卢毅，59599aa美高梅特聘研究员，美高梅附属第十人民医院双聘PI，硕士和博士生导师，入选上海市海外高层次人才引进计划、上海市卫生健康委员会青年人才计划。现主持国家自然科学基金委、上海市卫健委、上海市科委等项目。博士毕业于浙江大学美高梅，随后于浙江大学美高梅、美国加州大学伯克利分校分子细胞生物学系从事博士后研究工作。主要研究方向为生物大分子相分离与基因转录调控和肿瘤发生。综合运用分子细胞生物学、生物化学、肿瘤生物学等手段，结合临床组织样本及病理资料的分析，研究：1）相分离在基因转录调控中的作用；2）相分离凝集体形成和解离的动态调控；3）相分离在肿瘤发生中的功能。
代表性文章：
1. Yi Lu*, Tiantian Wu*, Orit Gutman, Huasong Lu, Qiang Zhou, Yoav I. Henis, Kunxin Luo. Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression. Nature Cell Biology 2020; 22:453-464. (Highlighted in News & Views by Nature Cell Biology; Recommended by F1000)
2. Yi Lu*, Shanshan Xie*, Wen Zhang*, Cheng Zhang, Cheng Gao, Yuqi Cai, Qiang Sun, Zhangqi Xu, Min Xiao, Yanjun Xu, Xiao Huang, Wei Liu, Fudi Wang, Yibin Kang, Tianhua Zhou. Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis. Cell Research 2017; 27:1422-1440. (Cover Article)
3. Yi Lu, Qingwei Zhu, Douglas M. Fox, Carol Gao, Sarah A. Stanley, Kunxin Luo. SARS-CoV-2 downregulates ACE2 through lysosomal degradation. Molecular Biology of the Cell 2022; 33:ar147.
4. Yi Lu, Chunmei Chang. Phase separation in regulation of autophagy. Frontiers in Cell and Developmental Biology 2022; 10:910640.
5. Cheng Zhang*, Wen Zhang*, Yi Lu*, Xiaoyi Yan, Xiumin Yan, Xueliang Zhu, Wei Liu, Yuehong Yang, Tianhua Zhou. NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1. Cell Research 2016; 26:239-253.
6. Sijie Feng, Yinlong Song, Minhong Shen, Shanshan Xie, Wenjing Li, Yi Lu, Yuehong Yang, Guangshuo Ou, Jun Zhou, Fudi Wang, Wei Liu, Xiaoyi Yan, Xin Liang, Tianhua Zhou. Microtubule-binding protein FOR20 promotes microtubule depolymerization and cell migration. Cell Discovery 2017; 3:17032.
*Co-first author
