承担的主要课题：
1.国家自然科学基金青年项目: “SV2A配体以单核细胞为靶点的抗动脉粥样硬化效应与机制研究”。项目负责人。
2.上海市浦东新区科技发展基金：“PCSK9介导的脂质代谢调控急性脑缺血再灌注后内源性神经干细胞增殖和分化的机制研究”。项目负责人。
3.上海市浦东新区卫生健康委员会人才项目-学科带头人。主攻课题：“急性缺血性卒中后PCSK9对“神经元-星形胶质细胞”炎症反应中关键分子的调控和神经保护效应”。项目负责人。
4.上海市重大临床研究项目：“注射用替奈普酶治疗超时间窗急性缺血性卒中大血管闭塞患者的前瞻性、多中心、开放性、终点盲法、分层区组随机、平行阳性对照临床试验”。中心负责人。
5.国家重点研发计划：“神经系统和心脏相关重大疾病组织干细胞和病理组织库”。主要参与人。
6.国家自然科学基金面上项目：“SV2A配体调控阿尔茨海默病关键神经免疫细胞功能的作用及其机制研究”。主要参与人。
Major projects undertaken:
1. National Natural Science Foundation of China Youth Project, "The anti-atherogenic effect and mechanism of SV2A ligand targeting monocytes". Project leader.
2. Shanghai Pudong New Area Science and Technology Development Foundation, "PCSK9-mediated lipid metabolism regulates the proliferation and differentiation of endogenous neural stem cells after acute cerebral ischemia-reperfusion". Project leader.
3. Shanghai Pudong New Area Health Commission Talent Project - Discipline leader. Main topic: "Regulation and neuroprotective effects of PCSK9 on key molecules in neuron-astrocyte inflammatory response after acute ischemic stroke". Project leader.
4. Shanghai Major clinical research project: "A prospective, multicenter, open, end-blind, stratified block randomized, parallel positive controlled clinical trial of tenecteplase for injection in patients with large-vessel occlusion of acute ischemic stroke beyond the time window". Head of the center.
5. National Key Research and Development Program: "Tissue stem cells and pathological Tissue Bank of major diseases related to the nervous system and heart". The main player.
6. National Natural Science Foundation of China (NSFC) project: "The role and mechanism of SV2A ligand in regulating the function of key neuroimmune cells in Alzheimer's disease". The main player.
近5年发表SCI文章：
SCI articles published in the past five years:
1.Li G, Lin Y, Yang J, Anderson CS, Chen C, Liu F, Billot L, Li Q, Chen X, Liu X, Ren X, Zhang C, Xu P, Wu L, Wang F, Qiu D, Jiang M, Peng Y, Li C, Huang Y, Zhao X, Liang J, Wang Y, Wu X, Xu X, Chen G, Huang D, Zhang Y, Zuo L, Ma G, Yang Y, Hao J, Xu X, Xiong X, Tang Y, Guo Y, Yu J, Li S, He S, Mao F, Tan Q, Tan S, Yu N, Xu R, Sun M, Li B, Guo J, Liu L, Liu H, Ouyang M, Si L, Arima H, Bath PM, Ford GA, Robinson T, Sandset EC, Saver JL, Sprigg N, van der Worp HB, Song L; INTERACT4 investigators; INTERACT4 Investigators. Intensive Ambulance-Delivered Blood-Pressure Reduction in Hyperacute Stroke. [J]. N Engl J Med,2024,390(20):1862-1872. DOI: 10.1056 / NEJMoa2314741
2.Yue Sun, Mengni Jiang, Xiang Long, Yongzhen Miao, Huanhuan Du, Ting Zhang, Xuejun Ma, Yue Zhang*, Hongrui Meng. Transcriptomic Analysis of Lipid Metabolism Genes in Alzheimer's Disease: Highlighting Pathological Outcomes and Compartmentalized Immune Status. Journal of Molecular Neuroscience. 2024, 74:55.
3.Yaling Zheng, Tianrui Zhu, Gang Li, Luran Xu*, Yue Zhang*. PCSK9 inhibitor protects against ischemic cerebral injury by attenuating inflammation via the GPNMB/CD44 pathway. International Immunopharmacology, 2023. (126)111195.
4.Xueqi Wang, Hao Zhang, Qi Wang, Gang Li, Hao Shen, Yaping Xiao, Luran Xu, Yuming Long, Chen Chen, Zhengyu Huang*, Yue Zhang*. Effect of intravenous thrombolysis on core growth rate in patients with acute cerebral infarction. Frontiers in Neurology. 2023. Feb 23;14:1096605. doi: 10.3389/fneur.2023.1096605. eCollection 2023.
5. Yongjia Shao, Zijian Wang, Bin Ji, Hang Qi, Shangci Hao, Gang Li, Yue Zhang* and Qian XI*. Diffusion Tensor Imaging Study of Olfactory Identification Deficit in Patients with Mild Cognitive Impairment. Frontiers in Aging Neuroscience. 2021,13.doi:10.3389/fnagi.2021.765432.
6. Yue Zhang, Jingyi Li, Chengzhang Liu, Hongxiang Yu, Chen Chen, Chonglei Bi, Chongqian Fang, Hai Ma, Aimin Li, Qing Dong, Lishun Liu, Binyan Wang, Xiao Huang, Xiaoshu Cheng, Pierre Zalloua, Xiping Xu, Yong Huo, Gang Li*. High-Density Lipoprotein Cholesterol and the Risk of First Ischemic Stroke in a Chinese Hypertensive Population. Clinical Interventions in Aging. 2021,16:801-810.
7. Kui Chen, Meng-Ruo Guo, Yue Zhang, Gang Li, Yi Liu*, Bei Zhang*. Association between MMP16 rs60298754 and clinical phenotypes of Parkinson’s disease in southern Chinese. Neurol Sci. 2020 Nov 25. doi: 10.1007/s10072-020-04894-5.
8. Ying Wang, Yue Zhang, Jing Zhang, Jing Lu, Chao-wen Yang, Jian Zhao, Gang Li, Zhong-min Liu*, Ying Lei*. Generation of a human control PBMC derived iPS cell line TUSMi001-A from a healthy male donor of Han Chinese genetic background. Stem Cell Research. 2017,2522-25.
9. Yue Zhang, Ying Li, Lian Zuo, Huan Bao, Xiahong Xu, Junjie Hao, Xin Wang, Gang Li*. Levetiracetam Prevents Perforin Mediated Neuronal Injury Induced by Acute Cerebral Ischemia Reperfusion. Mol Neurobiol. 2016,53(8):5480–5491.
