1.国家自然科学基金函评专家、生命学部专家评审组成员 ;
2.中国细胞生物学学会,常务理事;
3.上海市生物化学与分子生物学学会,常务理事;
4.中国病理生理学会第一届蛋白质修饰与疾病专业委员会,委员;
5.中国抗癌协会第一届微环境专业委员会,副主任委员;
6.中国医药生物技术转化医学分会第二届委员会,常务委员;
7.中国细胞生物学学会肿瘤细胞生物学分会,秘书长;
8.上海市细胞生物学学会,副理事长;
9.上海市免疫学会肿瘤免疫专业委员会,委员;
10.Editorial Board Member:World Journal of Biological Chemistry
个人履历:
1. 2017.03-至今 59599aa美高梅 副院长;
2. 2015.02-至今 美高梅生命科学与技术学院/59599aa美高梅 教授及博士生导师;
3. 2015.02- 2017.03 上海市第十人民医院科研处 处长、上海市第十人民医院中心实验室 主任;
4. 2008.07- 2015.02 华东师范大学生科院生命医学研究所教授及博士生导师、生命医学系系主任, 生化与分子生物学学科主任、上海市调控生物学重点实验室 PI ;
5. 2006.10-2008.06 美国耶鲁大学药理学系 博士后;
6. 2006.01-2006.10 美国康涅狄格大学健康中心 博士后;
7. 2003.01-2005.12 美国明尼苏达大学药理学系 博士后;
8. 1997.09-2002.07 中科院上海生化与细胞生物研究所 博士;
9. 1992.09-1997.07 复旦大学生命科学学院 学士 ;
主要奖励:
1.2019年 长江学者奖励计划特聘教授;
2.2018年 科技部创新人才推进计划中青年科技创新领军人才;
3.2018年 上海领军人才;
4.2017年 上海卫生系统优秀学科带头人;
5.2016年 国家基金委杰出青年基金获得者;
6.2013年 上海市‘青年科技启明星’追踪人才计划;
7.2012年 国家基金委优秀青年基金获得者 ;
8.2011年 上海市‘曙光学者’人才计划;
9.2010年 教育部‘新世纪人才’计划;
10.2009年 上海市‘青年科技启明星’人才计划;
11.2006年 AHA Postdoctoral fellowship;
12.2000年 中科院地奥奖学金;
13.1999年 中科院伟华奖学金 ;
主要基金课题:
1.2020YFA0803201组织器官生长和尺寸控制的信号转导基础209万元
2.2021/01-2025/12 科技部国家重点研发计划发育编程及其代谢调节重点专项,课题骨干;
3.31920103007泛素化修饰调控胱氨酸转运介导铁死亡的机制263万元
4.2020/01-2024/12 国家自然科学基金国际(地区)合作与交流项目;
5.31830053泛素化修饰调控mTORC1细胞代谢通路Ragulator的机制及功能研究 281万元 国家自然科学基金重点项目2019/01-2023/12;
6.81625019 肿瘤微环境与泛素化调控 350万元 2017/01- 2021/12 国家自然科学基金委杰青项目 ;
7.91519322 胚胎干细胞分化及细胞重编程过程中组蛋白H2A去泛素化机制的研究 90万元 2016/1-2016/12 国家自然科学基金重点项目 ;
8.16JC1404500 代谢平衡的泛素化调控 50万元 2016/7-2019/6 上海市科委 ;
9.91440104 PHLPP2作为ceRNA调控肿瘤发生的机制和功能研究 80万元 2015/1-2017/12 国家自然科学基金重大项目 ;
10.31222037 细胞迁移与信号传导 100万元 2013/01-2015/12 国家自然科学基金优秀青年科学基金项目;
11.2012CB910404 GPCR配体的高通量筛选及信号转导机理研究 270万元;
12.2012/1-2016/12 科技部“973”计划项目 ;
13.31171338 PIP5K1C参与中性粒细胞极性及运动的信号传导机制研究 60万元 2012/1-2015/12 国家自然科学基金面上项目
(1)Xinbo Wang(#), Yueqing Chen(#), Xudong Wang(#), Hongling Tian, Yanjin Wang, Jiali Jin, Zezhi Shan, Yu e Liu, Zhenyu Cai, Xinyuan Tong, Yi Luan, Xiao Tan, Bing Luan, Xin Ge, Hongbin Ji, Xuejun Jiang, Ping Wang(*). Stem cell factor SOX2 confers ferroptosis resistance in lung cancer via upregulation of SLC7A11. Cancer Research, 2021.8.21 online.
(2)Wen Zhang(#), Jiali Jin(#), Yanjin Wang(#), Lan Fang, Liu Min, Xinbo Wang, Lin Ding, Linjun Weng, Tan Xiao, Tianhua Zhou & Ping Wang(*). PD-L1 regulates genomic stability via interaction with Cohesin-SA1 in the Nucleus. Signal Transduction and Targeted Therapy, 2021.2.25,6:81.
(3)Jiawen Zhang (#), Yunfei Chen (#), Xianfei Chen, Wen Zhang , Linlin Zhao, Linjun Weng, Hongling Tian, Zhiqiang Wu, Xiao Tan, Xin Ge, Ping Wang(*), Lan Fang(*). Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovarian cancer. Cell Death & Differentiation, 2021 Jan;28(1):139-155.
(4)Zhiqiang Wu(#), Linjun Weng(#), Tengbo Zhang(#), Hongling Tian, Lan Fang, Hongqi Teng, Wen Zhang, Jing Gao, Yun Hao, Yaxu Li, Hu Zhou & Ping Wang(*). Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis. Cell Research, 2019.2; 29(2):136-150.
(5)Xinbo Wang(#); Jiali Jin(#); Fangning Wan(#); Linlin Zhao(#); Hongshang Chu; Cong Chen; Guanghong Liao; Jian Liu; Yue Yu; Hongqi Teng; Lan Fang; Cong Jiang; Weijuan Pan; Xin Xie; Jia Li; Xiaolin Lu; Xuejun Jiang; Xin Ge(*); Dingwei Ye(*); Ping Wang(*), AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness. Developmental Cell, 2019.1, (48): 1~16.
(6)Fang Lan(#); Teng Hongqi(#); Wang Yilin(#); Liao Guanghong(#); Weng Linjun; Li Yaxu; Wang Xinbo; Jin Jiali; Jiao Chenchen; Chen Lei; Peng Xiaoping; Chen Jiayu; Yang Yongzhi; Fang Houqin; Han Dongyan; Li Cheng; Jin Xueling; Zhang Shihao; Liu Zhongchen; Liu Min; Wei Qing; Liao Lujian; Ge Xin; Zhao Bin; Zhou Dawang; Qin Huan-Long; Zhou Jun; Wang Ping(*). SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis. Cancer Cell, 2018.7.9, 34(1): 103.
(7)Deng Lu(#); Chen Lei(#); Zhao Linlin; Xu Yan; Peng Xiaoping; Wang Xinbo; Ding Lin; Jin Jiali; Teng Hongqi; Wang Yanming; Pan Weijuan; Yu Fei; Liao Lujian; Li Li; Ge Xin; Wang Ping(*). Ubiquitination of Rheb governs growth factor-induced mTORC1 activation. Cell Research, 2019.2,29(2):136-150.
(8)Zhao, Linlin(#); Wang, Xinbo(#); Yu, Yue; Deng, Lu; Chen, Lei; Peng, Xiaoping; Jiao, Chenchen; Gao, Guoli; Tan, Xiao; Pan, Weijuan; Ge, Xin(*); Wang, Ping(*), OTUB1 suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR. Journal of Biological Chemistry, 2018.3.30, 293(13): 4883~1892.
(9)Chen, Yunfei(#),Wang, Lufan(#),Jin, Jiali,Luan, Yi,Chen, Cong,Li, Yu,Chu, Hongshang,Wang, Xinbo,Liao, Guanghong,Yu, Yue,Teng, Hongqi,Wang, Yanming,Pan, Weijuan,Fang, Lan,Liao, Lujian,Jiang, Zhengfan,Ge, Xin,Li, Bin,Wang, Ping(*). p38 inhibition provides anti-DNA virus immunity by regulation of USP21 phosphorylation and STING activation. Journal of Experimental Medicine,2017.4,214(4):991~1010.
(10)Liao, Peng(#); Wang, Weichao(#); Li, Yu(#); Wang, Rui(#); Jin, Jiali(#); Pan, Weijuan; Chen, Yunfei; Shen, Mingyue; Wang, Xinbo; Jiang, Dongyang; Pang, Jinjiang; Liu, Mingyao; Lin, Xia; Feng, Xin-Hua; Wang, Ping(*); Ge, Xin(*), Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis. eLife, 2017.3.31, 6.
(11)Wang, W.(#),Liao, P.(#),Shen, M.,Chen, T.,Chen, Y.,Li, Y.,Lin, X.,Ge, X.(*),Wang, P.(*), SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Ser62. ONCOGENE,2016.1.28,35(4):491~500.
(12)Jinxia Sun(#),Yi Luan(#),Dong Xiang,Xiao Tan,Hui Chen,Qi Deng,Jiaojiao Zhang,Minghui Chen,Hongjun Huang,Weichao Wang,Tingting Niu,Wenjie Li,Hu Peng,Shuangxi Li,Lei Li,Wenwen Tang,Xiaotao Li(*),Dianqing Wu(*),Ping Wang(*), The 11S proteasome subunit PSME3 is a positive feedforward regulator of NF-κB and important for host defense against bacterial pathogens. Cell Reports,2016.2.2,14(4):737~749.
(13)Jin, Jiali(#); Liu, Jian(#); Chen, Cong; Liu, Zhenping; Jiang, Cong; Chu, Hongshang; Pan, Weijuan; Wang, Xinbo; Zhang, Lingqiang; Li, Bin; Jiang, Cizhong; Ge, Xin; Xie, Xin(*); Wang, Ping(*), The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog. Nature Communications, 2016.11.25, 7.
(14)Li, S.(#); Jiang, C.(#); Pan, J.; Wang, X.; Jin, J.; Zhao, L.; Pan, W.; Liao, G.; Cai, X.; Li, X.; Xiao, J.(*); Jiang, J.(*); Wang, P.(*), Regulation of c-Myc protein stability by proteasome activator REG gamma. Cell Death and Differentiation, 2015.6, 22(6): 1000~1011.
(15)Lu Deng(#),Cong Jiang(#),Lei Chen(#),Jiali Jin,Jie Wei,Linlin Zhao,Minghui Chen,Weijuan Pan,Yan Xu,Hongshang Chu,Xinbo Wang,Xin Ge,Dali Li,Lujiang Liao,Mingyao Liu,Li Li,Ping Wang(*) , The Ubiquitination of RagA GTPase by RNF152 Negatively Regulates mTORC1 Activation. Molecular Cell,2015.6.4,58(5):804~818.
(16)Jinjin Pan(#),Qi Deng,Cong Jiang,Xinbo Wang,Tingting Niu,Hui Li,Taiqi Chen,Jiali Jin,Weijuan Pan,Xiaopan Cai,Jianru Xiao(*),Ping Wang(*), USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer. Oncogene,2015.7,34(30):3957~3967.
(17)Chen, Yunfei(#),Wang, Lufan(#),Cheng, Xiaomu,Ge, Xin,Wang, Ping(*), An ultrasensitive system for measuring the USPs and OTULIN activity using Nanoluc as a reporter. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014.12.12, 455(3-4):178~183.
(18)Peng Liao(#),Weichao Wang(#),Mingyue Shen,Weijuan Pan,Kai Zhang,Rui Wang,Taiqi Chen,Yihua Chen,Huaqing Chen,Ping Wang(*), A positive feedback loop between EBP2 and c-Myc regulates rDNA transcription, cell proliferation, and tumorigenesis. Cell Death and Disease, 2014.1, 5.
(19)Rong Li(#),Jie Wei(#),Cong Jiang(#),Dongmei Liu,Lu Deng,Kai Zhang,Ping Wang(*), Akt SUMOylation Regulates Cell Proliferation and Tomorigenesis. Cancer Research,2013.9.15,73(18):5742~5753 .
(20)Rui Wang(#),Yan Wang(#),Ning Liu(#),Chunguang Ren(#),Cong Jiang,Kai Zhang,Su Yu,Yunfei Chen,Hui Tang,Qi Deng,Fu Cong,Yingcong Wang,Rong Li,Mingyao Liu,Weijun Pan,Ping Wang(*), FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation. Cell Research,2013.6,23(6):803~819.
(21)Ning Xiao(#),Hui Li(#),Jian Luo(#),Rui Wang,Haiquan Chen,Jiquan Chen(*),Ping Wang(*), Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNF alpha-induced cancer cell migration. Biochemical Journal,2012.2.1,441(3):979~98.
(22)Wenwen Xu(#),Ping Wang(#)(*),Bjoern Petri,Yong Zhang,Wenwen Tang,Le Sun,Holger Kress,Tom Mann,Yan Shi,Paul Kubes,Dianqing Wu(*), Integrin-Induced PIP5K1C Kinase Polarization Regulates Neutrophil Polarization, Directionality and In Vivo Infiltration. Immunity,2010.9.24,33(3):340~350.
(23)Ning Liu(#),Hui Li,Shuangxi Li,Mingyue Shen,Ning Xiao,Yunfei Chen,Yan Wang,Weichao Wang,Rui Wang,Qian Wang,Jianhua Sun,Ping Wang(*), The Fbw7/Human CDC4 Tumor Suppressor Targets Proproliferative Factor KLF5 for Ubiquitination and Degradation through Multiple Phosphodegron Motifs. Journal of Biological Chemistry,2010.6.11,285(24):18858~18867.
授权发明专利:
1.Ub-Nanoluc、Ub-Ub-GS-Nanoluc报告基因系统及其构建和应用,专利号:ZL 201410053262.4
2.一种鉴定YAP甲基化的方法及其应用,专利号:ZL 201810329545.5,