结核性肉芽肿形成的机制探讨及对策研究 Study on the mechanism and countermeasures of tuberculous granuloma formation

结核分枝杆菌新型毒力因子研究 Study on novel virulence factors of Mycobacterium Tuberculosis

中华医学会结核病学分会科学研究专委会委员Member of the Scientific Research Committee of the Tuberculosis Branch of the Chinese Medical Association

中华医学会结核病学分会基础学组常务秘书Executive secretary of the Basic Science Group of the Tuberculosis Branch of the Chinese Medical Association

《结核病与肺部健康杂志》编委Editorial board member of the Journal of Tuberculosis and Lung Health

长期聚焦结核分枝杆菌致病机制研究。基于小鼠和斑马鱼肉芽肿模型，整合多组学分析手段，鉴定出多个在结核性肉芽肿形成中发挥关键调控作用的通路及分子，有望开发具有自主知识产权的结核病诊断新方法及治疗新对策。目前主要利用CRISPR全基因组筛选策略，研究结核分枝杆菌全新未知的毒力因子。主持承担了“十三五”国家传染病防治重大专项子课题，国家自然科学基金面上项目两项，国家自然科学基金青年基金，中央高校专项基金，上海市医学引导项目，上海市自然科学基金等多个国家级或省部级项目。作为第一或通讯作者，在Cell Discovery、Emerging Microbes & Infections、Cellular Signalling等学术杂志发表论文10余篇。申请发明专利10项，其中6项获得授权。参编专著5部。多次在国内外结核病学术会议上进行报告交流。

Dr. Hua Yang focuses on the pathogenesis of Mycobacterium tuberculosis. Based on mouse and zebrafish granuloma models, integrated with multi-omics analysis methods, her team has identified several pathways and molecules that play key regulatory roles in the formation of tuberculosis granulomas, which are expected to develop new diagnostic methods and treatments for tuberculosis with independent intellectual property. Recently, her team uses genome-wide CRISPR screening strategy to study novel virulence factors of Mycobacterium tuberculosis. She was supported by the Chinese National Key Project for Infectious Disease, National Natural Science Foundation of China, Science and Technology Commission of Shanghai Municipality and so on. As first or corresponding author, she has published more than 10 papers on academic journals, such as Cell Discovery, Emerging Microbes & Infections, Cellular Signalling and so on.

Selected publications:

1.Yang H#, Wang F#, Guo XY#, Liu F#, Wu X, Zhao M, Ma M, Liu H, Qin L, Wang L, Tang T, Sha W, Wang Y, Chen J, Huang X, Wang J, Peng C, Zheng R, Tang F, Zhang L, Wu C, Oehlers SH, Song Z, She J, Feng H, Xie X, Ge BX*. Interception of host fatty acid metabolism by mycobacteria under hypoxia to suppress anti-TB immunity. Cell Discov. 2021, 7(1): 90.

2.Ying R, Huang X, Gao Y, Wang J, Liu Y, Sha W*, Yang H*. In vitro Synergism of Six Antituberculosis Agents Against Drug-Resistant Mycobacterium tuberculosis Isolated from Retreatment Tuberculosis Patients. Infect Drug Resist. 2021, 14: 3729-3736.

3.Yang H#, Sha W, Liu ZH, Tang TQ, Liu HP, Qin LH, Cui ZL, Chen JX, Liu F, Zheng RJ, Huang XC, Wang J, Feng YH, Ge BX*. Lysine acetylation of DosR regulates the hypoxia response of Mycobacterium tuberculosis. Emerging Microbes & Infections. 2018, 7(1): 34.

4.Yang H#，Liu H#，Chen H，Mo H，Chen J，Huang X，Zheng R，Liu Z，Feng Y，Liu F，Ge B*. G protein-coupled receptor160 regulates mycobacteria entry into macrophages by activating ERK. Cell Signal. 2016, 28(9): 1145~1151.

5.Yang H#，Sha W#，Song P，Liu Z，Qin L，Huang X，Lu J，Wang J，Duthie MS，Xiao H*，Hu Z*. Screening and identification of immunoactive peptide mimotopes for the enhanced serodiagnosis of tuberculosis. Appl Microbiol Biotechnol. 2016, 100(5): 2279-2287.