肿瘤发病机制、生物标志物筛查及免疫治疗的基础和临床研究 The basic and clinical research of tumor pathogenesis, biomarker screening and immunotherapy
美高梅附属同济医院检验科分子遗传组学科带头人Academic leader of Molecular Genetics, Department of Clinical Laboratory, Tongji Hospital of Tongji University;
上海市医学会检验医学专科分会青年委员Youth Committee, Shanghai Medicine Association of Laboratory Medicine;
白求恩精神研究会检验医学分会青年委员会副主任委员Youth Deputy Director Committee, Bethune Spirit Association of Laboratory Medicine;
上海市中西医结合学会医学检验专业委员会青年委员Youth Committee, Shanghai Chinese and Western Medicine Association of Laboratory Medicine;
白求恩精神研究会区域检验专委会委员Committee, Bethune Spirit Association of Regional Laboratory Medicine;
《国际检验医学》、《检验医学与临床》、《Clinica Chimica Acta》杂志审稿专家The Reviewer of International Journal of Laboratory Medicine, Laboratory Medicine and Clinical, Clinica Chimica Acta;
上海市政府采购评审专家Evaluation Expert of Shanghai Municipal Government Procurement
立项课题:第一负责人主持课题:
1.2020.1-2023.12 国家自然基金面上项目(81974314) ,55万元;
2.2019.6-2022.5 上海市同济医院临床研究培育重点项目[ITJ(ZD)1905],25万元;
3.2019.5-2022.4 上海市自然科学基金(19ZR1448800), 20万元;
4.2019.4-2022.3 上海市科委医学引导类项目(19411964800), 20万元;
5.2018.10-2019.9 上海市同济医院国家自然科学基金培育项目(GJPY1804) ,5万元;
6.2018.1-2020.12 上海市科委智慧即时检测示范应用研究(17DZ1930301) ,3万元;
7.2011.1-2013.12 国家自然科学基金青年项目(81001205),20 万元;
8.2010.10-2012.9 上海交通大学附属第九人民医院院级课题, 2 万元
发表SCI论文:第一/通讯作者:
1.Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p-TGF-β1 axis. Mol Cancer, 2020, 19:117-31;
2.Long Non-coding RNA CCAT1 promotes colorectal cancer progression by regulating miR-181a-5p expression. Aging (Albany NY). 2020, 12(9): 8301-8320;
3.Exosomal miR-183-5p Promotes Angiogenesis in Colorectal Cancer by Regulation of FOXO1. Aging (Albany NY). 2020, 12(9): 8352-8371;
4.Exosomal KRAS mutation promotes the formation of tumor-associated neutrophil extracellular traps and causes deterioration. Cell Commun Signal. 2020, 18(1):52;
5.Long non-coding RNA HOTTIP enhances IL-6 expression to potentiate immune escape of ovarian cancer cells by upregulating the expression of PD-L1 in neutrophils. Journal of Experimental & Clinical Cancer Research. 2019, 38:1-15;
6.Myeloid cell-derived LL-37 promotes lung cancer growth by activating Wnt/β-catenin signaling. Theranostics. 2019, 9(8):2209-23;
7.Bronchoalveolar lavage fluid-derived exosomes: a novel role contributing to lung cancer growth. Frontiers in Oncology. 2019,197:1-11;
8.A novel humanized anti-PD-1 monoclonal antibody potentiates therapy in oral squamous cell carcinoma. Ivest New Drug. 2018, 26(6):1-12;
9.A deficiency in cathelicidin reduces lung tumor growth in NNK/NTHi-induced A/J mice. Am J Cancer Res. 2018, 8:1190-9;
10.The value of red blood cell distribution width in diagnosis of patients with colorectal cancer. Clinica Chimica Acta. 2018, 479: 98-102;
11.Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target. Oncol Rep. 2018, 39: 209-216;
12.A novel bispecific c-MET/PD-1 antibody with therapeutic potential in solid cancer. Oncotarget. 2017, 8: 29067-79;
13.Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation. Oncol Rep. 2013, 29:1701-6;
14.Role of toll-like receptor 4 on the immune escape of human oral squamous cell carcinoma and resistance of cisplatin-induced apoptosis. Mol Cancer. 2012. 11:1-12