1.利用人源iPSC分化的神经元和胶质细胞研究AD/PD的遗传突变基因的发病机制
2.利用空间转录组技术研究AD/PD的分子调控网络
3.利用人源化小鼠以及双光子/三光子技术研究移植干细胞的在体功能
4.利用干细胞药物筛选平台研究AD/PD潜在的治疗手段
代表性论文:
(1) Bing Zhu#; Yan Liu#; Spring Hwang; Kailey Archuleta; Huijie Huang; Alex Campos; Rabi Murad;Juan Piña-Crespo; Huaxi Xu; Timothy Y. Huang ; Trem2 deletion enhances tau dispersion andpathology through microglia exosomes, Molecular Neurodegeneration, 2022, 17(1)
(2) Bing Zhu#; LuLin Jiang#; Timothy Huang; Yingjun Zhao; Tongfei Liu; Yongwang Zhong;Xiaoguang Li; Alexandre Campos; Kenneth Pomeroy; Eliezer Masliah; Dongxian Zhang; Huaxi Xu ; ER associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity, NATURE COMMUNICATIONS, 2017, 8(1472)
(3) Tongfei Liu#; Bing Zhu#; Yan Liu#; Xiaoming Zhang#; Jun Yin; Xiaoguang Li; LuLin Jiang; Andrew P. Hodges; Sara Brin Rosenthal; Lisa Zhou; Joel Yancey; Amanda McQuade; Mathew BlurtonJones; Rudolph E. Tanzi; Timothy Y. Huang; Huaxi Xu ; Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE, Journal of experimental medicine, 2020, 217(12)
(4) Lu-Lin Jiang; Bing Zhu#; Yingjun Zhao#; Xiaoguang Li#; Tongfei Liu; Juan Pina-Crespo; Lisa Zhou; Wenxi Xu; Maria J. Rodriguez; Haiyang Yu; Don W. Cleveland; John Ravits; Sandrine Da Cruz;Tao Long; Dongxian Zhang; Timothy Y. Huang; Huaxi Xu ; Membralin deficiency dysregulates astrocytic glutamate homeostasis, leading to ALS-like impairment, The Journal of Clinical Investigation, 2019, 129(8): 3103-3120
