心血管疾病是全球主要的死亡原因，其发生、发展中免疫调控机制异常复杂。我们实验室致力于研究免疫细胞在心血管疾病发生和发展中的作用及其调控机制，特别是特异性T细胞亚群的分化和功能，旨在揭示其在心血管疾病中的调控机制，并探索潜在的免疫干预疗法。

Cardiovascular diseases are a leading cause of global mortality, with complex immune regulation mechanisms. Our lab focuses on understanding the role of immune cells in the onset and progression of cardiovascular diseases and their regulatory mechanisms. Specifically, we investigate the differentiation and function of specific T cell subsets, aiming to elucidate their regulatory roles in cardiovascular disease development and explore potential immunotherapeutic interventions.

1.中国免疫学会心血管免疫学分会委员

2.上海细胞生物学会理事

3. Frontier in Immunology杂志 Review Editor for T Cell Biology

英文：

1.Committee Member of the Cardiovascular Immunology Branch, Chinese Society of Immunology

2. Committee Member of the Shanghai Society for Cell Biology

3. Review Editor for T Cell Biology of the journal Frontier in Immunology

王海坤研究员长期致力于T细胞稳态和辅助性T细胞分化机制的研究，已发表SCI论文50余篇（其中29篇影响因子>10），其中以第一或通讯作者在Nature Immunology、PNAS、Nature Communications、Cell Discovery、Cellular & Molecular Immunology、PLoS Biol.等国际主流学术杂志上发表学术论文；目前，拥有授权专利3项（包括1项国际专利）；注册1项临床试验。代表性研究论文如下：

1. Deng X, Wang L, Zhai Y, Liu Q, Du F, Zhang Y, Zhao W, Wu T, Tao Y, Deng J, Cao Y, Hao P, Ren J, Shen Y, Yu Z, Zheng Y, Zhang H, Wang H. RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell death. Cell Mol Immunol. 2024 Jan;21(1):80-90. doi: 10.1038/s41423-023-01113-x.

2. Gu W, Zhang J, Li Q, Zhang Y, Lin X, Wu B, Yin Q, Sun J, Lu Y, Sun X, Jia C, Li C, Zhang Y, Wang M, Yin X, Wang S, Xu J, Wang R, Zhu S, Cheng S, Chen S, Liu L, Zhu L, Yan C, Yi C, Li X, Lian Q, Lin G, Ling Z, Ma L, Zhou M, Xiao K, Wei H, Hu R*, Zhou W*, Ye L*, Wang H*, Li J*, Sun B*. The TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation. Cell Discov. 2023 Aug 1;9(1):82. doi: 10.1038/s41421-023-00561-z. PMID: 37528081; PMCID: PMC10394018.

3. Ao YQ, Jiang JH, Gao J, Wang H*, Ding J*. Recent thymic emigrants as the bridge between thymoma and autoimmune diseases. Biochim Biophys Acta Rev Cancer. 2022 May;1877(3):188730. doi: 10.1016/j.bbcan.2022.188730.

4. Zang J, Yin Y, Xu S, Qiao W, Liu Q, Lavillette D, Zhang C, Wang H*, Huang Z*. Neutralizing Potency of Prototype and Omicron RBD mRNA Vaccines Against Omicron Variant. Front Immunol. 2022 Jun 30;13:908478. doi: 10.3389/fimmu.2022.908478. PMID: 35844601; PMCID: PMC9280631.

5. Gao S, Jiang J, Jin C, Gao J, Xiong D, Yang P, Cui S, Yang W, Leng Q, Dong J, Chen G, Liu J, Wang L, Ke A, Wang H*, Ding J*. Interleukin-8 as a candidate for thymoma identification and recurrence surveillance. Nat Commun. 2020;11(1):4881. doi: 10.1038/s41467-020-18697-x. PMID: 32985506 （第一完成单位）.

6. Cao Y, Wang X, Yang Q, Deng H, Liu Y, Zhou P, Xu H, Chen D, Feng D, Zhang H, Wang H*, Zhou J. Critical Role of Intestinal Microbiota in ATF3-Mediated Gut Immune Homeostasis. J Immunol. 2020 Aug 1;205(3):842-852. doi: 10.4049/jimmunol.1901000.

7. Wang, M., Huang, Y., Gu, W., Wang, H. Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice. J Vis Exp. 2020;(160). doi: 10.3791/60523.

8. Liang H, Tang J, Liu Z, Liu Y, Xu Y, Hao P, Yin Z, Zhong J, Ye L, Jin X, Wang H. ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice. Nat Commun. 2019;10(1):3859. doi: 10.1038/ s41467-019-11754-0.

9. Ren J, Han L, Tang J, Liu Q, Deng X, Liu Q, Hao P, Feng X, Li B, Hu H, Wang H. Foxp1 is critical for the maintenance of regulatory T-cell homeostasis and suppressive function. PLoS Biol. 2019; doi.org/10.1371/journal.pbio.3000270.

10. He L, Gu W, Wang M, Chang X, Sun X, ZhangY, Lin X, Yan C, FanW, Su P, Wang Y, Yi C, Lin G, Li L, Lu J, Wang H* and Sun B*. ECM1 promotes differentiation of follicular helper T cells and antibody production. Proc Natl Acad Sci USA. 2018; 115(34):8621-8626.

11. Wang H, Geng J, Wen X, Bi E, Kossenkov A, Wolf A, Tas J, Choi Y, Takata H, Day T, Chang LY, Sprout S, Becker E, Willen J, Tian L, Wang X, Xiao C, Jiang P, Crotty S, Victora G, Showe L, Tucker H, Erikson J and Hu H. The transcription factor Foxp1 is a critical negative regulator of T follicular helper cell differentiation. Nature Immunol. 2014; 15 (7): 667-675.

英文：

Prof. wang has long been dedicated to studying T cell homeostasis and the mechanisms of helper T cell differentiation, with over 50 SCI papers published (29 of which have an impact factor >10). Representative publications are as follows:

1. Deng X, Wang L, Zhai Y, Liu Q, Du F, Zhang Y, Zhao W, Wu T, Tao Y, Deng J, Cao Y, Hao P, Ren J, Shen Y, Yu Z, Zheng Y, Zhang H, Wang H. RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell death. Cell Mol Immunol. 2024 Jan;21(1):80-90. doi: 10.1038/s41423-023-01113-x.

2. Gu W, Zhang J, Li Q, Zhang Y, Lin X, Wu B, Yin Q, Sun J, Lu Y, Sun X, Jia C, Li C, Zhang Y, Wang M, Yin X, Wang S, Xu J, Wang R, Zhu S, Cheng S, Chen S, Liu L, Zhu L, Yan C, Yi C, Li X, Lian Q, Lin G, Ling Z, Ma L, Zhou M, Xiao K, Wei H, Hu R*, Zhou W*, Ye L*, Wang H*, Li J*, Sun B*. The TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation. Cell Discov. 2023 Aug 1;9(1):82. doi: 10.1038/s41421-023-00561-z. PMID: 37528081; PMCID: PMC10394018.

3. Ao YQ, Jiang JH, Gao J, Wang H*, Ding J*. Recent thymic emigrants as the bridge between thymoma and autoimmune diseases. Biochim Biophys Acta Rev Cancer. 2022 May;1877(3):188730. doi: 10.1016/j.bbcan.2022.188730.

4. Zang J, Yin Y, Xu S, Qiao W, Liu Q, Lavillette D, Zhang C, Wang H*, Huang Z*. Neutralizing Potency of Prototype and Omicron RBD mRNA Vaccines Against Omicron Variant. Front Immunol. 2022 Jun 30;13:908478. doi: 10.3389/fimmu.2022.908478. PMID: 35844601; PMCID: PMC9280631.

5. Gao S, Jiang J, Jin C, Gao J, Xiong D, Yang P, Cui S, Yang W, Leng Q, Dong J, Chen G, Liu J, Wang L, Ke A, Wang H*, Ding J*. Interleukin-8 as a candidate for thymoma identification and recurrence surveillance. Nat Commun. 2020;11(1):4881. doi: 10.1038/s41467-020-18697-x. PMID: 32985506 （第一完成单位）.

6. Cao Y, Wang X, Yang Q, Deng H, Liu Y, Zhou P, Xu H, Chen D, Feng D, Zhang H, Wang H*, Zhou J. Critical Role of Intestinal Microbiota in ATF3-Mediated Gut Immune Homeostasis. J Immunol. 2020 Aug 1;205(3):842-852. doi: 10.4049/jimmunol.1901000.

7. Wang, M., Huang, Y., Gu, W., Wang, H. Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice. J Vis Exp. 2020;(160). doi: 10.3791/60523.

8. Liang H, Tang J, Liu Z, Liu Y, Xu Y, Hao P, Yin Z, Zhong J, Ye L, Jin X, Wang H. ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice. Nat Commun. 2019;10(1):3859. doi: 10.1038/ s41467-019-11754-0.

9. Ren J, Han L, Tang J, Liu Q, Deng X, Liu Q, Hao P, Feng X, Li B, Hu H, Wang H. Foxp1 is critical for the maintenance of regulatory T-cell homeostasis and suppressive function. PLoS Biol. 2019; doi.org/10.1371/journal.pbio.3000270.

10. He L, Gu W, Wang M, Chang X, Sun X, ZhangY, Lin X, Yan C, FanW, Su P, Wang Y, Yi C, Lin G, Li L, Lu J, Wang H* and Sun B*. ECM1 promotes differentiation of follicular helper T cells and antibody production. Proc Natl Acad Sci USA. 2018; 115(34):8621-8626.

11. Wang H, Geng J, Wen X, Bi E, Kossenkov A, Wolf A, Tas J, Choi Y, Takata H, Day T, Chang LY, Sprout S, Becker E, Willen J, Tian L, Wang X, Xiao C, Jiang P, Crotty S, Victora G, Showe L, Tucker H, Erikson J and Hu H. The transcription factor Foxp1 is a critical negative regulator of T follicular helper cell differentiation. Nature Immunol. 2014; 15 (7): 667-675.