1.消化道肿瘤发生与靶向精准治疗/ Gastrointestinal Tumor Generation and Targeted Precision Therapy2.胃肠肿瘤免疫微环境与免疫治疗/ Immune Microenvironment and Immunotherapy of Gastrointestinal Tumors
美高梅附属东方医院消化肿瘤专科主任/ Director of digestive tumor department, East Hospital Affiliated to Tongji University上海市浦东新区肿瘤专业委员会主任委员/ Chairman of the Cancer Professional Committee of Shanghai Pudong New District中国医药教育协会盆腔肿瘤专业委员会副主任委员/ Vice-Chairman of Pelvic Cancer Professional Committee of China Medical Education Association中华医学会肿瘤姑息治疗专业委员会委员/ Professional Committee on Palliative Treatment of Cancer, Chinese Medical AssociationCSCO胰腺癌专家委员会委员/ Committee Member of CSCO Pancreatic Cancer Expert CommitteeCSCO肝癌专家委员会委员/ Committee Member of CSCO Hepatocellular Carcinoma Expert Committee
Funds:1.国家自然科学基金81272917FoxM1调控TGF-β1/Smad信号通路促进乳腺癌EMT机制研究。课题负责人60万2013.01-2016.12/ National Natural Science Foundation of China(81272917), 2013.01-2016.12
2.国家自然科学基金81172022KLF4调控uPAR在肝细胞癌发生上皮－间质转化中的作用和机制研究 课题负责人55万2012.01-2015.12/ National Natural Science Foundation of China(81172022), 2012.01-2015.12
3.上海市医学重点专科肿瘤专科（ZK2012A26）, 课题负责人 120万 2013.01-2016.12/ Oncology Speciality of Shanghai Key Medical Speciality（ZK2012A26）, 2013.01-2016.12
4.上海市浦东新区领先人才，浦东新区PWR12013-02，负责人40万2013.11-2017.10 / Leading Talents in Shanghai Pudong New Area(PWR12013-02), 2013.11-2017.10
5.浦东新区卫生系统重点学科群，浦东新区卫计委PWZxq2014-0，负责人150万2014.04-2017.03/ Key Subjects Group of Health System in Pudong New Area(PWZxq2014-0), 2014.04-2017.03
6.国家自然科学基金81472576KLF4通过HNF-6信号通路影响肝癌细胞分化的机制研究。课题负责人72万2015.01-2018.12/ National Natural Science Foundation of China(81472576), 2015.01-2018.12
7.国家自然科学基金81772567 RNA编辑酶ADAR1调控PARP1在胃癌细胞化疗耐药中的作用及机制研究。课题负责人65万2017.01-2020.12/ National Natural Science Foundation of China(81772567), 2017.01-2020.12
Bibliography:1.Yu S, Gautam N, Quan M, Gao Y. RSRC1 suppresses gastric cancer cell proliferation and migration by regulating PTEN expression. Mol Med Rep. 2019 Aug;20(2):1747-1753. doi: 10.3892/mmr.2019.10409. Epub 2019 Jun 21. PubMed PMID: 31257492.
2.Li Y, Yu S, Wang X, Ye X, He B, Quan M, Gao Y. SRPK1 facilitates tumor cell growth via modulating the small nucleolar RNA expression in gastric cancer. J Cell Physiol. 2019 Aug;234(8):13582-13591. doi: 10.1002/jcp.28036. Epub 2019 Jan 11. PubMed PMID: 30633341.
3.Yu S, Wang X, Dou N, Zhou J, Gao Y, Li Y. B-cell lymphoma-2-associated transcription factor 1 is overexpressed and contributes to sorafenib resistance in hepatocellular carcinoma. Hepatol Res. 2019 Jun 24;. doi: 10.1111/hepr.13395. [Epub ahead of print] PubMed PMID: 31237058.
4.Li L, Yu S, Wu Q, Dou N, Li Y, Gao Y. KLF4-Mediated CDH3 Upregulation Suppresses Human Hepatoma Cell Growth and Migration via GSK-3β Signaling. Int J Biol Sci.2019;15(5):953-961. doi: 10.7150/ijbs.30857. eCollection 2019. PubMed PMID: 31182916; PubMed Central PMCID: PMC6535787.
5.Chen J, Li L, Zhou Z, Yu S, Li Y, Gao Y. FAPP2 promotes tumor cell growth in human colon cancer through activation of Wnt signaling. Exp Cell Res. 2019 Jan 1;374(1):12-18. doi:10.1016/j.yexcr.2018.11.002. Epub 2018 Nov 5. PubMed PMID: 30408464.
6.Dou N, Yang D, Yu S, Wu B, Gao Y, Li Y. SNRPA enhances tumour cell growth in gastric cancer through modulating NGF expression. Cell Prolif. 2018 Oct;51(5):e12484. doi: 10.1111/cpr.12484. Epub 2018 Jul 24. PubMed PMID: 30039889.
7.Yu S, Li L, Wu Q, Dou N, Li Y, Gao Y. PPP2R2D, a regulatory subunit of protein phosphatase 2A, promotes gastric cancer growth and metastasis via mechanistic target of rapamycin activation. Int J Oncol. 2018 Jun;52(6):2011-2020. doi: 10.3892/ijo.2018.4329. Epub 2018 Mar 20. PubMed PMID: 29568966.
8.Zhang Y, Ye X, Chen L, Wu Q, Gao Y, Li Y. PARI functions as a new transcriptional target of FOXM1 involved in gastric cancer development. Int J Biol Sci. 2018;14(5):531-541. doi: 10.7150/ijbs.23945. eCollection 2018. PubMed PMID: 29805304; PubMed Central PMCID: PMC5968845.
9.Wu Q, Yu S, Chen J, Li Y, Gao Y. Downregulation of STRAP promotes tumor growth and metastasis in hepatocellular carcinoma via reducing PTEN level. IUBMB Life. 2018 Feb;70(2):120-128. doi: 10.1002/iub.1707. Epub 2017 Dec 28. PubMed PMID: 29283497.
10.Wang Y, Jiang J, Li Q, Ma H, Xu Z, Gao Y. KAP1 is overexpressed in hepatocellular carcinoma and its clinical significance. Int J Clin Oncol. 2016 Oct;21(5):927-933. doi: 10.1007/s10147-016-0979-8. Epub 2016 Apr 19. PubMed PMID: 27095111.
11.Wang X, He B, Gao Y, Li Y. FOXR2 contributes to cell proliferation and malignancy in human hepatocellular carcinoma. Tumour Biol. 2016 Aug;37(8):10459-67. doi: 10.1007/s13277-016-4923-3. Epub 2016 Feb 5. PubMed PMID: 26846213.
12.Ye X, Zhang Y, Wang X, Li Y, Gao Y. Tumor-suppressive functions of long-chain acyl-CoA synthetase 4 in gastric cancer. IUBMB Life. 2016 Apr;68(4):320-7. doi: 10.1002/iub.1486. Epub 2016 Mar 7. PubMed PMID: 26949059.
13.Li Y, Wang X, He B, Cai H, Gao Y. Downregulation and tumor-suppressive role of XPO5 in hepatocellular carcinoma. Mol Cell Biochem. 2016 Apr;415(1-2):197-205. doi: 10.1007/s11010-016-2692-3. Epub 2016 Mar 21. PubMed PMID: 27000860.
14.Li Q, Li Y, Wang Y, Cui Z, Gong L, Qu Z, Zhong Y, Zhou J, Zhou Y, Gao Y, Li Y. Quantitative proteomic study of human prostate cancer cells with different metastatic potentials. Int J Oncol. 2016 Apr;48(4):1437-46. doi: 10.3892/ijo.2016.3378. Epub 2016 Feb 4. PubMed PMID: 26846621.
15.Ye X, Zhang Y, He B, Meng Y, Li Y, Gao Y. Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration. Int J Clin Exp Pathol. 2015;8(12):15836-44. eCollection 2015. PubMed PMID: 26884854; PubMed Central PMCID: PMC4730067.
16.Li Y, Lin Y, Li Q, Gao Y. SRrp35 suppresses cell proliferation and malignancy in hepatocellular carcinoma. Hepatol Res. 2015 Dec;45(12):1241-7. doi: 10.1111/hepr.12493. Epub 2015 Mar 17. PubMed PMID: 25594558.
17.Chen Y, Cha Z, Fang W, Qian B, Yu W, Li W, Yu G, Gao Y. The prognostic potential and oncogenic effects of PRR11 expression in hilar cholangiocarcinoma. Oncotarget. 2015 Aug 21;6(24):20419-33. doi: 10.18632/oncotarget.3983. PubMed PMID: 25971332; PubMed Central PMCID: PMC4653015.
18.Feng C, Li X, Dong C, Zhang X, Zhang X, Gao Y. RGD-modified liposomes enhance efficiency of aclacinomycin A delivery: evaluation of their effect in lung cancer. Drug Des Devel Ther. 2015;9:4613-20. doi: 10.2147/DDDT.S85993. eCollection 2015. PubMed PMID: 26316700; PubMed Central PMCID: PMC4541546.
19.Cai H, Chen J, He B, Li Q, Li Y, Gao Y. A FOXM1 related long non-coding RNA contributes to gastric cancer cell migration. Mol Cell Biochem. 2015 Aug;406(1-2):31-41. doi: 10.1007/s11010-015-2421-3. Epub 2015 Apr 24. PubMed PMID: 25907137.
20.Cai H, Ye X, He B, Li Q, Li Y, Gao Y. LncRNA-AP001631.9 promotes cell migration in gastric cancer. Int J Clin Exp Pathol. 2015;8(6):6235-44. eCollection 2015. PubMed PMID: 26261500; PubMed Central PMCID: PMC4525834.
21.Chen J, Jiang H, Wu Y, Li Y, Gao Y. A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation. Drug Des Devel Ther. 2015;9:2265-75. doi: 10.2147/DDDT.S81722. eCollection 2015. PubMed PMID: 25945038; PubMed Central PMCID: PMC4408971.
22.Wang Y, Wang Q, Zhang N, Ma H, Gu Y, Tang H, Xu Z, Gao Y. Identification of microRNAs as novel biomarkers for detecting esophageal squamous cell carcinoma in Asians: a meta-analysis. Tumour Biol. 2014 Nov;35(11):11595-604. doi: 10.1007/s13277-014-2350-x. Epub 2014 Aug 19. PubMed PMID: 25135426.
23.Shi M, Cui J, Du J, Wei D, Jia Z, Zhang J, Zhu Z, Gao Y, Xie K. A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer. Clin Cancer Res. 2014 Aug 15;20(16):4370-80. doi: 10.1158/1078-0432.CCR-14-0186. Epub 2014 Jun 19. PubMed PMID: 24947925; PubMed Central PMCID: PMC4134726.
24.Li Q, Tian Y, Li D, Sun J, Shi D, Fang L, Gao Y, Liu H. The effect of lipocisplatin on cisplatin efficacy and nephrotoxicity in malignant breast cancer treatment. Biomaterials. 2014 Aug;35(24):6462-72. doi: 10.1016/j.biomaterials.2014.04.023. Epub 2014 May 3. PubMed PMID: 24797881.
25.Li Q, Wang H, Yu L, Zhou J, Chen J, Zhang X, Chen L, Gao Y, Li Q. ChIP-seq predicted estrogen receptor biding sites in human breast cancer cell line MCF7. Tumour Biol. 2014 May;35(5):4779-84. doi: 10.1007/s13277-014-1627-4. Epub 2014 Jan 28. PubMed PMID: 24470138.
26.Yang L, Yang S, Liu J, Wang X, Ji J, Cao Y, Lu K, Wang J, Gao Y. Expression of GRP78 predicts taxane-based therapeutic resistance and recurrence of human gastric cancer. Exp Mol Pathol. 2014 Apr;96(2):235-41. doi: 10.1016/j.yexmp.2014.02.011. Epub 2014 Mar 3. PubMed PMID: 24602846.
27.Huang C, Xie D, Cui J, Li Q, Gao Y, Xie K. FOXM1c promotes pancreatic cancer epithelial-to-mesenchymal transition and metastasis via upregulation of expression of the urokinase plasminogen activator system. Clin Cancer Res. 2014 Mar 15;20(6):1477-88. doi: 10.1158/1078-0432.CCR-13-2311. Epub 2014 Jan 22. PubMed PMID: 24452790; PubMed Central PMCID: PMC3959252.
28.Luo JH, Zhou J, Gao Y. Correlation between periostin and SNCG and esophageal cancer invasion, infiltration and apoptosis. Asian Pac J Trop Med. 2013 Jul;6(7):516-9. doi: 10.1016/S1995-7645(13)60088-7. PubMed PMID: 23768821.
29.Jiang H, Lin Y, Yang CQ, Li Q, Luo J, Zhou Y, Xue J, Wei W, Gao Y. Quantitative assessment of the association between XRCC6 C1310G polymorphism and cancer risk. Tumour Biol. 2013 Apr;34(2):779-85. doi: 10.1007/s13277-012-0607-9. Epub 2012 Dec 28. PubMed PMID: 23271361.
30.Li Q, Gao Y, Xu ZG, Jiang H, Yu YY, Zhu ZG. Effect of antisense oligodeoxynucleotide targeted against NF-κB/P65 on cell proliferation and tumorigenesis of gastric cancer. Clin Exp Med. 2013 Feb;13(1):11-9. doi: 10.1007/s10238-011-0174-1. Epub 2012 Jan 11. PubMed PMID: 22234797.
31.Li Q, Gao Y, Jia Z, Mishra L, Guo K, Li Z, Le X, Wei D, Huang S, Xie K. Dysregulated Krüppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma. Gastroenterology. 2012 Sep;143(3):799-810.e2. doi: 10.1053/j.gastro.2012.05.043. Epub 2012 Jun 4. PubMed PMID: 22677193; PubMed Central PMCID: PMC3653768.
32.Jiang H, Zhang X, Luo J, Dong C, Xue J, Wei W, Chen J, Zhou J, Gao Y, Yang C. Knockdown of hMex-3A by small RNA interference suppresses cell proliferation and migration in human gastric cancer cells. Mol Med Rep. 2012 Sep;6(3):575-80. doi: 10.3892/mmr.2012.943. Epub 2012 Jun 11. PubMed PMID: 22692246.
33.Gao Y, Jia Z, Kong X, Li Q, Chang DZ, Wei D, Le X, Suyun H, Huang S, Wang L, Xie K. Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis. Cancer Res. 2011 Aug 1;71(15):5182-93. doi: 10.1158/0008-5472.CAN-10-2016. Epub 2011 Jun 14. PubMed PMID: 21673052; PubMed Central PMCID: PMC3245664.
