肾癌的缺氧微环境研究、肿瘤干细胞的基础临床研究；前列腺癌耐药机制、肿瘤微环境、肿瘤干细胞的研究 Research on hypoxic microenvironment of kidney cancer, basic clinical research on tumor stem cells; research on the drug resistance mechanism of prostate cancer, tumor microenvironment, and tumor stem cells
本人长期从事肾癌和前列腺癌的基础和临床研究，期间作为博士后在美国罗切斯特大学George Whipple实验室博从事肿瘤干细胞的研究。目前主要专注与肾癌和前列腺癌肿瘤干细胞的研究。目前主持院内国自然孵育项目一项 5万元，主持美高梅优秀青年培养项目一项 5万元，主持国家自然基金青年项目：21万。参与肾癌及前列腺癌多项研究。在泌尿肿瘤的研究方面以第一作者或通讯作者发表文章20余篇，其中SCI发表在cell death and differentiation, oncegene, cancer letters等杂志15篇，单篇最高影响因子12分。
I have been engaged in the basic and clinical research of kidney cancer and prostate cancer for a long time. During the period, I worked as a postdoctoral fellow in the George Whipple laboratory of the University of Rochester in the United States and engaged in cancer stem cell research. At present, I mainly focuses on the research of tumor stem cells of kidney cancer and prostate cancer. Participated in a number of studies on kidney cancer and prostate cancer. In the research of urinary tumors, more than 20 articles have been published as the first author or corresponding author. Among them, SCI has published 15 articles in cell death and differentiation, oncegene, cancer letters and other journals. The highest impact factor of a single article is 12 points. 代表作列表：
[1] GUO C, YEH S, NIU Y, et al. Targeting androgen receptor versus targeting androgens to suppress castration resistant prostate cancer [J]. Cancer Lett, 2017, 397(133-43.(IF=5.992)
[2] Shi H, Xie J, Wang K, Li W, Yin L, Wang G, Wu Z, Ni J, Mao W, Guo C, Peng B. LINC01451 drives epithelial-mesenchymal transition and progression in bladder cancer cells via LIN28/TGF-β/Smad pathway. Cellular Signalling. 2021 May 1;81:109932.
[3] Guo C, Li X, Xie J, Liu D, Geng J, Ye L, Yan Y, Yao X, Luo M. Long Noncoding RNA SNHG1 Activates Autophagy and Promotes Cell Invasion in Bladder Cancer. Frontiers in oncology. 2021 May 13;11:1722.
[4] Guo, C., Zhu, K., Sun, W. et al.: The effect of Pokemon on bladder cancer epithelial-mesenchymal transition. Biochem Biophys Res Commun, 443: 1226, 2014.
[5] Guo, C., Yang, B., Gu, W. et al.: Intravesical resiniferatoxin for the treatment of storage lower urinary tract symptoms in patients with either interstitial cystitis or detrusor overactivity: a meta-analysis. PLoS One, 8: e82591, 2013.
[6] Guo, C. C., Zhang, X. L., Yang, B. et al.: Decreased expression of Dkk1 and Dkk3 in human clear cell renal cell carcinoma. Mol Med Rep, 9: 2367, 2014.
[7] Wei Zhai, Yin Sun, Changcheng Guo, Guanghui Hu, Mingchao Wang, Jiayi Zheng, WanYing Lin, Qingbo Huang, and Junhua Zheng. LncRNA-SARCC suppresses renal cell carcinoma (RCC) progression via altering the androgen receptor(AR)/ miRNA-143-3p signals. cell.death.differ 2017.
[8] Guo C, Xiong D, Yao X, et al. Decreased SATB2 expression is associated with metastasis and poor prognosis in human clear cell renal cell carcinoma[J]. International journal of clinical and experimental pathology, 2015, 8(4): 3710.
[9] Guo C, Gu W, Liu M, Peng B, Yao X, Yang B, Zheng J. Efficacy and safety of testosterone replacement therapy in men with hypogonadism: A meta-analysis study of placebo-controlled trials. Experimental and therapeutic medicine. 2016 Mar 1;11(3):853-63.
[10] Guo C, Yan Y, Yang B, Liu M, Zhang H, Peng B, Yao X, Zheng J. Body mass index, prostate volume and health condition are associated with the risk of prostate cancer detectionin a biopsy population. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE. 2016 Jan 1;9(2):4396-403.
[11]changcheng guo, Dabo Xiong, Bin Yang, Haiming Zhang, Wenyu Gu, Min Liu, Xudong Yao, Junhua Zheng, Bo Peng. Expression and clinical significance of Pokemon in transitional cell carcinoma of the bladder. Oncology Letters.
[12]Che J, Wu P, Wang G, Yao X, Zheng J, Guo C#. Expression and clinical value of SALL4 in renal cell carcinomas. Molecular Medicine Reports. 2020 May 22.
[13]Che J, Yao X, Wang C, Zheng J, Guo C#. Hypoxia promoted renal cell carcinoma cell migration through regulating lncRNA-ENST00000574654. 1. American Journal of Translational Research. 2020;12(7):3884.
