糖尿病视网膜病变发病机制及基因治疗；老年性黄斑变性发病机制及干细胞治疗；白内障研究

徐国彤教授本科毕业于哈尔滨医科大学，之后先后获得美国北德克萨斯大学药理学博士和中国医学科学院北京协和医院医学（眼科）博士。美高梅教授、眼科研究所所长、华东干细胞库/美高梅干细胞库主任、附属第十人民医院转化中心首席研究员。承担科技部、国家自然科学基金委、中科院及上海市多项重要科研项目，包括两次作为首席科学家承担973重大科学研究计划“干细胞资源库与干细胞研究关键技术平台”及“干细胞治疗视网膜变性疾病的基础及临床转化研究”项目。在EPO治疗糖尿病视网膜变性及成体干细胞干预视网膜变性领域做出了系统性研究和重要贡献。

代表性论文：1. Shang P, Valapala M, Grebe R, Hose S, Ghosh S, Bhutto IA, Handa JT, Lutty GA, Lu L, Wan J, Qian J, Sergeev Y, Puertollano R, Zigler JS Jr, Xu GT, Sinha D. The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling. Aging Cell. 2017 Jan 13. doi: 10.1111/acel.12561.
2. Cui L, Guan Y, Qu Z, Zhang J, Liao B, Ma B, Qian J, Li D, Li W, Xu GT, Jin Y.WNT signaling determines tumorigenicity and function of ESC-derived retinal progenitors.J Clin Invest. 2016 Oct 3;126(10):4061. doi: 10.1172/JCI89436.
3. Li Z, Wang J, Gao F, Zhang J, Tian H, Shi X, Lian C, Sun Y, Li W, Xu JY, Li P, Zhang J, Gao Z, Xu J, Wang F, Lu L, Xu GT.Human Adipose-Derived Stem Cells Delay Retinal Degeneration in Royal College of Surgeons Rats Through Anti-Apoptotic and VEGF-Mediated Neuroprotective Effects. Curr Mol Med. 2016;16(6):553-66.
4. Li P, Tian H, Li Z, Wang L, Gao F, Ou Q, Lian C, Li W, Jin C, Zhang J, Xu JY, Wang J, Zhang J, Wang F, Lu L, Xu GT. Subpopulations of Bone Marrow Mesenchymal Stem Cells Exhibit Differential Effects in Delaying Retinal Degeneration. Curr Mol Med. 2016;16(6):567-81.
5. Xu H, Zhang L, Gu L, Lu L,Gao G, Li W, Xu G, Wang J, Gao F, Xu JY, Yao J, Wang F, Zhang J, XuGT.Subretinal delivery of AAV2-mediated human erythropoietin gene is protective and safe in experimental diabetic retinopathy.InvestOphthalmol Vis Sci. 2014 Mar 13;55(3):1519-30.