1.神经退行性疾病尤其是阿尔茨海默病机制与干预研究

2.精神障碍的神经学机制与干预研究

3.干细胞对脑神经疾病脑卒中、AD的移植治疗研究

1.59599aa美高梅教授、博士硕士研究生导师，课题组长;

2.美高梅附属同济医院特聘研究员

3.59599aa美高梅人体解剖与组织胚胎学系副主任（主持工作）

4.上海市解剖学会理事；中国解剖学会科普委员会副主任委员; 中国神经科学学会会员

5.国家自然科学基金初审专家；教育部博士学位论文盲审专家

6.国际杂志 Brain Reseach Bulletin; Brain Structure and Function, Neuroscience 等杂志的特约审稿人

课题组代表性论文

1.Li-Fen Liu, Yu-Tong Liu, Dan-Dan Wu, Jie Cheng, Na-Na Li, Ya-Ni Zheng, Liang Huang, Qiong-Lan Yuan* Inhibiting 5-hydroxytryptamine receptor 3 alleviates pathological changes of a mouse model of Alzheimer’s disease. Neural Regen Res. 2023;18(9):2019-2028.

2.Dan-Dan Wu, Jie Cheng, Ya-Ni Zheng, Yu-Tong Liu, Shuang-Xin Hou, Li-Fen Liu, Liang Huang and Qiong-Lan Yuan*. Neuroplastin 65 deficiency reduces amyloid plaque formation and cognitive deficits in an Alzheimer’s disease mouse model. Front. Cell. Neurosci. 2023, 17:1129773.

3.Shen-Jun Wen, Xi-min Zheng, Li-Fen Liu, Na-na Li, Hai-an Mao, Liang Huang, Qiong-lan Yuan*. Effects of primary microglia and astrocytes on neuroal stem cells in in vitro and in vivo models of ischemic stroke. Neural Regeneration Research, 2021, 16（9）：1677-1685.

4.Lifen Liu, Yutong Liu, Nana Li, Runzhi Huang, Ximing Zheng, Liang Huang, Shuangxin Hou, Qionglan Yuan*. Multiple inflammatory profiles of microglia and altered neuroimages in APP/PS1 transgenic AD mice. Brain Research Bulletin 2020,156:86–104

5.Huanhuan Li, Yutong Liu, Xiaoqing Gao, Lifen Liu, Siyiti Amuti, Dandan Wu, Fen Jiang, Liang Huang, Geying Wang, Jiujiang Zeng, Bin Ma, Qionglan Yuan*. Neuroplastin 65 modulates anxiety- and depression-like behavior likely through adult hippocampal neurogenesis and central 5-HT activity. The FEBS Journal 2019, 286: 3401–3415

6.Xiaoqing Gaoa,b, Dandan Wua, Ling Doua, Haibo Zhanga, Liang Huanga, Jiaqi Zenga, Yiiie Zhanga, ChaoxianYangb, Huanhuan Lia, Lifen Liua, Bin Mac, QionglanYuan* Protective Effects of Mesenchymal Stem Cells Overexpressing Extracellular Regulating Kinase 1/2 Against Stroke in Rats. Brain Research Bulletin, 2019, 149: 42–5

7.Li H, Zeng J, Huang L, Wu D, Liu L,Liu Y, Yuan Q*. Microarray Analysis of Gene Expression Changes in Neuroplastin 65-Knockout Mice: Implications for Abnormal Cognition and Emotional Disorders. Neurosci Bull. 2018, 34(5):779-788

8.Yuhui Hui, Qin Zhan, Haibo Zhang, Xiaoqing Liu, Liang Huang, Huanhuan Li and Qionglan Yuan*. Increased Susceptibility to Ischemic Brain Injury in Neuroplastin 65-Deficient Mice Likely via Glutamate Excitotoxicity. Front Cell Neurosci. 2017 ;11:110. eCollection 2017.