2016年硕士毕业于上海交通大学美高梅,2021年博士毕业于华中科技大学同济美高梅,毕业后进入东方医院内镜中心,从事消化内镜检查和内镜下治疗相关工作,目前为消化内镜中心主治医师,美高梅高等研究院副研究员。主要的研究方向有1、消化内镜诊断与治疗。2、消化道肿瘤发生及进展机制。3、代谢性肝病发生及进展机制。主持国家自然科学基金青年基金1项、美高梅“中央高校基本科研业务费”1项,在研总课题经费42万,以第一参与人参与国家自然科学基金面上项目1项,发表论文14篇,其中SCI论文12篇。近3年以第一作者发表SCI基础论著8篇,其中中科院1区1篇,中科院2区4篇。
主持科研项目:
1.国家自然科学基金青年基金,82203341,TRIM8通过泛素-蛋白酶体系统降解ECHS1促进胃癌血管生成的作用机制研究,30.00万元,项目起止年月:2023年01月至2025年12月。主持。
2.美高梅“中央高校基本科研业务费”, 22120240371,巨噬细胞糖酵解与NASH进展,12.00万元,项目起止年月:2024年4月至2026年3月。主持。
参与科研项目:
国家自然科学基金面上项目,8237112370,磷酸丝氨酸氨基转移酶1(PSAT1)通过调控PFKP蛋白稳定性促进糖酵解及结直肠癌进展的作用机制研究,46.00万元,项目起止年月:2024年01月至2027年12月。第一参与人。
主要发表文章:
1.He L, Feng A, Guo H, et al. LRG1 mediated by ATF3 promotes growth and angiogenesis of gastric cancer by regulating the SRC/STAT3/VEGFA pathway. Gastric Cancer. 2022 May;25(3):527-541.
2.He L, Guo Z, Wang W, et al. FUT2 inhibits the EMT and metastasis of colorectal cancer by increasing LRP1 fucosylation. Cell Communication and Signaling. 2023 Mar 27;21(1):63.
3.He L, Huang C, Wang H, Y et al. Galanin ameliorates liver inflammation and fibrosis in mice by activating AMPK/ACC signaling and modifying macrophage inflammatory phenotype. Frontiers in Immunology. 2023 Apr 26;14:1161676.
4.He L, Wang W, Shi H, et al. THBS4/integrin α2 axis mediates BM-MSCs to promote angiogenesis in gastric cancer associated with chronic Helicobacter pylori infection. Aging (Albany NY). 2021 Aug 14;13(15):19375-19396.
5.He L, Li Z, Zhou D, et al. Galanin receptor 2 mediates antifibrogenic effects of galanin on hepatic stellate cells. Exp Ther Med. 2016 Nov;12(5):3375-3380.
6.Feng A, He L, Jiang J, et al. Homeobox A7 promotes esophageal squamous cell carcinoma progression through C-C motif chemokine ligand 2-mediated tumor-associated macrophage recruitment. Cancer Science. 2023 Aug;114(8):3270-3286.
7.Feng A, He L, Chen T, Xu M. A novel cuproptosis-related lncRNA nomogram to improve the prognosis prediction of gastric cancer. Frontiers in Oncology. 2022 Aug 29;12:957966.
8.Wan D, He L, Guo C, et al. m6A-related lncRNAs predict prognosis and indicate cell cycle in gastric cancer. Frontiers in Genetics. 2023 Jun 20;14:1140218.
9.Chen T, Ailijiang S, He L, Lian J, Xu M. No-touch endoscopic full-thickness resection technique matches the surgical concept as far as possible. Endoscopy. 2024 Jan;56(1):81-82.
10.Zheng K, Sha N, Hou G, Leng Z, Zhao Q, Zhang L, He L, Xu M, Jiang Y, Chen T. IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia. Nature Communications. 2023 Sep 30;14(1):6117.
11.Lian J, Wang G, Li S, Chen T, He L, Xu A, Xu M. Endoscopic Submucosal Dissection for Large Duodenal Laterally Spreading Lesions is Feasible: A Multi-Center Retrospective Study. Surg Laparosc Endosc Percutan Tech. 2023 Feb 1;33(1):45-49.