一、主持的主要科研项目(Leading major research projects):
国家自然科学基金面上项目,82171565,Nrf2调控OMA1-OPA1通路影响线粒体动力学改善老年肌少症的机制研究,2022-01至2025-12,55万元
国家自然科学基金青年项目,81800795,Nrf2调控FoxO1信号通路改善术后骨骼肌功能的机制研究,2019-01至2021-12,21万元
美高梅附属第十人民医院国自然院内培育面上项目,Nrf2-TBK1-OPA1通路在肌肉减少症中的作用及机制研究,2021至2022,10万元
美高梅附属第十人民医院国自然院内培育青年项目,Nrf2调控FoxO1通路抑制老年个体术后骨骼肌蛋白降解的机制研究,2017-10至2019-09,6万元
美高梅优秀青年项目,2.5万。
上海市卫生和计划生育委员会,20184Y0301,术前锻炼干预肌少症对改善老年胃癌患者术后短期临床结局的有效性研究,2019-01至2021-12,5万元
美高梅附属第十人民医院引进人才(优秀青年)科研启动经费,2018/05(不过期),20万
二、荣誉获奖(Honours and Awards)
国际NOSES手术视频大赛,中国医师协会结直肠肿瘤专委会,亚军,2020
受邀参加2020年韩国国际胃癌会议(KINGCA)并进行学术汇报
加速康复外科病例演讲点评交流赛全国总决赛,中华普通外科杂志,三等奖,2018
北京医学科技奖,北京医学会,一等奖,2021,排名第10
全国肿瘤营养先进个人 中国抗癌协会肿瘤营养专业委员会,2022
全国肿瘤营养菁莪奖 中国抗癌协会肿瘤营养专业委员会,2021
全国肿瘤营养新苗奖 中国抗癌协会肿瘤营养专业委员会,2020
全国肿瘤营养新苗奖 中国抗癌协会肿瘤营养专业委员会,2019
人参联合营养支持改善术后疲劳综合征的基础与临床研究,上海市中医药学会,二等奖,2016,排名第2
肠外肠内营养支持治疗的基础研究及临床应用,浙江省人民政府,二等奖,2013,排名第9
第八届上海市肠外肠内营养学术年会“青年演讲比赛”,上海市医学会 二等奖,2017
第十届全国肿瘤营养大会优秀论文,中国抗癌协会肿瘤营养专业委员会,二等奖,2021
中华医学会第十三届全国肠外肠内营养学学术会议大会优秀论文,中华医学会肠外肠内营养学分会,二等奖,2019
中华医学会第十三届全国肠外肠内营养学学术会议大会优秀论文,中华医学会肠外肠内营养学分会,三等奖,2019
三、近五年发表的代表性论著(Representatives published in the past five years):
Liu L, He J, Sun G, et al. The N6-methyladenosine modification enhances ferroptosis resistance through inhibiting SLC7A11 mRNA deadenylation in hepatoblastoma. Clin Transl Med. 2022;12(5):e778. (IF: 11.492),论著,共同通讯作者
Zhuang CL, Zhang FM, Xu HX, et al. Reference values of low body mass index, mid-upper arm circumference, and calf circumference in cancer patients: A nationwide multicenter observational study Nutrition. 2022;99-100:111688. (IF: 4.008),论著,第一作者
Zhuang CL, Dong QT, Shi HP, et al. Cachexia Versus Sarcopenia in Clinical Characteristics and Prognostic Value After Radical Gastrectomy for Gastric Cancer: A Large-Scale Prospective Study. Ann Surg Oncol. 2022;29(4):2348-2358. (IF: 5.344),论著,第一作者
Zhang FM, Zhang XZ, Shi HP, Zhang Z, Wang SL, Shen ZL, Chen XL, Shen X, Yu Z, Zhuang CL. Comparisons and Impacts of the Basic Components of Sarcopenia Definition and Their Pairwise Combinations in Gastric Cancer: A Large-Scale Study in a Chinese Population. Front Nutr. 2021;8:709211. Published 2021 Oct 20. doi:10.3389/fnut.2021.709211 (IF: 6.576) ,论著,通讯作者
Zhang FM, Zhang XZ, Zhu GL, Lv LQ, Yan XL, Wu WX, Wang SL, Chen XL, Zhuang CL, Yu Z. Impact of sarcopenia on clinical outcomes of patients with stage I gastric cancer after radical gastrectomy: A prospective cohort study [published online ahead of print, 2021 Aug 17]. Eur J Surg Oncol. 2021;S0748-7983(21)00693-4. doi:10.1016/j.ejso.2021.08.021 (IF: 4.424),论著,共同通讯作者
Zhuang CL#, Zhang FM, Wang Z, Jiang X, Wang F, Liu ZC. Precision functional sphincter-preserving surgery (PPS) for ultralow rectal cancer: a natural orifice specimen extraction (NOSE) surgery technique. Surg Endosc. 2021 Jan;35(1):476-485. doi: 10.1007/s00464-020-07989-4. Epub 2020 Sep 28. PMID: 32989539,(IF: 4.583),论著,第一作者
Zhuang CL#, Zhang FM, Li W, Wang KH, Xu HX, Song CH, Guo ZQ, Shi HP. Associations of low handgrip strength with cancer mortality: a multicentre observational study. J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1476-1486. doi: 10.1002/jcsm.12614. Epub 2020 Sep 10. PMID: 32910535. (IF: 12.912),论著,第一作者
Zhang FM, Chen XL, Wu Q, Dong WX, Dong QT, Shen X, Shi HP, Yu Z, Zhuang CL#. Development and validation of nomograms for the prediction of low muscle mass and radiodensity in gastric cancer patients. Am J Clin Nutr. 2021 Feb 2;113(2):348-358. doi: 10.1093/ajcn/nqaa305. PMID: 33300037. (IF: 7.041),论著,通讯作者
Zhuang C. L.#, Shen X., Zou H. B., Dong Q. T., Cai H. Y., Chen X. L., Yu Z., Wang S. L., EWGSOP2 Versus EWGSOP1 for sarcopenia to predict prognosis in patients with gastric cancer after radical gastrectomy: analysis from a large-scale prospective study. Clin Nutr. 2020 Jul;39(7):2301-2310. Doi: org/ /10.1016/j.clnu.2019.10.024 (IF: 7.321),论著,第一作者
Zou HB, Yan XL, Dong WX, Yu DY, Zhang FM, Zhou LP, Shen ZL, Cai GJ, Zhuang CL#, Yu Z. Sarcopenia is a predictive factor of poor quality of life and prognosis in patients after radical gastrectomy. Eur J Surg Oncol. 2021 Aug;47(8):1976-1984. doi: 10.1016/j.ejso.2021.03.004. Epub 2021 Mar 6. PMID: 33714648. (IF: 4.424),论著,共同通讯作者
Zhang F. M., Ma B.W., Huang Y. Y., Chen W. Z., Chen J. J., Dong Q. T., Chen W. S., Chen X.L., Shen X., Yu Z., Zhuang C.L.#, Laparoscopic colorectal cancer surgery reduces the adverse impacts of sarcopenia on postoperative outcomes: A propensity score-matched analysis. Surgical Endoscopy. 2020 Oct;34(10):4582-4592. Epub 2019 Nov 18. (IF: 4.583),论著,通讯作者
Zhuang C. L.#, Shen X., Huang Y. Y., Zhang F. M., Chen X. Y., Ma L. L., Chen X. L., Yu Z., Wang S. L. Myosteatosis predicts prognosis after radical gastrectomy for gastric cancer: A propensity score-matched analysis from a large-scale cohort. Surgery. 2019,166(3):297-304. (IF: 3.983),论著,第一作者
Chen X.Y., Zhang X.Z., Ma B.W., Li B., Zhou D.L., Liu Z.C., Chen X.L., Shen X., Yu Z., Zhuang C.L.#, A comparison of four common malnutrition risk screening tools for detecting cachexia among patients with curable gastric cancer. Nutrition. 2020 Feb;70:110498. Epub 2019 Apr 26. Doi: org/10.1016/j.nut.2019.04.009. (IF: 4.001),论著,通讯作者
Zhou LP, Yu DY, Ma BW, Shen ZL, Zou HB, Zhang XZ, Yan XL, Zhuang CL#, Yu Z. Feasibility of substituting handgrip strength for muscle mass as a constituent standard in the Global Leadership Initiative on Malnutrition for diagnosing malnutrition in patients with gastrointestinal cancers. Nutrition. 2020 Oct 30;84:111044. doi: 10.1016/j.nut.2020.111044. Epub ahead of print. PMID: 33517155. (IF: 4.001),论著,共同通讯作者
Ma B. W., Chen X. Y., Fan S. D., Zhang F. M., Huang D. D., Li B., Shen X., Zhuang C. L.#, Yu Z. Impact of sarcopenia on clinical outcomes after radical gastrectomy for patients without nutritional risk. Nutrition. 2019,6161-66. (IF: 4.001),论著,共同通讯作者
Huang D. D., Fan S. D., Chen X. Y., Yan X. L., Zhang X. Z., Ma B. W., Yu D. Y., Xiao W. Y., Zhuang C. L.#, Yu Z. Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner. Experimental gerontology. 2019,11961-73. (IF: 4.034),论著,共同通讯作者
Chen X. Y., Li B., Ma B. W., Zhang X. Z., Chen W. Z., Lu L. S., Shen X., Zhuang C. L.#, Yu Z. Sarcopenia is an effective prognostic indicator of postoperative outcomes in laparoscopic-assisted gastrectomy. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2019. (IF: 4.420),论著,共同通讯作者
Wang S. L., Ma L. L., Chen X. Y., Zhou D. L., Li B., Huang D. D., Yu Z., Shen X., Zhuang C. L.#. Impact of visceral fat on surgical complications and long-term survival of patients with gastric cancer after radical gastrectomy. Eur J Clin Nutr. 2018,72(3):436-445. (IF: 4.010),论著,通讯作者
Ye X. J., Ji Y. B., Ma B. W., Huang D. D., Chen W. Z., Pan Z. Y., Shen X., Zhuang C. L.#, Yu Z. Comparison of three common nutritional screening tools with the new European Society for Clinical Nutrition and Metabolism (ESPEN) criteria for malnutrition among patients with geriatric gastrointestinal cancer: a prospective study in China. Bmj Open. 2018,8(4):e019750. (IF: 2.693),论著,共同通讯作者
Zhou C. J., Zhang F. M., Zhang F. Y., Yu Z., Chen X. L., Shen X., Zhuang C. L.#, Chen X. X. Sarcopenia: a new predictor of postoperative complications for elderly gastric cancer patients who underwent radical gastrectomy. The Journal of surgical research. 2017,211137-146. (IF: 2.194),论著,共同通讯作者
Huang D. D., Zhou C. J., Wang S. L., Mao S. T., Zhou X. Y., Lou N., Zhang Z., Yu Z., Shen X., Zhuang C. L.#. Impact of different sarcopenia stages on the postoperative outcomes after radical gastrectomy for gastric cancer. Surgery. 2017,161(3):680-693. (IF: 3.980),论著,通讯作者
Huang D. D., Ji Y. B., Zhou D. L., Li B., Wang S. L., Chen X. L., Yu Z., Zhuang C. L.#. Effect of surgery-induced acute muscle wasting on postoperative outcomes and quality of life. The Journal of surgical research. 2017,21858-66. (IF: 2.194),论著,通讯作者
Zhuang C. L.#, Huang D. D., Pang W. Y., Zhou C. J., Wang S. L., Lou N., Ma L. L., Yu Z., Shen X. Sarcopenia is an Independent Predictor of Severe Postoperative Complications and Long-Term Survival After Radical Gastrectomy for Gastric Cancer: Analysis from a Large-Scale Cohort. Medicine. 2016,95(13):e3164. (IF: 1.881),论著,第一作者
Zhou C. J., Chen F. F., Zhuang C. L.#, Pang W. Y., Zhang F. Y., Huang D. D., Wang S. L., Shen X., Yu Z. Feasibility of radical gastrectomy for elderly patients with gastric cancer. European journal of surgical oncology. 2016,42(2):303-311. (IF: 4.423),论著,共同第一作者
Wang S. L., Zhuang C. L.#, Huang D. D., Pang W. Y., Lou N., Chen F. F., Zhou C. J., Shen X., Yu Z. Sarcopenia Adversely Impacts Postoperative Clinical Outcomes Following Gastrectomy in Patients with Gastric Cancer: A Prospective Study. Annals of surgical oncology. 2016,23(2):556-564. (IF: 5.343),论著,共同第一作者
Lou N., Chi C. H., Chen X. D., Zhou C. J., Wang S. L., Zhuang C. L.#, Shen X. Sarcopenia in overweight and obese patients is a predictive factor for postoperative complication in gastric cancer: A prospective study. European journal of surgical oncology. 2016. (IF: 4.423),论著,共同通讯作者
Huang D. D., Chen X. X., Chen X. Y., Wang S. L., Shen X., Chen X. L., Yu Z., Zhuang C. L#. Sarcopenia predicts 1-year mortality in elderly patients undergoing curative gastrectomy for gastric cancer: a prospective study. Journal of cancer research and clinical oncology. 2016,142(11):2347-2356. (IF: 4.552),论著,通讯作者
Chen F. F., Zhang F. Y., Zhou X. Y., Shen X., Yu Z., Zhuang C. L.#. Role of frailty and nutritional status in predicting complications following total gastrectomy with D2 lymphadenectomy in patients with gastric cancer: a prospective study. Langenbeck