, Guo Q, Zhou H, Yu Y, Zheng X, Zhang J, Ai Y, Yu B, Bao H, Zheng H, Huang W, Wu A, Deng X, Ma H, Ma W, Tao L, Yang X, Zhang J, Liu T, Ma HP, Liang W, Wang X, Zhang Y, Du W, Ma T, Xie Y, Xie Y, Li N, Yang Y, Zheng T, Zhang C, Zhao Y, Dong R, Zhang C, Zhang G, Liu K, Wu Y, Fan X, Tan W, Li N, Dong H*, Xiong L*. Effect of Etomidate vs Propofol for Total Intravenous Anesthesia on Major Postoperative Complications in Older Patients: A Randomized Clinical Trial.JAMA Surg. 2022;e223338. (IF:18.681)
11.Zongping Fang#, Di Wu#, Jiao Deng#, Qianzi Yang,Xijing Zhang,Jian Chen,Shiquan Wang,Sijun Hu,Wugang Hou,Siming Ning,Yi Ding,Zhongmin Fan,Zhenhua Jiang,Junjun Kang,Yingying Liu,Jinlin Miao,Xunming Ji*, Hailong Dong*, Lize Xiong*. An MD2-perturbing peptide has therapeutic effects in rodent and rhesus monkey models of stroke. Sci Transl Med. 2021 Jun; 13(597):eabb6716. doi: 10.1126/scitranslmed.abb6716.（IF：19.319）
12.Junyao Zhang#, Qianqian Shi, Ruizhi Wang, Xuan Zhang, Li Li, Jianhua Zhang, Li Tian*, Lize Xiong*, Jia Huang*. Spectrum-dependent photonic synapses based on 2D imine polymers for power-efficient neuromorphic computing. InfoMat. 2021 May 3(8). DOI:10.1002/inf2.12198.（IF：24.798）
13.Liu L #*, Li J #, Zuo L, Zhang J, Zhou M, Xu B, Hahn R, Leon M, His D, Ge J, Zhou X, Zhang J, Ge S, Xiong L*. Safety and Efficacy of Percutaneous Intra-myocardial Septal Radiofrequency Ablation for Hypertrophic Obstructive Cardiomyopathy. J Am Coll Cardiol. 2018 Oct 16;72(16):1898-1909. (IF=18.639)
14.Lei C #, Berra L #, Rezoagli E, Yu B, Dong H, Yu S, Hou L, Chen M, Chen W, Wang H, Zheng Q, Shen J, Jin Z, Chen T, Zhao R, Zhao, Christie E, Sabbisetti V, Nordio F, Bonventre J, Xiong L*, Zapol W*. Nitric Oxide Decreases Acute Kidney Injury and Stage 3 Chronic Kidney Disease after Cardiac Surgery. Am J Respir Crit Care Med. 2018 Nov 15;198(10):1279-1287. (IF=16.494)
15.Li Y#*, Yin A#, Sun X#, Zhang M#, Zhang J, Wang P, Xie R, Li W, Fan Z, Zhu Y, Wang H, Dong H, Wu S, Xiong L*.Deficiency of tumor suppressor NDRG2 leads to attention deficit and hyperactive behavior. J Clin Invest. 2017 Oct 23. pii: 94455. (IF=13.251)
16.Zhong H#, Tong L#, Gu N#, Gao F#, Lu Y, Xie R, Liu J, Li X, Bergeron R, Pomeranz L, Mackie K, Wang F, Luo C, Ren Y, Wu S, Xie Z, Xu L, Li J, Dong H*, Xiong L*, Zhang X*. Endocannabinoid signaling in hypothalamic circuits regulates arousal from general anesthesia in mice. J Clin Invest. 2017 Jun 1;127(6):2295-2309 (IF=13.251)
