主要研究方向为脑卒中早期全程康复,主持国家自然科学青年基金1项,上海市科委扬帆人才1项,院攀登人才项目1项,参与国家级和市级项目多项。发表中英文科学论著多篇。曾获得上海市科技进步奖三等奖及上海市医学科技奖二等奖。
●主持及参与项目
1. 国家自然科学基金青年基金,P2Y6R介导小胶质细胞吞噬ECS在双侧密集训练改善卒中后认知障碍中的作用及机制研究,82101537,2022.1.1-2024.12.31, 30万元,在研,主持
2.上海市市科委扬帆计划,基于知识图谱的脑卒中康复信息支持和生物机制研究,19YF1438400,2019.5.1-2022.4.30,20万元,结题,主持
3. 美高梅附属第十人民医院攀登人才计划项目,2018SYPDRC038,脑卒中康复的组学模型建立,2018.09-2024.08,22万元,在研,主持
4.国家自然科学基金委员会, 面上项目, 82071206, LncRNA Kcnq1ot1介导DGCR8的SUMO1修饰调控神经元凋亡的机制研究, 2021.01 -2024.12, 55万元, 在研, 主要参与人
5.上海市科学技术委员会,重大课题,中枢神经系统疾病引发的姿势控制障碍精准康复策略的多中心临床研究,2022.10-2025.09,30万元,在研,主要参与人
6.上海市科学技术委员会医学引导类项目,18411961700,基于数据挖掘的脑卒中患者上下肢双侧密集训练与认知整合策略研究,2018.09-2021.08,25万元,结题,主要参与人
7.上海市科委生物医药领域科技支撑项目,19441908500,适用于脑卒中患者的便携经济性上肢康复机器人实验室样机研制,2019.04-2022.03,25万元,结题,主要参与人
8.上海市科学技术委员会,2017年度“科技创新行动计划”, 17411950100, 早期认知功能障碍分级诊疗的多中心临床研究, 2017.10- 2021.09, 300万元, 结题, 主要参与人
●发表文献
[1]孟桂林,艾自胜,兰海丹等.基于临床医学本科毕业生学业成绩的综合评价模型与教学改革思考[J].医学信息,2013,26(12):7-8.
[2]兰海丹,孟桂林,杨金松等.临床医学本科毕业生学业成绩综合评价[J].中国高等医学教育,2013,(5):51-53.
[3]孟桂林,梁兴伦,赵延欣,傅近,刘学源,中西医结合发展中国特色医学模式[J].中国医药导报,2015,12,(1):98-101
[4] Meng G, Tan Y, Fang M, et al. Meteorological factors related to emergency admission of elderly stroke patients in shanghai: analysis with a multilayer perceptron neural network[J]. Medical science monitor: international medical journal of experimental and clinical research, 2015, 21: 3600.
[5] Meng G L, Tan Y, Fang M, et al. Paradoxical Elevation of High Density Lipoprotein Cholesterol in Association with Lacunar-Type Cerebral Infarction[J]. Medical science monitor: international medical journal of experimental and clinical research, 2015, 21: 1872.
[6] Tsutsui S, Ding Y, Meng G. Machine Reading Approach to Understand Alzheimer's Disease Literature[J]. DTMBIO 2016, 2016.
[7] Yan H, Liu B, Meng G, et al. The influence of individual socioeconomic status on the clinical outcomes in ischemic stroke patients with different neighborhood status in Shanghai, China[J]. International Journal of Medical Sciences, 2017, 14(1): 86.
[8] Meng G, Ma X, Li L, Tan Y, Liu X, Liu X, Zhao Y. Predictors of early-onset post-ischemic stroke depression: a cross-sectional study. BMC Neurol. 2017, 17;17(1):199.
[9] Meng GL, Tan Y, Yu J, Jin A, Zhao Y, Liu X. Short-term efficacy of hand-arm bimanual intensive training on the upper arm function of acute stroke patients: a single center randomized controlled trial. Front Neurol. 2018 Jan 19;8:726.
[10] Guilin Meng, Xiaoye Ma, Gengping Zhang, Xiaolin Hu, Aiping Jin, Yanxin Zhao, Xueyuan Liu. Application of Ferulic Acid for Alzheimer’s Disease: Combination of Text Mining and Experimental Validation. Frontiers in Neuroinformatics, 2018, 12 :31
[11] Guilin Meng, Yong Huang, Qi Yu, Ying Ding, Song Min. Adopting Text Mining on Rehabilitation Therapy Repositioning for Stroke. Front Neuroinform. 2019;13:17. Published 2019 Mar 19. doi:10.3389/fninf.2019.00017
[12] Yu J, Meng G, Xu S, Chen P, Liu X, Zhao Y, Liu X, Jin A. Association between Dix-Hallpike test parameters and successful repositioning maneuver in posterior semicircular canal benign paroxysmal positional vertigo: a case-control study. Ann Transl Med. 2020;8(6):286.
[13] Guo S, Lin Y, Ma X, Zhao Y, Jin A, Liu X, Sun L, Meng G. Long-Term Safety and Efficacy of Antiplatelet Therapy in Patients With Cerebral Infarction With Thrombocytopenia. Clin Appl Thromb Hemost. 2021 Jan-Dec;27:1076029620980067.
[14] Ma X, Meng G, Zhang M, Zhao Y, Zhou Y, Zhao Y, Liu X. Exploring Potential Biomarkers Underlying the Pathogenesis of Alzheimer's Disease by Bioinformatics Gene Analysis. Ann Clin Lab Sci. 2021 Mar;51(2):198-205.
[15] Xu S, Meng G, Chen P, Fang M, Jin A. Multidimensional intervention in individuals with mild cognitive impairment: a pilot nonrandomized study. Ann Palliat Med. 2021 Feb;10(2):1539-1547.
[16] Yu J, Gu Y, Meng G, Zhu X, Wang W, Liu X, Jin A. Nystagmus Parameters of Supine Roll Test Correlates With Prognosis After Repositioning Maneuver in Horizontal Semicircular Canal Benign Paroxysmal Positional Vertigo. Front Neurol. 2021 Dec 6;12:790430. doi: 10.3389/fneur.2021.790430.
[17] Meng GL, Ma XY, Chen PF, Jin A, Liu X. Effect of Early-Integrated Robot-Assisted Gait Training on Motor and Balance in Patients with Acute Ischemic Stroke: a Single-Blinded Randomized Controlled Trial. Therapeutic Advances in Neurological Disorders. 2022 October. (accepted)
●专利
[1]孟桂林, 赵延欣, 刘学源.一种预测急诊就诊量的方法以及医院管理系统:中国,CN201510342160.9[P].2015-09-30.
[2] 尹刚刚,张开颜,肖彼得,金爱萍,孟桂林.一种下肢助力外骨骼机器人的步态控制方法和控制系统:CN201810950690.5[P].2018-08-20.
[3]贾杰,王吴东,金爱萍,孟桂林,尹刚刚.一种软性下肢助力外骨骼:CN201810950688.8[P].2018-08-20.
[4]金爱萍,刘学源,孟桂林,尹刚刚,王吴东,陈忠哲. 应用于康复训练的气体管路系统及其控制方法:CN202110045001.8[P]. 2021-06-01.
[5]刘学源,金爱萍,孟桂琳,尹刚刚,王吴东,陈忠哲. 一种上肢关节康复训练方法及装置:CN202110070755.9[P]. 2021-06-04.
●成果奖励
[1] 孟桂林(4/7),血管危险因素对认知功能障碍影响的临床和基础研究,上海医学科技奖奖励委员会, 上海市医学科技奖, 省部二等奖, 2015
(刘学源; 赵延欣; 方珉; 孟桂林; 谈艳; 李强; 张佩)
[2] 孟桂林(5/9),早期认知功能障碍的发病机制与临床干预研究, 上海市人民政府, 上海市科技进步奖, 省部级三等奖, 2017
(刘学源; 赵延欣; 金爱萍; 谈艳; 孟桂林; 方珉; 陆悠; 谢珺超; 钟时颖)