科研项目：
1.
国家自然科学基金面上项目，批准号：81772715，MEG3基因敲除对小鼠前列腺正常功能的影响和与前列腺癌转移的机制研究，2018/01－2021/12，53万元，负责人：刘瑞芳（已批准）
2.
国家自然科学基金青年基金项目，批准号81302209，miR-199a-3p靶向CD44+干/祖细胞对前列腺癌发生和转移的抑制作用研究，2014/01－2016/12，23万元，负责人：刘瑞芳（已结题）
3.
上海市自然科学基金青年项目，批准号：13ZR1459900，miR-199a-3p对CD44+前列腺癌干/祖细胞的调控作用及其对前列腺癌治疗效果的初步研究，2013/10－2016/09，10万元，负责人：刘瑞芳 （已结题）
4.
美高梅青年优秀人才培养行动计划，2012KJ041，Hsa-miR-199a-3p对前列腺癌干/祖细胞CD44阳性细胞的作用，2013/01－2014/12，2.5万元，负责人：刘瑞芳（已结题）
发表文章：
1.
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Xu*, R.F. Liu*, D.X. Zhang, B.G. Liu, K. Racaj, H.P. Chao, X.N. Zhang,
T.C. Davis, J.S. Kirk, M. Chen, D.G. Tang. LncRNA MEG3 functions as a
tumor-suppressor in prostate cancer. (Eur. Urol, to be submitted) (*Co-first
authors)
2.
C.
Liu*, R.F. Liu*, Q. Deng, B.G. Liu, H.P. Chao, K. Rycaj, Y. Takata, K.
Lin, Y. Lu, Y. Zhong, J. Krolewski, J.J. Shen, D.G. Tang. MicroRNA-141
suppresses prostate cancer stem cells and metastasis by targeting a cohort of
pro-metastasis genes including CD44, Pho GTPases, and EZH2. Nat. Commun. 2017
Jan 23;8:14270. (*Co-first authors)
3.
R.F.
Liu,
C. Liu, D.X. Zhang, B.G. Liu, X. Chen, K. Rycaj, C. Jeter, T.C. Davis, Y.D. Li,
J.C. Wang, D.G. Tang. MicroRNA miR-199a-3p exhibits tumor-suppressive functions
in prostate cancer via targeting CD44, c-Myc, cyclin D1 and EGFR. Oncotarget.
2016;7:56628-42.
4.
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Chen, Q.H. Li, X. Liu, C. Liu, R.F. Liu, K. Rycaj, D.X. Zhang, B.G. Liu,
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a population of stem-like human prostate cancer cells that can generate and
propagate castration-resistant prostate cancer. Clin Cancer Res.
2016;22:4505-16.
5.
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Jin, T. Zhang, C. Liu, M. A. Badeaux, B. Liu, R. Liu, C. Jeter, X. Chen,
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6.
R.F.
Liu,
X. Xu, J. Huang, Q.L. Fei, F. Chen, Y.D. Li, Z.G. Han, Down-regulation of
miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells
via targeting Pyk2. Cancer Lett. 2013;329:164-73.
7.
Y.
Li, B. Zhou, J. Dai, R. Liu, Z.G. Han, Aberrant upregulation of LRRC1
contributes to human hepatocellular carcinoma. Mol Biol Rep. 2013;40:4543-51.
8.
J.
Huang, Q. Deng, Q. Wang, K.Y. Li, J.H. Dai, N. Li, Z.D. Zhu, B. Zhou, X.Y. Liu,
R.F. Liu, Q.L. Fei, H. Chen, B. Cai, B. Zhou, H.S. Xiao, L.X. Qin, Z.G.
Han, Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma.
Nat Genet. 2012;44:1117-21.
9.
X.
Xu, R.F. Liu, X. Zhang, L.Y. Huang, F. Chen, Q.L. Fei, Z.G. Han, DLK1 as
a potential target against cancer stem/progenitor cells of hepatocellular
carcinoma. Mol Cancer Ther. 2012;11:629-38.
X. Xu*, R.F. Liu*, B.B. Wan, W.M. Xing,
J. Huang, Z.G. Han, Expression of a novel gene FAM43B repressing cell
proliferation is regulated by DNA methylation in hepatocellular carcinoma cell
lines. Mol Cell Biochem. 2011;354:11-20. (*Co-first authors)
