大肠癌发病机理的基础研究； 结直肠癌的精准诊断、精准微创手术治疗 Basic research for the pathogenesis of colorectal cancer； Accurate diagnosis of colorectal cancer, and precise laparoscopic surgery
美国结直肠医师学会荣誉委员 中国医师协会外科医师分会肛肠外科医师委员会主任委员 中国医师协会结直肠肿瘤专业委员会经自然腔道取标本手术（NOSES）专业委员会副主任委员 中国医师协会结直肠肿瘤分会外科委员会副主任委员 中国医师协会结直肠肿瘤专业委员会常务委员 中国中西医结合医学会大肠肛门病专业委员会顾问 上海市普外专业委员会大肠肛门病学组顾问 中国抗癌学会大肠癌专业委员会常委 中国医师协会结直肠分会常委 卫生部大肠癌规范化诊疗专家委员会委员 英国《Colorectal Disease》,美国《Disease of Colon and Rectum》，意大利《Techniques in Coloproctology》,《中华外科杂志》，《中华胃肠外科杂志》，《中华普通外科杂志》等编委。 American society of colorectal honorary fellow Director of the Chinese medical doctor association committee member surgeon branch of anorectal surgeons Colorectal tumor professional committee, China physicians association, and nature orifice specimen extraction surgery (NOSES), deputy director of professional committee members The Chinese medical doctor association branch of colorectal cancer surgery committee, deputy director of the committee members Standing committee of colorectal tumor professional committee, China physicians association The anus disease combine traditional Chinese and western medicine medical association professional committee of China Consultants of Shanghai general professional committee and anus epidemiology group society member of Colorectal cancer professional committee The standing committee of the Chinese medical doctor association colorectal section The ministry of health of colorectal cancer diagnostic expert committee Editors of < journal of the Chinese general surgery>
国自然项目：
1、2017年，国自然面上项目，IncRNA-SLC25A25-AS1介导直肠癌放疗抵抗的作用机制研究，54万。
2、2015年，国自然面上项目，IGF-1促进多药耐药蛋白表达介导直肠癌放疗抵抗的分子机制，57万。 论文：
1.a scoring system to predict development of bone metastasis after radical resection of colorectal cancer. Anticancer research. 2017.
2.systemic analysis of different colorectal cancer cell lines and TCGA datasets identified IGF-1R/EGFR-PPAR-CASPASE axis as important indicator for randiotherapy sensitivity. Gene. 2017.
3.miR-320b suppresses cell proliferation by targeting c-Myc in human colorectal cancer cells. BMC Cancer. 2015.
4.Endoplasmic reticulum ribosome-binding protein 1, RRBP1, promotes progression of colorectal cancer and predicts an unfavourableprognosis. British journal of cancer.2015
5.More advanced or aggressive colorectal cancer is associated with a higher incidence of‘high-grade intraepithelial neoplasia’ on biopsy-based pathological examination, Tech Coloproctol ,2012.
6.Red and processed meat intake and risk of colorectal adenomas: a meta-analysis of observational studies,2012,Int.J.Cancer.
7. DNA topoisomeraseⅡalpha: a favorable prognostic factor in colorectal caner. Int J Colorectal Dis 2011.
8. Suppression of lung cancer metastasis-related protein 1 (LCMR1) inhibits the growth of colorectal cancer cells, Molecular Biology Reports,
9. Residual skin tags following Procedure for Prolapse and Hemorrhoids should be differentiated from recurrence,World J Surg, 2011.
10. Rectal Perforation After Procedure for Prolapse and Hemorrhoids: Possible Causes. Diseases of the Colon & Rectum, 2010.
11. Diagnosis and treatment of diffuse cavernous hemangioma of the rectum: report of 17 cases. World J Surg, 2010.
12. Patterns of lymph node metastasis are different in colon and rectal carcinomas, World J Gastroenterol, 2010.
