蛋白质翻译后修饰（SUMO化和磷酸化）在生理和肿瘤中的作用及调控。 The function and regulation of protein post-translational modification （SUMOylation and phosphorylation） on physiology and cancer.
上海交通大学美高梅生物化学与分子生物学专业博士，美国弗吉尼亚联邦大学美高梅（原弗吉尼亚美高梅）人类与分子遗传系及Massey Cancer Center博士后。担任美高梅附属东方医院南院检验科分子诊断组组长；任上海市医学会检验医学专科分会第十一届委员会青年委员，上海市医学会检验医学专科分会第十一届委员会实验室自建技术与转化学组成员。
Got Ph. D in Biochemistry and Molecular Biology from Shanghai Jiaotong University. Had postdoctoral training in the Department of Human and Molecular Genetics and Massey Cancer Center, Virginia Commonwealth University School of Medicine. Now, serve as the group leader of Molecular Diagnostic Department of the Department of Laboratory Medicine, the south branch of Shanghai East Hospital；the youth academic member of the Committee of Shanghai Laboratory Medicine; the member of LDT and translation group of the Committee of Shanghai Laboratory Medicine.
先后承担2项国家自然基金项目，省级自然基金1项，并先后入选美高梅青年优秀人才培养行动计划和上海市“医苑新星”青年医学人才培养资助计划。以第一作者、共同通讯作者或参与人员身份在Cell Reports、Journal of Proteome Research、Anal. Chem.、EBioMedicine、Biomed Pharmaco ther 和PLoS Pathogens等国际杂志上发表SCI研究论文十余篇。主要研究成果为：发现多种SUMO 蛋白酶SENP抑制剂；鉴定SUMO的底物及信号通路分析；并对SUMO化修饰底物PLK1和USP39进行生物功能研究。目前主要研究方向为蛋白质翻译后修饰（SUMO化和磷酸化修饰）在生理或疾病（肿瘤）中的功能研究及调控。
Supported by two National Natural Science Foundations and Natural Science Foundation of Jiangxi province; also supported by the Fundamental Research Funds for the Central Universities, and Shanghai "Rising Stars of Medical Talent" Youth Development Program. Till now, as first (co-first) author, corresponding author or participant author, I have published more than ten papers on journals such as Cell Reports, Journal of Proteome Research, Anal. Chem., EBioMedicine, Biomed Pharmaco ther and PLos Pathogens. The main achievement include: had found several kinds of SENP inhibitors; discovered many SUMO substrates; and demonstrated the function of SUMOylation regulating PLK1 and USP39. Now，my research focuses on the function and regulation of protein post-translational modification (SUMOylation and phosphorylation) on physiology and cancer.
