承担课题:
2023.04~2026.03 LDHB介导的肿瘤细胞焦亡激活CAFs调控胰腺癌肿瘤微环境的机制研究（上海市“科技创新行动计划”自然科学基金，项目批准号：23ZR1452300，资助额度：20万）在研，主持
2020.01~2023.12 濒死细胞通过Caspases调控Hippo信号通路促进胰腺癌放化疗后再增殖的机制研究（国家自然科学基金面上项目，项目批准号：81972280，资助额度：55万）在研，主持
2016.01 ~ 2018.12 Merlin/FoxM1 信号轴在PanIN恶性转化中的作用及机制
（国家自然科学基金青年项目，项目批准号：81502043，资助额度：18万）已结题，主持
2019.07~2022.06 MSI1-Hippo信号轴调控胃癌干性特征的机制研究 （上海市自然科学基金，项目批准号：19ZR1441800，资助额度：20万）结题，主持
2019年入选上海市医苑新星青年医学人才培养计划，项目批准号：yyxx201901，10万，结题，主持
Grant:
Shanghai natural science fund, No. 23ZR1452300, Mechanism of tumor pyroptosis mediating by LDHB regulating tumor microenvironment via activating CAFs in pancreatic cancer, 2023.04~2026.03, 200000.
National Natural Science Foundation of China, No.81972280, machanism of Dying cells stimulate repopulation of pancreatic cancer cells via Caspases regulating Hippo pathway during Radiotherapy and chemotherapy, 2020.01~2023.12, 550000.
National Natural Science Foundation of China, No.81502043, The Critical Role and Mechanism of Merlin/FoxM1 during the Malignant Transformation from PanIN to Pancreatic Cancer, 2016.01 ~ 2018.12, 180000.
Shanghai natural science fund, No. 19ZR1441800, The mechanism of MSI1-Hippo signal axis regulating the Stem cell properties of gastric cancer, 2019.07~2022.06, 200000.
Shanghai “Rising Stars of Medical Talent” Youth Development Program, No.yyxx201901, 202001~202212. 100000.
发表论文（published paper）
Quan M, Chen J, Chen Z, Hai Y, Zhou Y, Chao Q, Chen C, Li H, Wang M, Gao Y. Cetuximab retreatment plus camrelizumab and liposomal irinotecan in patients with RAS wild-type metastatic colorectal cancer: Cohort B of the phase II CRACK study. Int J Cancer. 2023 May 10. doi: 10.1002/ijc.34531. Online ahead of print. PMID: 37163613
Li N, Chen Z, Huang M, Zhang D, Hu M, Jiao F, Quan M（Corresponding author/通讯作者）. Detection of ROS1 gene fusions using next-generation sequencing for patients with malignancy in China. Front Cell Dev Biol. 2022 Dec 15;10:1035033. doi: 10.3389/fcell.2022.1035033. eCollection 2022.
Quan M, Chen Z, Chen J, Hai Y, Gao Y. Preliminary experience of oral fruquintinib-capecitabine as a new maintenance treatment strategy for advanced colorectal cancer in the era of coronavirus disease 2019 (COVID-19): case report and literature review. J Gastrointest Oncol. 2022 Oct;13(5):2660-2666. doi: 10.21037/jgo-22-824.
Chong X, Chen J, Zheng N, Zhou Z, Hai Y, Chen S, Zhang Y, Yu Q, Yu S, Chen Z, Bao W, Quan M（Co-Corresponding author/共同通讯作者）, Chen ZS, Zhan Y, Gao Y. PIK3CA mutations-mediated downregulation of circLHFPL2 inhibits colorectal cancer progression via upregulating PTEN. Mol Cancer. 2022 May 26;21(1):118. doi: 10.1186/s12943-022-01531-x.PMID: 35619132.
Chen Z, Song H, Zeng X, Quan M（Co-Corresponding author/共同通讯作者）, Gao Y. Screening and discrimination of optimal prognostic genes for pancreatic cancer based on a prognostic prediction model. G3 (Bethesda). 2021 Oct 19;11(11):jkab296. doi: 10.1093/g3journal/jkab296.PMID: 34499727.
Chen Z, Chen J, Gao Y, Quan M（Corresponding author/通讯作者）. Heterogeneous clinical and pathological landscapes of HER2 positive colorectal cancer. Expert Rev Anticancer Ther. 2021 Jun 16. doi: 10.1080/14737140.2021.1944108. Online ahead of print.
Liu S, Huang M, Chen Z, Chen J, Chao Q, Yin X, Quan M（Corresponding author/通讯作者）. FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13. Exp Cell Res. 2020 Feb 6:111894. doi: 10.1016/j.yexcr.2020.111894. [Epub ahead of print]
Quan M, Chen Z, Jiao F, Xiao X, Xia Q, Chen J, Chao Q, Li Y, Gao Y, Yang H, Wang L, Cui J. Lysine demethylase 2 (KDM2B) regulates hippo pathway via MOB1 to promote pancreatic ductal adenocarcinoma (PDAC) progression. J Exp Clin Cancer Res. 2020 Jan 15;39(1):13. doi: 10.1186/s13046-019-1489-0.
Xie D, Yu S, Li L, Quan M（Co-Corresponding author/通讯作者）, Gao Y. The FOXM1/ATX signaling contributes to pancreatic cancer development. Am J Transl Res. 2020 Aug 15;12(8):4478-4487. eCollection 2020.
Chen J, Quan M(Co-First author/共同第一作者), Chen Z, Zeng T, Li Y, Zhou Y, Hai Y, Gao Y. Camrelizumab in advanced or metastatic solid tumour patients with DNA mismatch repair deficient or microsatellite instability high: an open-label prospective pivotal trial. J Cancer Res Clin Oncol. 2020 Oct;146(10):2651-2657. doi: 10.1007/s00432-020-03251-5. Epub 2020 Jul 4.
Cui J, Quan M(Co-First/Corresponding author/共同第一/通讯作者), Xie D, Gao Y, Guha S, Fallon MB, Chen J, Xie K. A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism. Oncogene. 2020 Jan;39(5):1140-1151. doi: 10.1038/s41388-019-1051-8. Epub 2019 Oct 22.
Cui J, Zhou Z, Yang H, Jiao F, Li N, Gao Y, Wang L, Chen J, Quan M(Corresponding author/通讯作者). MST1 Suppresses Pancreatic Cancer Progression via ROS-Induced Pyroptosis. Mol Cancer Res. 2019 Jun;17(6):1316-1325. doi: 10.1158/1541-7786.MCR-18-0910. Epub 2019 Feb 22.
Guo K, Cui J, Quan M(Co-First author/共同第一作者),Xie D, Jia Z, Wei D, Wang L, Gao Y, Ma Q, Xie K.A novel KLF4-MSI2 signaling pathway regulates growth and metastasis of pancreatic cancer.Clin Cancer Res. 2017 Feb 1;23(3):687-696.
Jiujie Cui,Tian Xia, DachengXie, Yong Gao, ZhiliangJia, Daoyan Wei, Liang Wang, Suyun Huang, Ming Quan（Co-Corresponding author/共同通讯作者）, KepingXie. HGF/Met and FoxM1 form a positive feedback loop and render pancreatic cancer cells proliferation to Met inhibition and aggressive phenotypes. Oncogene. 2016 Sep 8;35(36):4708-18 (IF:7.971)
Quan M ,Jiujie Cui, Tian Xia, ZhiliangJia, DachengXie, Daoyan Wei, SuyunHuang, Qian Huang, Shaojiang Zheng, KepingXie. Merlin/NF2 Suppresses Pancreatic Cancer Growth and Metastasis by Attenuating FOXM1-mediated Wnt/β-Catenin Signaling Pathway.Cancer Res. 2015 Nov 15;75(22):4778-89.
Quan M , Wang P, Cui J, Gao Y, Xie K. The roles of FOXM1 in pancreatic stem cells and carcinogenesis.Mol Cancer. 2013 Dec 10;12:159. doi: 10.1186/1476-4598-12-159
