胸外科主治医师，硕士研究生导师，长期从事胸心外科的临床工作和基础研究，IASLC会员，上海市抗癌协会会员。2016年-2018年先后于美国乔治亚美高梅任Research Assistant和美国密西根大学心血管中心工作学习，主持各级各类课题多项（包括上海市抗癌协会青年医师“雏鹰计划”项目，上海市科委“扬帆计划”人才培养项目，国家自然科学基金等）
代表性论文：
1. Ling X, Wei S, Ling D, Cao S, Chang R, Wang Q, Yuan Z*: Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury. Cell Mol Biol Lett 2023, 28(1):91.
2. Yuan Z, Wang Q, Tan Y, Wei S, Shen J, Zhuang L, Yang Q, Xu Y, Luo Y: Methylprednisolone alleviates lung injury in sepsis by regulating miR-151-5p/USP38 pathway. Int Immunopharmacol 2024, 138:112548.
3. Yuan Z, Wang Y, Yang Y, Qin X: POLR1D silencing suppresses lung cancer cells proliferation and migration via inhibition of PI3K-Akt pathway. J Cardiothorac Surg 2024, 19(1):322.
4. Chen Z, Wei S, Yuan Z, Chang R, Chen X, Fu Y, Wu W: Machine learning reveals ferroptosis features and a novel ferroptosis classifier in patients with sepsis. Immun Inflamm Dis 2024, 12(5):e1279.
5. Wang Q, Shen J, Luo S, Yuan Z, Wei S, Li Q, Yang Q, Luo Y, Zhuang L: METTL3-m6A methylation inhibits the proliferation and viability of type II alveolar epithelial cells in acute lung injury by enhancing the stability and translation efficiency of Pten mRNA. Respir Res 2024, 25(1):276.
6. Yuan, Z.; Tsou YH.; Zhang XQ.; Huang S.; Yang Y.; Gao M.; Ho W.; Zhao Q.; Ye X.; Xu X. Injectable citrate-based hydrogel as an angiogenic biomaterial improves cardiac repair after myocardial infarction. ACS Applied Materials & Interfaces. 2019 Oct 11. doi: 10.1021/acsami.9b12043.
7. Ju, C.; Sheng, Z.; Wang, Q.; Li, Y.; Wang, X.; Li, S.; Qi, Q.; Yuan, Z*. Advanced glycation end products of bovine serum albumin affect the cell growth of human umbilical vein endothelial cells via modulation of MEG3/miR-93/p21 pathway. Acta Biochim Biophys Sin 2019, 51 (1), 41-50.
8. Yuan, Z.; Kang, L.; Wang, Z.; Chen, A.; Zhao, Q.; Li, H., 17beta-estradiol promotes recovery after myocardial infarction by enhancing homing and angiogenic capacity of bone marrow-derived endothelial progenitor cells through ERalpha-SDF-1/CXCR4 crosstalking. Acta Biochim Biophys Sin 2018, 50 (12), 1247-1256.
9. Yuan, Z.; Li, H.; Chen, A.; Zhao, Q., Second ectopic recurrence of mitral valve myxomas after resection. J Thorac Dis 2018, 10 (7), E516-E519.
10. Yuan, Z.; Li, H.; Qi, Q.; Gong, W.; Qian, C.; Dong, R.; Zang, Y.; Li, J.; Zhou, M.; Cai, J.; Wang, Z.; Chen, A.; Ye, X.; Zhao, Q., Plasma levels of growth differentiation factor-15 are associated with myocardial injury in patients undergoing off-pump coronary artery bypass grafting. Sci Rep 2016, 6, 28221.
11. Li, H.#; Yuan, Z.#; Li, S.; Qi, Q.; Liu, J.; Zhou, M.; Cai, J.; Chen, A.; Wang, Z.; Ye, X.; Zhao, Q., Plasma levels of matrix metalloproteinase 9 in patients undergoing off-pump coronary artery bypass grafting. J Thorac Dis 2017, 9 (4), 1100-1106.
12. Li, S.#; Li, H.#; Yuan, Z.#; Zhang, B.; Chen, A.; Zhou, M.; Liu, J.; Cai, J.; Wang, Z.; Ye, X.; Zhao, Q., Off-pump coronary artery bypass surgery outcomes in patients with ischaemic left ventricular systolic dysfunction with or without detected viable myocardium. Interact Cardiovasc Thorac Surg 2017, 25 (2), 218-224.
13. Li, L.#; Wang, Q. #; Yuan, Z.#; Chen, A.; Liu, Z.; Wang, Z.; Li, H., LncRNA-MALAT1 promotes CPC proliferation and migration in hypoxia by up-regulation of JMJD6 via sponging miR-125. Biochem Biophys Res Commun 2018, 499 (3), 711-718.
14. Yuan, Z.; Li, H.; Sun, Y.; Qiu, J.; Li, J.; Zhou, M.; Chen, A.; Ye, X.; Wang, Z.; Zhao, Q., Pericardial fluid levels of growth differentiation factor 15 in patients with or without coronary artery disease: a prospective study. Ann Transl Med. 2020 Feb;8(4):113.
Dr. Yuan is an attending surgeon of thoracic surgery; He has long been engaged in Clinical and basic research on acute lung injury and myocardial infarction. He is a member of IASLC and Shanghai Anti-Cancer Association. From 2016 to 2018, he served as a Research Assistant at the Augusta University and a visiting postdoctoral researcher at the Cardiovascular Center of the University of Michigan in the United States. He presided a number of various grants at all levels (including the Shanghai Anti-Cancer Association Young Physician program, Shanghai Municipal Science and Technology Commission “Sailing program”, National Natural Science Foundation, etc.)
