1. 亚太痛风联盟 常委 2017-2020 2. 中华医学会内分泌学会高尿酸学组，委员 3. 上海市医学会内分泌学会委员 4. 上海市医学会内分泌学会委员 高尿酸血症学组组长
科研项目Extramural Grants/Award Amount (As Principal Investigator):
1.人工基因回路设计、构建及其用于代谢疾病智能诊疗的研究，子课题1负责人：代谢性疾病分子机制解析及元件开发，国家重点研发计划子课题，2019YFA090451，398万元，2020.01-2024.1
2.心理应激促进脂肪组织生成尿酸及致高尿酸血症机，2018年国家自然基金面上项目负责人，81870616，经费57万元，负责人，2019-01 2022-12
3.LAMTOR1调节的足细胞自噬在糖尿病肾病发病中的作，2016年国家自然基金面上项目负责人，81670737，经费58万元，2017-01 2020-12
4.代谢性炎症对慢性肾脏病进展和肾纤维化的促进作用及其机制（973计划研究专项课题，2012CB517700，经费50.4万元，学术骨干，2012-2016）
5.Role of PGC-1α-mediated mitochondrial ROS pathway in nephropathy in type 2 diabetes，欧洲糖尿病研究基金会项目负责人，经费Euro 10万， 2011－2013
6.PGC-1α调控的线粒体ROS通路在2型糖尿病肾病早期发病中的作用，2010年国家自然基金面上项目负责人，81070649，经费32万元，2011－2013
7.色素上皮源因子在氧化应激导致的胰岛β细胞损伤中作用机制及意，2008年国家自然基金面上项目负责人，30871204，经费33万元，2009－2011文章发表Publications (*Corresponding author, #Co-first Author)
1. Liu F, Chen S, Hu Z, Chen J, Jiang L, Qu S*, Chen H*. Musculoskeletal ultrasound features-based scoring system can evaluate the severity of gout and asymptomatic hyperuricaemia. Ther Adv Musculoskel Dis. 2021, 2021 May 12;13:1759720X211006985. doi: 10.1177/1759720X211006985. eCollection 2021.（IF: 5.3）
2. Chen X, Wu M, Liang N, Lu J, Qu S*, Chen H*. Thyroid Hormone-Regulated Expression of Period2 Promotes Liver Urate Production. Front. Cell Dev. Biol. 2021 Apr 1;9:636802. doi: 10.3389/fcell.2021.636802. eCollection 2021. （IF: 6.68）
3. Wu M, Ma Y, Chen X, Liang N, Qu S*, Chen H*. Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency. Dis Model Mech. 2021 Mar 24;14(3): dmm 048041. doi: 10.1242/dmm.048041. （IF: 5.76）
4. Guo K, Pan P, Wu M, Ma Y, Lu J, Chen H*. Hyposialylated angiopoietin-like-4 induces apoptosis of podocytes via β1 Integrin/FAK signaling in diabetic nephropathy. Mol Cell Endocrinol. 2020 Jan 22:110730. doi: 10.1016/j.mce.2020.110730. [Epub ahead of print] （IF: 4.1）
5. Wu M, Liu F, Chen J, Chen L, Wei C, Hu Z, Han Y, Lu J, Jiang L*, Chen H*.Prevalence and factors associated with bone erosion in patients with gout. Arthritis Care Res (Hoboken). 2019 Dec;71(12):1653-1659. doi: 10.1002/acr.23816. [Epub ahead of print] （IF: 4.53）
6. Wu M, Zhang M, Ma Y, Liu F, Chen S, Lu J, Chen H*. Chaetocin attenuates gout in mice through inhibiting HIF-1α and NLRP3 inflammasome-dependent IL-1β secretion in macrophages. Arch Biochem Biophys. 2019, 670, July 30(19): 94-103. doi: 10.1016/j.abb.2019.06.010.（IF: 3.559）
7. Yu H, Zhang M, Ma Y, Lu J, Pan J, Pan P, Chen H*, Jia W*. 5-ALA ameliorates hepatic steatosis through AMPK signaling pathway. J Mol Endocrinol. 2017 Aug;59(2):121-128. （IF: 3.297）
8. Han Y, Zhang M, Lu J, Zhang L, Han J, Zhao F, Chen H*, Bao Y, Jia W*. Hyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes. Sci Rep. 2017 Jun 19;7(1):3802. （IF: 4.122）
9. Guo K, Zhang L, Lu J, Yu H, Wu M, Bao Y, Chen H*, Jia W*. Non-alcoholic fatty liver disease is associated with late but not early atherosclerotic lesions in Chinese inpatients with type 2 diabetes. J Diabetes Complications. 2017 Jan;31(1):80-85. doi: 10.1016/j.jdiacomp.2016.09.008. Epub 2016 Sep 27. （IF: 2.792）
10. Zhang L, Guo K, Lu J, Zhao F, Yu H, Han J, Bao Y, Chen H*, Jia W*. Nonalcoholic Fatty Liver Disease is Associated with Increased Carotid Intima-Media Thickness in Type 1 Diabetic Patients. Sci Rep. 2016 May 26;6:26805. doi: 10.1038/srep26805. （IF: 4.259）
11. Guo K, Zhang L, Zhao F, Lu J, Pan P, Yu H, Bao Y, Chen H*, Jia W*. Prevalence of chronic kidney disease and associated factors in Chinese individuals with type 2 diabetes: Cross-sectional study. J Diabetes Complications. 2016 Jul;30(5):803-10. doi: 10.1016/j.jdiacomp.2016.03.020. Epub 2016 Mar 17 （IF: 2.734）
12. Guo K, Yu H, Lu J, Bao Y, Chen H*, Jia W*. Decreased serum betatrophin levels correlate with improved fasting plasma glucose and insulin secretion capacity after Roux-en-Y gastric bypass in obese Chinese patients with type 2 diabetes: a 1-year follow-up. Surg Obes Relat Dis. 2016 Jan 29. pii: S1550-7289(16)00029-0. doi: 10.1016/j.soard.2016.01.024. [Epub ahead of print] . （IF：4.496）
13. Zhao S, Li T, Li J, Lu Q, Han C, Wang N, Qiu Q, Cao H, Xu X, Chen H*, Zheng Z*. miR-23b-3p induces the cellular metabolic memory of high glucose in diabetic retinopathy through a SIRT1-dependent signaling pathway. Diabetologia, 2016, 59(3), 644-654. （IF: 6.08）
14. Zhao F, Zhang L, Lu J, Guo K, Wu M, Yu H, Zhang M, Bao Y, Chen H*, Jia W*. The Chronic Kidney Disease Epidemiology Collaboration equation improves the detection of hyperfiltration in Chinese diabetic patients. Int J Clin Exp Med, 2015, 8(12):22084-22097. （IF: 1.075）
15. Guo K, Lu J, Kou J, Wu M, Zhang L, Yu H, Zhang M, Bao Y, Chen H*, Jia W*. Increased urinary Smad3 is significantly correlated with glomerular hyperfiltration and a reduced glomerular filtration rate and is a new urinary biomarker for diabetic nephropathy. BMC Nephrology , 2015, 16 (10):159. （IF: 2.289）
16. Guo K, Lu J, Huang Y, Wu M, Zhang L, Yu H, Zhang M, Bao Y, He JC*, Chen H*, Jia W*. Protective Role of PGC-1α in Diabetic Nephropathy Is Associated with the Inhibition of ROS through Mitochondrial Dynamic Remodeling. Plos one. 2015;10(4):e0125176. （IF: 3.057）
17. Guo K, Lu J, Yu H, Zhao F, Pan P, Zhang L, Chen H*, Bao Y, Jia W*. Serum betatrophin concentrations are significantly increased in overweight but not in obese or type 2 diabetic individuals. Obesity (Silver Spring). 2015 ;23(4):793-7. （IF: 3.614）
18. Chen HB, Jia WP. Biomarkers for diabetes prediction, diagnosis and personalized therapy. Chin Med J (Engl). 2012; 125(23):4163-4166. （IF:0.901）
19. Huang Y, Yu H, Lu J, Guo K, Zhang L, Bao Y, Chen H*, Jia W. Oral Supplementation with Cholecalciferol 800 IU Ameliorates Albuminuria in Chinese Type 2 Diabetic Patients with Nephropathy. Plos one. 2012; 7(11):e50510.（IF: 3.73）
20. Chen H, Lu J, Chen X, Yu H, Zhang L, Bao Y, Lu F, Tang J, Gu C, Jia W. Low serum levels of the innate immune component ficolin-3 is associated with insulin resistance and predicts the development of type 2 diabetes. J Mol Cell Biol. 2012 Aug;4(4):256-7.（IF: 7.667）
21. Chen H, Zheng Z, Huang Y, Guo K, Lu J, Zhang L, Yu H, Bao Y, Jia W. A microalbuminuria threshold to predict the risk for the development of diabetic retinopathy in type 2 diabetes mellitus patients. Plos one. 2012; 7(5):e36718. （IF: 3.73）
22. Zheng Z, Chen HB#, Wang H, Ke BL, Zheng BQ, Li Q, Li PY, Su L, Gu Q, Xu X. Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial ROS pathway mediated by PGC-1α. Diabetes. 2010; 59,2315-2325.（IF: 8.889）
23. Chen HB, Zheng Z, Li RX, Lu JX, Bao YQ, Ying XF, Zeng R, Jia WP. Urinary pigment epithelium-derived factor as a marker of diabetic nephropathy. Am J Nephrol. 2010 ;32(1):47-56.（IF: 2.658）
24. Zheng Z, Chen HB#, Zhao H, Liu K, Luo DW, Chen YD, Chen YH, Yang XL, Gu Q, Xu X. Inhibition of JAK2/STAT3-mediated VEGF upregulation under high glucose conditions by PEDF through a mitochondrial ROS pathway in vitro. Invest Ophthalmol Vis Sci. 2010,51(1):64-71.（IF: 3.466）
25. Zheng Z, Chen HB#, Ke GJ, Fan Y, Zou HD, Sun XD, Gu Q, Xu X, Ho PC. The protective effect of perindopril on diabetic retinopathy is associated with decreased VEGF/PEDF ratio: involvement of a mitochondria-ROS pathway. Diabetes. 2009,58(4):954-964.（IF: 8.889）
26. Chen HB, Lu JX, Li Q, Bao YQ, Tang JL, Lu HJ, Xiang KS, Jia WP. The protective effect of the RAS inhibitor on diabetic patients with nephropathy in the context of VEGF suppression. Acta Pharmacol Sin. 2009 Feb;30(2):242-50. （IF: 1.909）
27. Chen H, Jia W, Xu X, Fan Y, Zhan D, Wu H, Xie Z, Zheng Z. Upregulation of PEDF expression by PARP inhibition contributes to the decrease in hyperglycemia-induced apoptosis in HUVECs. Biochem Biophys Res Commun. 2008,369:718-724.（IF: 2.76）
28. Li RX, Chen HB#, Tu K, Zhao SL, Zhou H, Li SJ, Dai J, Li QR, Nie S, Li YX, Jia WP, Zeng R, Wu JR. Localized-statistical quantification of human serum proteome associated with type 2 diabetes. PLoS One. 2008 Sep 16;3(9):e3224. （IF: 4.411）
29. Chen H, Ren A, Hu S, Mo W, Xin X, Jia W. The significance of tumor necrosis factor-alpha in newly diagnosed type 2 diabetic patients by transient intensive insulin treatment. Diabetes Res Clin Pract. 2007,75 : 327-332. （IF: 2.134）
