在国际上率先报道了siRNA量子点纳米载体系统，阐明了siRNA高效转染纳米载体结构特征与作用机制；探明了多糖纳米材料靶向作用肿瘤细胞膜脂质层的抗肿瘤作用机理；筛选鉴定了胶质瘤血管抑制作用靶点及作用机制。已在国际权威期刊JACS、ACS nano、Biomacromolecules、Journal Material Chemistry、European Journal of Cancert.等杂志发表SCI科研论文近20篇。论文被他引超过600次，单篇论文他引180余次。其中在JACS, ACS nano，European Journal of Cancer发表的论文被美国癌症研究所重点报道，在ACS nano发表论文被列为当期重点推荐文章，并在该杂志年度总结中作为亮点论文介绍。最近发表在Recent Pat Biotechnol.上论文被列为该研究方向TOP20 排名第一论文。申请发明专利6项，授权2项。
已发表论文：
[1] Qi L*, Shao W, Shi D. JAM-2 siRNA intracellular delivery and real-time imaging by proton-sponge coated quantum dots. J. Mater. Chem. B, 2013, Advance Article. DOI: 10.1039/C2TB00027J. (IF:5.968)
[2] Qi L*, Wu S, Zheng S, Fu H, Cui D. Cell permeable magnetic nanoparticles for siRNA delivery. Biomolecules, 2012, 13(9), 2723-2730. (IF:5.47).
[3] Shao W, Zheng S, Qi L*. Recent patents on nanosensor for tumor biomarker detection. Nano Biomed. Eng. 2011, 3(1):66-72.
[4] Qi L, Zheng S, Lin B. Recent patents on imaging nanoprobes for brain tumor diagnosis and therapy. Recent Pat Biotechnol. 2010 Jun 1;4(2):130-5. (IF:5.2)
[5] Lin, B, Jin, S, Wang, J, Qi L,et.al Meeting report: the 2009 Westlake International Conference on Personalized Medicine,《OMICS》, V0l.13(4), 2009.
[6] Qi L, Gao X. Quantum Dot-Amphipol Nanocomplex for Intracellular Delivery and Real-Time Imaging of siRNA. ACS nano, 2008, 2(7), 1403–1410 (IF: 11).
[7] Yezhelyev M.V., Qi L, O’Regan R.M., Nie S., Gao X. Proton-sponge-coated quantum dots for siRNA delivery and intracellular imaging. J. Am. Chem. Soc. 2008, 130, 9006-9012 (IF:7.9)
[8] Qi L, Gao X. Emerging application of quantum dots for drug delivery and therapy. Expert Opin. Drug Deliv. 2008; 5:263-267 (,IF:4.8).
[9] Qi L, Pal S, Dutta P, Seehra M, Pei M. Morphology controllable nanostructured chitosan matrix and its cytocompatibility. J. Biomed. Mater. Res. A. 2007 Dec. 18 online (IF:2.5).
[10] Qi L*, Xu Z, Chen M. In vitro and in vivo suppression of growth of human hepatoma BEL7402 cells by chitosan nanoparticles. Eur. J. Cancer 2007; 43:184-93 (IF:5.2).
[11] Qi L, Xu Z. In vivo antitumor activity of chitosan nanoparticles. Bioorg. Med. Chem. Lett. 2006, 16, 4243-5 (IF2.6).
[12] Qi L, Xu Z, Li Y, Jiang X, Han X. In vitro effects of chitosan nanoparticles on proliferation of human gastric carcinoma cell line MGC803. World J Gastroenterol. 2005; 11(33): 5136-5141 (IF:3.3).
[13] Qi L, Xu Z, Jiang X, Li Y, Wang M. Cytotoxic activities of chitosan nanoparticles and copper-loaded nanoparticles. Bioorg. Med. Chem. Lett. 2005; 15: 1357-1399 (IF:2.6).
[14] Qi L, Xu Z, Jiang X, Hu C, Zou X. Preparation and antibacterial activity of chitosan nanoparticles, Carbohydr. Res. 2004; 339 (16): 2693-2700 (IF:2.5).
[15] Qi L, Xu Z. Lead sorption from aqueous solutions on chitosan nanoparticles, Colloids Surfaces A: Physicochem Eng Aspects 2004; 251: 183-190 (IF:2.2).
[16] Qi L, Dutta P, Pas S, Seehra M, Pei M. Preparation and characterization of chitosan nanocrystal. NSTI Nanotech 2007, Bio Nano Material & Tissues Syposium, Santa Clara, California, May 20-24, 2007, abstract number 755.
[17] Qi L, Dutta P, Pas S, Seehra M, Pei M. Chitosan nanaocrystals: A potential Biomaterial for tissue engineering application. NSTI Nanotech 2007, Bio Nano Material & Tissues Syposium, Santa Clara, California, May 20-24, 2007, abstract number 770.
[18] Gao X. Qi L. Quantum dot for efficient delivery and real-time imaging of siRNA. ACS 236th National meeting, Aug. 17-21, 2008.
承担课题：
1．国家自然科学基金 批准号:30900345，新型分子影像siRNA纳米载体系统的构建及其在乳腺癌应用基础研究。2010年1月~2012年12月。
2．2009年国家教育部博士点基金-新教师类（20090101120155，MiR-127 和MiR-433在神经胶质瘤发生发展中的功能性研究，2010-01-01~2011-12-31）。
3．教育部留学人员回国启动资金，新型分子影像siRNA纳米载体系统靶向转染脑胶质瘤细胞分子机理研究,2010.12-2012.12 。
专利：
PCT/CN2004/000774 Xu Z，Qi L. Fabrication of chitosan nanoparticles as anticancer agents.
CN200410016440.2 Xu Z，Qi L. Hu C. Xia M. 一类多糖类抗菌纳米材料制备及应用。
CN200410016441.7 Xu Z，Qi L. Hu C. Xia M. 一类多糖类抗癌纳米材料制备及应用。
200910096432.6 亓立峰，靶向识别肿瘤细胞的纳米药物载体材料及其制备和应用。
201110067159.1. 亓立峰，一种检测手足口病病原的纳米探针芯片及其应用方
法。
201210119028.8，亓立峰，一种靶向抑制胶质瘤细胞浸润和转移的方法及其应用。
