天然免疫信号传导；宿主与病原体（结核分枝杆菌）相互作用； Innate immune signal transduction; Interaction between Mycobacterium Tuberculosis (MTB) and host immunity

1、美高梅附属上海市肺科医院结核科副主任 Deputy director of department of tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine； 2、59599aa美高梅副教授 Associate Professor, Tongji University School of Medicine

主持国家自然科学基金、上海市科委西医引导项目、上海市卫健委科研项目等多项，参与参与国家“十二五”、“十三五”传染病重大专项课题，参与上海市感染性疾病（结核病）临床医学研究中心，中心副主任。获得“上海市浦江人才计划”，获得中华医学会结核病分会的“中国结核病创新研究青年学者奖”。以第一/通信作者发表国内外结核病论著30余篇，其中sci论文18篇，参编结核病相关著作2部。

承担课题：

1. 上海市感染性疾病（结核病）临床医学研究中心（19MC1910800），中心副主任，经费500万Shanghai Clinical Research Center for Infectious Disease (tuberculosis) ；

2. 上海市肺科医院临床研究项目（FKLY20012），项目负责人，经费：100万Clinical Research Project of Shanghai Pulmonary Hospital；

3. 上海市科委西医引导项目（17411969300），项目负责人，经费：20万，The western medicine guide project of Science and Technology Commission of Shanghai Municipality. ；

4. 上海市浦江人才计划D类，项目负责人，经费：20万，Shanghai Pujiang Program；

5. 国家自然科学基金青年项目（81400006），项目负责人，经费：23万；National Nature Science Foundation of China, Youth Project.

发表论著：

1. Sun Qin*, Wei Sha, Hai-Peng Liu, Peng Wang, Zhi-Bin Liu, Wen-Wen Sun, He-Ping Xiao. Genetic Polymorphisms in Antioxidant Enzymes Modulate the Susceptibility of Idiosyncratic Antituberculous Drug-Induced Liver Injury and Treatment Outcomes in Patients With Tuberculosis. Pharmacotherapy. 2020,40(1): 4-16；

2. Sun Qin, Shen XN, Wang P, Ma J, Sha W*. Targeting cyclophilin-D by miR-1281 Protects Human Macrophages From Mycobacterium tuberculosis-induced Programmed Necrosis and Apoptosis. Aging (Albany NY), 2019, 11 (24), 12661-12673；

3. Ma Jun, Chen Xiaoli, Sun Qin*. microRNA-579 upregulation mediates death of human macrophages with mycobacterium tuberculosis infection. Biochem Biophy Res Co. 2019, 518(2): 219-22.；

4. Gu Ye ; Wu CY ; Yu Fanyou, Gui Xuwei ; Ma Jun; Sun Qin*; Sha Wei*. Application of endobronchial ultrasonography using a guide sheath and electromagnetic navigation bronchoscopy in the diagnosis of atypical bacteriologically-negative pulmonary tuberculosis. Ann Transl Med. 2019, 7(20): 567；

5. Sun Wenwen, Lou Hai, Cao Jie, Wang Peng, Sha Wei, Sun Qin*. LncRNA MEG3 control Mycobacterium Tuberculosis infection via controlled MiR-145-5p expression and modulation of macrophages proliferation. Microb Pathog. 2020, 149:104550；

6. Liping Yan, Qin Sun, Zhibin Liu, Min Wu, Li Liang, Qing Zhang. A microporous roust La(III)-organic framework for cyanosilylation reactions and treatment effect on tuberculosis by activating the PI3K-AKT signaling pathway in immune cells. Arabian Journal of Chemistry. 2020, 13: 5890-99.；

7. Qin Sun, Xiaona Shen, Jun Ma, Hai Lou, Qing Zhang. Activation of Nrf2 signaling by oltipraz inhibits death of human macrophages with mycobacterium tuberculosis infection. Biochem Biophy Res Co. 2020, 531(3): 312-319.；

8. Liping Yan, Qin Sun, Zhibin Liu, Min Wu, Yanping Ge, Qing Zhang. A new porous Co(II)-coordination polymer for the chemical fixation of CO(2)and treatment effect against tuberculosis by reducing thepckAexpression in Mycobacterium tuberculosis. Appl Organomet Chem. 2020, e5908；

9. 孙勤，刘轾彬，沙巍. UGT1A1和CYP2E1基因多态性与一线抗结核药物所致肝损伤易感性研究. 中国防痨杂志，2017，39（10）：1073-1080；

10. 孙勤，肖和平. 抗结核药物所致肝损伤分子遗传机制的探讨< 专题笔谈>. 中华结核和呼吸杂志，2018，41（1）：10-13；

11. 孙勤，王鹏，沙巍，肖和平. NOS2基因多态性与抗结核药物所致肝损伤易感性的相关性研究. 中华传染病杂志，2018，36（1）：12-17