59599aa美高梅“分子病原生物学”课题组长、美高梅脑与脊髓临床研究中心冠名研究员、中国动物学会寄生虫专业委员会理事、中国微生物学会人兽共患病病原学专业委员会委员、《Decoding Infection & Transmission》副主编、《中国寄生虫学与寄生虫病杂志》常务编委、《中国病原生物学杂志》编委、Front Cell Infect Microbiol编辑、Front Cell Dev Biol客座编辑、F1000 associate faculty member等
热带病是当今全球公共卫生的主要问题之一，例如疟疾与艾滋病、结核病一起并列全球三大传染病，每年导致2亿多人感染，其中死亡人数近百万，给广大发展中国家带来严重的经济和社会负担。真核病原微生物感染宿主后需要经过一系列与宿主的适应性相互作用过程，如建立感染、致病、生殖、产生抗药性等。这些过程皆依赖于病原体对各类功能基因阶段性表达的严格调控，从而执行不同的生物学功能。张青锋教授团队以功能基因组和表观遗传整合研究为核心，以危害最大的疟原虫为研究模型，围绕疟原虫与宿主相互作用，聚焦抗原变异、致病与传播等关键互作过程中相关基因表达调控机制的共性问题，致力于阐明疟原虫与人体宿主互作的表观遗传调控网络，获得了一系列原创性成果。近年来，张青锋教授团队在Nature、Cell Host & Microbe、Nucleic Acids Research、PNAS、Translational Research、iScience、mBio等高影响力学术期刊上发表了多项研究成果，例如：率先发现首个控制脑型疟疾的蛋白质因子PfRNaseII及其作用机制、首次明确了疟原虫高级染色质结构形成的分子调控网络、率先揭示了控制疟原虫配子生殖的多重表观遗传调控网络，等等。这些工作不仅揭示了疟疾感染、致病与传播等过程的关键机制，而且为新型抗疟药研制及我国消除疟疾工作提供了重要理论依据。
主持项目：
国家自然科学基金重点项目两项（2017.01-2021.12；2023.01-2027.12）
国家重点研发计划子课题一项（2018.5-2023.4）
国家自然科学基金国际合作项目一项（2014.1－2017.12）
国家自然科学基金面上项目3项（2013.01-2016.12；2017.01-2020.12；2020.01-2023.12）
代表性论文（*通讯作者）：
Liu M#, Han Z#, Zhi Y, Ruan Y, Cao G, Wang G, Xu X, Mu J, Kang J, Dai F, Wen X, Zhang Q*, Li F*. Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer. Transl Res. 2022 Oct 9:S1931-5244(22)00206-7. doi: 10.1016/j.trsl.2022.09.004.
Xu X#, Wang Y#, Wang C, Guo G, Yu X, Dai Y, Liu Y, Wei G, He X, Jin G, Zhang Z, Guan Q, Pain A, Wang S, Zhang W, Young ND, Gasser RB, McManus DP*, Cao J*, Zhou Q*, Zhang Q*. Chromosome-level genome assembly defines female-biased genes associated with sex determination and differentiation in the human blood fluke Schistosoma japonicum. Mol Ecol Resour. 2022 Jul 17. doi: 10.1111/1755-0998.13689.
Shang X#, Wang C#, Fan Y#, Guo G#, Wang F, Zhao Y, Sheng F, Tang J, He X, Yu X, Zhang M, Zhu G, Yin S, Mu J, Culleton R, Cao J*, Jiang M*, Zhang Q*. Genome-wide landscape of ApiAP2 transcription factors reveals a heterochromatin-associated regulatory network during Plasmodium falciparum blood-stage development. Nucleic Acids Res. 2022 Apr 8;50(6):3413-3431. doi: 10.1093/nar/gkac176.
Liu M#, Guo G#, Qian P#, Mu J#, Lu B, He X, Fan Y, Shang X, Yang G, Shen S, Liu W, Wang L, Gu L, Mu Q, Yu X, Zhao Y, Culleton R, Cao J, Jiang L, Wellems TE*, Yuan J*, Jiang C*, Zhang Q*. 5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2110713119. doi: 10.1073/pnas.2110713119.
Shang X#, Shen S#*, Tang J#, He X, Zhao Y, Wang C, He X, Guo G, Liu M, Wang L, Zhu Q, Yang G, Jiang C, Zhang M, Yu X, Han J, Culleton R, Jiang L, Cao J*, Gu L*, Zhang Q*. A cascade of transcriptional repression determines sexual commitment and development in Plasmodium falciparum. Nucleic Acids Res. 2021 Sep 20;49(16):9264-9279. doi: 10.1093/nar/gkab683.
Lu B#, Liu M#, Gu L#, Li Y#, Shen S, Guo G, Wang F, He X, Zhao Y, Shang X, Wang L, Yang G, Zhu Q, Cao J, Jiang C, Culleton R, Wei G*, Zhang Q*. The Architectural Factor HMGB1 Is Involved in Genome Organization in the Human Malaria Parasite Plasmodium falciparum. mBio. 2021 Apr 27;12(2):e00148-21. doi: 10.1128/mBio.00148-21.
Yang M#, Shang X#, Zhou Y, Wang C, Wei G, Tang J, Zhang M, Liu Y, Cao J*, Zhang Q*. Full-Length Transcriptome Analysis of Plasmodium falciparum by Single-Molecule Long-Read Sequencing. Front Cell Infect Microbiol. 2021 Feb 23;11:631545. doi: 10.3389/fcimb.2021.631545.
Zhao Y#, Wang F#, Wang C, Zhang X, Jiang C, Ding F, Shen L*, Zhang Q*. Optimization of CRISPR/Cas System for Improving Genome Editing Efficiency in Plasmodium falciparum. Front Microbiol. 2021 Jan 8;11:625862. doi: 10.3389/fmicb.2020.625862.
Fan Y#, Shen S#, Wei G#, Tang J#, Zhao Y, Wang F, He X, Guo G, Shang X, Yu X, Ma Z, He X, Liu M, Zhu Q, Le Z, Wei G, Cao J, Jiang C*, Zhang Q*. Rrp6 Regulates Heterochromatic Gene Silencing via ncRNA RUF6 Decay in Malaria Parasites. mBio. 2020 Jun 2;11(3):e01110-20. doi: 10.1128/mBio.01110-20.
Yin S#*, Fan Y#, He X, Wei G, Wen Y, Zhao Y, Shi M, Wei J, Chen H, Han J, Jiang L*, Zhang Q*. The cryptic unstable transcripts are associated with developmentally regulated gene expression in blood-stage Plasmodium falciparum. RNA Biol. 2020 Jun;17(6):828-842. doi: 10.1080/15476286.2020.1732032. Epub 2020 Feb 27.
Liu M#, Lu B#, Fan Y, He X, Shen S, Jiang C*, Zhang Q*. TRIBE Uncovers the Role of Dis3 in Shaping the Dynamic Transcriptome in Malaria Parasites. Front Cell Dev Biol. 2019 Nov 1;7:264. doi: 10.3389/fcell.2019.00264.
Droll D#, Wei G#, Guo G, Fan Y, Baumgarten S, Zhou Y, Xiao Y, Scherf A*, Zhang Q*. Disruption of the RNA exosome reveals the hidden face of the malaria parasite transcriptome. RNA Biol. 2018;15(9):1206-1214. doi: 10.1080/15476286.2018.1517014.
Zhang Q*, Siegel TN, Martins RM, Wang F, Cao J, Gao Q, Cheng X, Jiang L, Hon CC, Scheidig-Benatar C, Sakamoto H, Turner L, Jensen AT, Claes A, Guizetti J, Malmquist NA, Scherf A*. Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria. Nature. 2014 Sep 18;513(7518):431-5. doi: 10.1038/nature13468.
