作为项目负责人承担国家自然科学基金2项、浦东新区卫计委卫生科研青年项目及美高梅优秀青年人才培养行动计划等多项科研课题。目前已参与多项生物纳米及肿瘤免疫相关领域的研究工作；已在纳米生物医学相关领域SCI及核心期刊杂志发表文献数篇。
As the project leader, she undertook a number of scientific research projects, such as two National Natural Science Foundation projects, the Youth Project of Health Planning Committee of Pudong New Area, and the Action Plan for Training Outstanding Young Talents of Tongji University. Until now, she has participated in numerous research work in the field of bio-nano and tumor immunity. She has published several articles in SCI and core journals in the field of nano-biomedicine.
【已承担主要科研项目】
【Major scientific research projects undertaken】
(1) 国家自然科学基金委员会, 地区科学基金项目, 82160478, 构建装载双硫仑和卟啉MOF的CIK全细胞型肿瘤疫苗用于HER2阳性型乳腺癌诊疗的实验研究, 2022-01-01 至 2025-12-31, 35万元, 在研, 主持
(2) 国家自然科学基金委员会, 青年科学基金项目, 81703075, 光热型金纳米星标记DC-CIK免疫细胞对HER2过表达乳腺癌的作用及机制研究, 2018-01-01 至 2020-12-31, 20万元, 结题, 主持
(3) 浦东新区卫计委, 卫生科研青年项目, PW2017B-5, 阿帕替尼治疗晚期三阴性乳腺癌有效性和安全性的前瞻性随机对照临床研究, 2017-11 至 2020-10, 4万元, 结题, 主持
(4) 美高梅, 优秀青年人才培养行动计划, 2016KJ064, 金纳米材料标记的免疫细胞在胃癌免疫治疗和免疫预防中潜在作用及机制, 2017-01 至 2018-12, 2.5万元, 结题, 主持
【已发表代表性论文】
【Representative papers published】
(1) Shujing Liang#,Jingxian Yang#,Yun Lin,Tong Li,Wenrong Zhao,Jun Zhao*,Chunyan Dong*. Immune Myocarditis Overlapping With Myasthenia Gravis Due to Anti-PD-1 Treatment for a Chordoma Patient: A Case Report and Literature Review.Frontiers in Immunology. 2021: 12:682262.(IF: 7.563)(第一作者)
(2) Shujing Liang*,Menglin Sun, Yonglin Lu, Shuo Shi, Yiting Yang, Yun Lin, Chan Feng, Jie Liu, Chunyan Dong*. Cytokine-induced killer cells-assisted tumor-targeting delivery of Her-2 monoclonal antibody-conjugated gold nanostars with NIR photosensitizer for enhanced therapy of cancer. Journal of Materials Chemistry B, 2020, 8, 8368-8382.(IF: 6.331) (第一作者)
(3) Shujing Liang, Chao Li, Chunlei Zhang, Yunsheng Chen, Liang Xu, Chenchen Bao, Xiaoyong Wang, Gang liu, Fengchun zhang*, Daxiang Cui*. CD44v6 Monoclonal Antibody-Conjugated Gold Nanostars for Targeted Photoacoustic Imaging and Plasmonic Photothermal Therapy of Gastric Cancer Stem-like Cells.Theranostic,2015, 5(9): 970-984.（IF:11.556）(第一作者)
(4) Yonglin Lu#, Yabin Ma#, Chan Feng, Donglei Zhu, Jie Liu, Lv Chen,Shujing Liang*, Chunyan Dong*. Co-delivery of Cyclopamine and Doxorubicin Mediated by Bovine Serum Albumin Nanoparticles Reverses Doxorubicin Resistance in Breast Cancer by Down-regulating P-glycoprotein Expression. Journal of cancer, 2019, 10(10):2357-2368.（IF: 4.207）(共同通讯作者)
(5) Chao Li, Shujing Liang, Chunlei Zhang, Yanlei Liu, Meng Yang, Jingpu Zhang, Xiao Zhi, Fei Pan, Daxiang Cui*. Allogenic dendritic cell and tumor cell fused vaccine for targeted imaging and enhanced immunotherapeutic efficacy of gastric cancer.Biomaterial, 2015, 54, 177-187.（IF:12.479）(第二作者)
【科研成果】
【Achievements in scientific research】
梁淑静（6/10）；基于纳米材料抗肿瘤药物的设计合成与活性研究，上海医学会，上海医学科技奖，青年科技奖，2019（董春燕、石硕、任天斌、林昀、赵文荣、梁淑静、王坤、陈津津、李慧、强素凤）。
