1. 欧洲自然科学院院士
2. 美国神经科学学会“女性神经科学家理事会”、“职业发展理事会”理事
3. 戈登会议分子细胞神经生物学会议副主席（2014）/主席（2016）
4. 中国干细胞再生医学专业委员会常务委员
5. 中国干细胞产业联盟理事会专家委员会委员
6. 中国整形美容协会干细胞研究与应用分会理事会常务理事
7. Cells期刊编委
1. Full member, the European Academy of Natural Sciences (EANS);
2. Member, Committee on Women in Neuroscience, Society for Neuroscience (SfN-WIN);
Member, Professional Development Committe, Society for Neuroscience (SfN-PDC)
3. Vice Chair, Gordon Research Conference (GRC), Molecular & Cellular Neurobiology (2014);
Chair, Gordon Research Conference (GRC), Molecular & Cellular Neurobiology (2016)
4. Member, Standing Committee of China Stem Cell Regenerative Medicine Professional Committee
5. Member, Standing Committee of Expert Committee of China Stem Cell Industry Alliance Council
6. Member, Standing Committee of the Council of Stem Cell Research and Application Branch of China Plastic and Aesthetic Association
7. Member, Editorial Board of Cells journal
孙毅博士在神经干细胞生物学、神经修复及自闭症谱系病Rett综合征（RTT）领域成果卓著，不仅对MECP2基因在神经干细胞中的功能，以及通过人源多能干细胞建立疾病模型方面成就不断，并且在全球首次成功利用基因编辑技术建立了表型酷似人类疾病的非人灵长类RTT模型，发表于Cell Stem Cell（2014），Cell（2017）；首次通过单细胞测序发现室管膜静息态成体神经干细胞，发表于Cell（2015）；结合生物材料促进中枢神经系统再生，揭示了中枢神经系统修复的底层逻辑，即抑制损伤区域炎性微环境，激活内源性神经干细胞产生新生神经元，继而形成“中继站”网络整合入受损神经环路，通过神经可塑性开辟新的神经信号传递通路进而恢复功能，相关研究成果发表于PNAS（2015a/b, 2018）。
近年来她的工作逐步延伸，聚焦于运用系统生物学方法探究“循环免疫-中枢神经系统免疫-神经元功能”间的交叉互作。她建立了高效分类器可用于识别免疫细胞亚类精准描述个体免疫态，进而建立了基于免疫态的细胞治疗疗效评估体系。成功研发出自体年轻化普罗米修斯细胞用于抗衰老及治疗包括“渐冻症”（ALS）在内的神经退行性疾病。
她先后发表120余篇SCI论文，包括Cell、Nature、Science正刊10篇，总影响因子超过2,000，H指数（H-index）为67，被引频次共计2万余次。曾获美国斯隆研究奖（Alfred P. Sloan Research Fellow）、贝克曼青年研究者奖（Beckman Young Investigator Award）、白厅基金会研究奖 （Whitehall Foundation Research Award）、克林根斯坦神经生物学研究奖（Klingenstine Neuroscience Research Award）、上海市科学技术-国际合作奖、上海市科学技术奖等奖项。曾担任神经生物学会（SfN）“女性神经科学家理事会”（WIN）理事、SfN“职业发展理事会”（PDC）理事。
Dr. Yi Eve Sun has made continuous contributions in the field of neural stem cell biology, neural repair, and autism spectrum disorders including Rett syndrome (RTT), by studying the function of MECP2 gene in neural stem cells and the establishment of disease-in-dish models through human pluripotent stem cells. She and her collaborators are the first to use gene-editing to establish non-human primate RTT models, which showed striking phenotype, resembling the human disease, and her work was published in Cell Stem Cell (2014), and Cell (2017). She also discovered that endogenous CD133 positive ependymal quiescent adult neural stem cells are the seeds for neural regeneration through single-cell sequencing, which was published in Cell (2015). She postulated the fundamental underlying logic for Neural Repair, i.e., “under non-inflammatory and neural trophic environment, endogenous neural stem cells will be activated to generate new neurons, which subsequently form new neural networks to be integrated into broken neural circuitries, and through plasticity, to re-establish or resume neural transmission and function”, which was published in PNAS (2015a/b, 2018).
In recent years, her work has taken systems biology-based approaches to study cross interactions amongst “circulation immunity-CNS immunity-Neuronal function”. She initiated single cell transcriptome-based immune typing of individuals with different age, gender, and pathological conditions, aiming at targeting CNS diseases via the periphery, including reprograming autologous cells. She successfully invented a new reprogramming method to convert autologous dermal fibroblasts into rejuvenated mesenchymal stem cells, called “Prometheus Cells”, which start to demonstrate great therapeutic values in treating ALS (a neural degenerative disease) and reverse aging. Prometheus cells not only put “a break” on disease progression, but also improved function, which has never been reported.
She has published 120+ papers in top journals, including 10 articles in Cell, Nature, Science. Total impact factors of her publications are more than 2,000, with a total of more than 20,000 citations. Her H index (H-index) is 67. She has won a number of awards, including the Alfred P. Sloan Research Fellow, the Beckman Young Investigator Award, the Whitehall Foundation Research Award, the Klingenstine Neurobiology Research Award, the Shanghai Science and Technology Award for International Collaboration, and the Shanghai Science and Technology Award. She has served on many scientific boards and committees, including the Committee on Women in Neuroscience (C-WIN) within the Society for Neuroscience (SFN).
