获得课题资助:国家自然科学基金面上项目,81871178,DNMT3A在子痫前期发生中的深入研究:基因body区甲基化异常的作用和机制,2019/01-2022/12,57万,在研,主持;
美高梅能力提升项目,DNMT3A在子痫前期胎盘基因组DNA甲基化异常调控中的作用机制,2017/9-2018/8,10万,结题,主持;
国家自然科学基金青年项目,81401217,DNA甲基转移酶3A在子痫前期发生中的作用及机制研究,2015/01-2017/12,23万,结题,主持;
美高梅青年优秀人才培养行动计划,DNMT3A参与滋养层细胞形成的机理研究,2014/01-2015/12,10万元,结题,主持
发表论文:
1.Jia Yuanhui,Xie Han,Zhang Jiqin,Hao Ying*,Induction of TGF-β receptor I expression in a DNA methylation independent manner mediated by DNMT3A down-regulation is involved in early-onset severe preeclampsia,FASEB JOURNAL,2020 Aug 14. doi: 10.1096/fj.202000253RR. (IF=5.0);
2.Jia Yuanhui(#),Li Ting(#),Huang Xiaojie,Xu Xianghong,Zhou Xinyao,Jia Linyan,Zhu Jingping,Xie Dandan,Wang Kai,Zhou Qian,Jin Liping,Zhang Jiqin(*),Duan Tao(*),Dysregulated DNA Methyltransferase 3A Upregulates IGFBP5 to Suppress Trophoblast Cell Migration and Invasion in Preeclampsia,Hypertension,2017.02,69(2):356~366 (IF=7.7);
3.Jia Yuanhui(#),Li Pishun(#),Fang Lan(#),Zhu Haijun,Xu Liangliang,Cheng Hao,Zhang Junying,Li Fei,Feng Yan,Li Yan,Li Jialun,Wang Ruiping,Du James X,Li Jiwen,Chen Taiping,Ji Hongbin,Chen Jackie,Yu Wenqiang,Wu Qihan,Wong Jiemin(*),Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer,Cell Discovery,2016.4.12,2(16007)(IF=6.2);
4.Qiu Jihui(#),Shi Guang(#),Jia Yuanhui(#),Li Jing,Wu Meng,Li Jiwen,Dong Shuo,Wong Jiemin(*),The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation,Cell Research,2010.8.01,20(8):908~918 (Co-first author) (IF=20.5);
5.Zhu Jingping,Wang Kai,Li Ting,Chen Jiayu,Xie Dandan,Chang Xinwen,Yao Julei,Wu Jinting,Zhou Qian,Jia Yuanhui*,Duan Tao*,Hypoxia-induced TET1 facilitates trophoblast cell migration and invasion through HIF1α signaling pathway,Sci Rep,2017 Aug 14;7(1):8077,doi: 10.1038/s41598-017-07560-7. (Corresponding author) (IF=4.0);
6.Xie Dandan,Zhu Jingping,Liu Qianqian,Li Jun,Song Mengjiu,Wang Kai,Zhou Qian,Jia Yuanhui*,Li Ting *,Dysregulation of HDAC9 represses trophoblast cell migration and invasion through TIMP3 activation in preeclampsia,American Journal of Hypertension,2019 Apr 22;32(5):515-523. (Corresponding author) (IF=2.6)