肿瘤营养感应的基础和转化研究（Fundamental and Translational Research on Nutrient Sensing of Cancer）
姜丛，59599aa美高梅特聘研究员，美高梅附属第十人民医院双聘PI，硕士和博士生导师，入选上海市海外高层次人才引进计划等项目。博士毕业于华东师范大学生命医学研究所，随后于海军军医大学附属长征医院、美国哈佛大学美高梅从事博士后研究项目。主要研究方向为肿瘤营养感应的基础和转化研究。运用CRISPR-Cas9的全基因组筛选、生物化学、细胞生物学、结构生物学、肿瘤生物学的手段，分析肿瘤内部的营养感应，揭示肿瘤恶性进展过程中营养感应的时空变化规律，开发新的靶向策略。主要研究分为以下三个方向：1）肿瘤内mTORC1依赖的营养感应机制和功能研究；2）肿瘤内mTORC1非依赖的营养感应机制和功能研究; 3) 肿瘤微环境中，基质细胞的营养感应与肿瘤恶性进展。
英文：
Dr. Cong Jiang is a distinguished researcher appointed at Tongji University School of Medicine and serves as a dual-appointed Principal Investigator at Tongji University Affiliated Tenth People’s Hospital. With expertise as a mentor for both master’s and doctoral students, she has been recognized through inclusion in the prestigious Shanghai Overseas High-Level Talent Introduction Program, among other notable projects.
She earned her Ph.D. from the Institute of Life Sciences and Medicine at East China Normal University. Following this, she pursued postdoctoral research at the Affiliated Changzheng Hospital of Naval Medical University and Harvard Medical School in the United States. Her primary research thrust revolves around the fundamental and translational aspects of tumor nutrient sensing. Employing a multidisciplinary approach encompassing CRISPR-Cas9-based whole-genome screening, biochemistry, cell biology, structural biology, and tumor biology techniques. Her lab investigates the intricate landscape of nutrient sensing within tumors and delves into unraveling the spatiotemporal dynamics of nutrient sensing during the progression of malignancy and contributes to the development of novel targeting strategies. Dr. Jiang’s research is stratified into three primary directions: (1) Exploring the mechanisms and functionalities of nutrient sensing reliant on mTORC1 within tumors, (2) Investigating nutrient sensing mechanisms and functionalities independent of mTORC1 within tumors, and (3) Examining nutrient sensing dynamics of stromal cells within the tumor microenvironment and their implications in malignant progression.
代表性文章：
Cong Jiang#，Jing Liu#, Shaohui He#, Wei Xu#, Runzhi Huang, Weijuan Pan, Xiaolong Li, Xiaoming Dai1, Jianping Guo, Tao Zhang, Hiroyuki Inuzuka, Ping Wang, John M. Asara, Jianru Xiao，Wenyi Wei1；PRMT1 senses methionine availability to govern mTORC1 activity via arginine methylation of NPRL2，Cell Metabolism, 2023
Cong Jiang#; Xiaoming Dai; Shaohui He; Hongfei Zhou; Lan Fang; Jianping Guo; Songlei Liu;Tao Zhang; Weijuan Pan; Haihong Yu; Tianmin Fu; Dali Li; Hiroyuki Inuzuka; Ping Wang; Jianru Xiao; Wenyi Wei ; Ring domains are essential for GATOR2-dependent mTORC1 activation, Molecular Cell, 2023, 83(1): 74-89.e9
Xiaoming Dai#; Cong Jiang#; Qiwei Jiang; Lan Fang; Haihong Yu; Jinhe Guo; Peiqiang Yan; Fangtao Chi; Tao Zhang; Hiroyuki Inuzuka; John M. Asara; Ping Wang; Jianping Guo; Wenyi Wei; AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1activation, Nature Metabolism, 2023
Deng, Lu#; Jiang, Cong#; Chen, Lei#; Jin, Jiali; Wei, Jie; Zhao, Linlin; Chen, Minghui; Pan,Weijuan; Xu, Yan; Chu, Hongshang; Wang, Xinbo; Ge, Xin; Li, Dali; Liao, Lujian; Liu, Mingyao; Li,Li; Wang, Ping ; The Ubiquitination of RagA GTPase by RNF152 Negatively Regulates mTORC1 Activation, MOLECULAR CELL, 2015, 5(58): 804-818
R.Li#; J.Wei#; C.Jiang#; D.Liu; L.Deng; K.Zhang; P.Wang ; Akt SUMOylation Regulates Cell Proliferation and Tumorigenesis, Cancer Research, 2013, 73(18): 5742-5753
S Li#; C Jiang#; J Pan; X Wang; J Jin; L Zhao; W Pan; G Liao; X Cai; X Li; J Xiao; J Jiang;P Wang ; Regulation of c-Myc protein stability by proteasome activator REGγ, Cell Death &Differentiation, 2014, 22(6): 1000-1011
Dang F#, Jiang C#, Zhang T, Inuzuka H, Wei W. PCAF and SIRT1 modulate ßTrCP1 protein stability in an acetylation-dependent manner. J Genet Genomics. 2021 07 20; 48(7):652-655
Tao Zhang, Daichao Xu,Jianping Liu, Min Wang, Li-Juan Duan, Min Liu, Huyan Meng, Yuan Zhuang, Huibing Wang, Yingnan Wang, Mingming Lv, Zhengyi Zhang, Jia Hu, Linyu Shi, Rui Guo, Xingxing Xie, Hui Liu, Emily Erickson, Yaru Wang, Wenyu Yu1, Fabin Dang, Dongxian Guan,Cong Jiang, Xiaoming Dai1, Hiroyuki Inuzuka, Peiqiang Yan, Jingchao Wang, Mrigya Babuta, Gewei Lian, Zhenbo Tu, Ji Miao,Gyongy Szabo, Guo-Hua Fong, Antoine E Karnoub, Yu-Ru Lee, Lifeng Pan, William G. Kaelin, Jr., Junying Yuan and Wenyi Wei Oxygen-sensitive Prolyl Hydroxylation of RIPK1 Suppresses Its Activation, Nature Cell Biology, 2023,
Tao Zhang, Daichao Xu, Elijah Trefts, Mingming Lv, Hiroyuki Inuzuka, Guobin Song, Min Liu, Jianlin Lu, Jianping Liu, Chen Chu, Min Wang, Huibing Wang, Huyan Meng, Hui Liu, Yuan Zhuang, Xingxing Xie, Fabin Dang, Dongxian Guan, Yuqin Men, Shuwen Jiang, Cong Jiang, Xiaoming Dai1 , Jing Liu, Zhen Wang, Peiqiang Yan, Jingchao Wang, Zhenbo Tu, Mrigya Babuta, Emily Erickson, Alissandra L. Hillis, Christian C. Dibble, John M. Asara, Gyongy Szabo, Piotr Sicinski, Ji Miao, Yu-Ru Lee, Lifeng Pan16, Reuben J. Shaw, Junying Yuan, and Wenyi Wei，Metabolic Orchestration of Cell Death by AMPK-Mediated Phosphorylation of RIPK1,Science,2023
