【研究方向介绍】
主要以胃肠道为研究体系，聚焦Hippo等信号通路调控胃肠道肿瘤发生的功能与机制，专注于从微环境角度揭示肿瘤增殖及治疗抵抗的病理机制，并研发靶向干预策略。迄今共发表研究论文20余篇，其中10篇以（共同）第一或通讯作者身份发表在J Clin Invest (2022), Cell Res (2022), Cancer Res (2021), J Exp Med (2020) 和Proc Natl Acad Sci USA (2018/2017)等国际知名学术期刊，研究成果被F1000Prime, Science Signaling及Cell Research等点评推荐，受邀为中国抗癌协会官方期刊Cancer Biol Med和Chin J Cell Biol撰写综述。并已获授权发明专利9项。
【主持科研项目】
1．基金委优秀青年科学基金，200万（2023-2025）
2．国家自然科学基金面上项目，58万（2021-2024）
3．国家自然科学基金青年基金，24万（2020-2022），已结题
4. 上海市自然基金原创探索计划，50万（2023-2026）
5. 上海市青年科技启明星计划，40万（2022-2025）
6. 上海市浦江人才计划，30万（2019-2021），已结题
7. 遗传国家重点实验室开放课题，30万（2021-2024）
8. 上海市第十人民医院攀登拔尖人才，40万（2021-2023）
【近五年代表性论文】
Liwei An*#, Zhifa Cao*, Pingping Nie, Hui Zhang, Zhenzhu Tong, Fan Chen, Yang Tang, Yi Han, Wenjia Wang, Zhangting Zhao, Qingya Zhao, Yuqin Yang, Yuanzhi Xu, Gemin Fang, Lei Shi, Huixiong Xu#, Haiqing Ma#, Shi Jiao#, Zhaocai Zhou#. Combinatorial targeting of Hippo-STRIPAK and PARP elicits synthetic lethality in gastrointestinal cancers. J Clin Invest, 2022, 132(9): e155468. IF=19.7
Liwei An*, Pingping Nie*, Min Chen*, Yang Tang, Hui Zhang, Jingmin Guan, Zhifa Cao, Chun Hou, Wenjia Wang, Yun Zhao, Huixiong Xu#, Shi Jiao#, Zhaocai Zhou#. MST4 Kinase Suppress Gastric Tumorigenesis by Limiting YAP Activation via a Non-canonical Pathway. J Exp Med, 2020, 217 (6):e20191817. IF=17.6
Liwei An, Chao Dong, Junshi Li, Jie Chen, Jinsong Yuan, Jun Huang, Kui Ming Chan, Chenghan Yu, Michael S.Y. Huen. RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair. Proc. Natl. Acad. Sci. U.S.A., 2018, 115 (35) E8286-E8295. IF=12.8
Liwei An*, Yiyang Jiang *, Howin H.W. Ng, Ellen P.S. Man, Jie Chen, Ui-Soon Khoo, Qingguo Gong, Michael S.Y. Huen. Dual-utility NLS drives RNF169-dependent DNA Damage Responses. Proc. Natl. Acad. Sci. U.S.A., 2017; 114(4): E2872-2881. (Recommended by F1000Prime; Highlighted in Science Signaling – NLS protects DNA damage protein). IF=12.8
Xiaoqing Lu*, Liwei An*, Guangjian Fan*, Lijuan Zang*, Weiyi Huang, Junjian Li, Jun Liu, Weiyu Ge, Yuwei Huang, Jingxuan Xv, Shaoqian Du, Yuan Cao, Tianhao Zhou, Huijing Yin, Li Yu, Shi Jiao, Hongxia Wang. EGFR Signaling Promotes Nuclear Translocation of Plasma Membrane Protein TSPAN8 to Enhance Tumor Progression via STAT3-mediated Transcription. Cell Res, 2022, 32(4):359-374. (Research Highlight by Cell Research). IF=46.3
Yan Meng*, Qiudong Zhao*, Liwei An*, Shi Jiao, Rong Li, Yan Sang, Jianping Liao, Pingping Nie, Fuping Wen, Junyi Ju, Zhaocai Zhou#, Lixin Wei#. A TNFR2-HnRNPK Axis Promotes Primary Liver Cancer Development via Activation of YAP Signaling in Hepatic Progenitor Cells. Cancer Res, 2021, 81:3036–3050. IF=13.3
Liwei An*, Ruixian Yu*, Yi Han, Zhaocai Zhou. Decoding the intercellular communication network during tumorigenesis, Cancer Biol Med, 2021, 2095-3941 (受邀综述). IF=4.3
CAO Zhifa, TANG Yang, NIE pingping, HAN Yi, ZHOU Zhaocai#, AN Liwei#. Roles of STRIPAK complex in tumorigenesis. Chin J Cell Biol, 2022, 10.1844/cjcb.2022.04.0074. (受邀综述)
Lichao Zhang*, Xiaoqing Lu*, Yuanzhi Xu*, Xiaoqin La, Jinmiao Tian, Aiping Li, Hanqing Li, Changxin Wu, Yanfeng Xi, Guisheng Song, Zhaocai Zhou, Wenqi Bai#, Liwei An#, Zhuoyu Li#. Tumor-associated macrophages confer colorectal cancer 5-fluorouracil resistance by promoting MRP1 membrane translocation via an intercellular CXCL17/CXCL22–CCR4–ATF6–GRP78 axis. Cell Death Dis 14, 582 (2023). https://doi.org/10.1038/s41419-023-06108-0. IF=9.0
Zhifa Cao*, Liwei An*, Yi Han, Shi Jiao#, Zhaocai Zhou#;. The Hippo signaling pathway in gastric cancer. Acta Biochim Biophys Sin (Shanghai). 2023. doi: 10.3724/abbs.2023038. Epub ahead of print. PMID: 36924251. (受邀综述). IF=3.6
