主要从事生物信息学与表观遗传学的研究。利用生物信息学策略和分子遗传学技术研究心肌细胞定向分化的表观遗传调节机制和心脏病相关基因的识别；基于生物大数据的复杂疾病的生物标志物识别、分子分型及网络构建。发表论文70余篇，专利5项
科研项目：
1、项目来源：国家自然科学基金面上项目；项目名称：RNA结合蛋白SAMD4靶向FGF2/FGF18维系心肌细胞分化通路的研究；项目负责人。
2、项目来源：国家自然科学基金面上项目；项目名称：ERG1介导Integrinβ1维持大鼠心脏发育信号稳态的研究；项目负责人。
3、项目来源：上海市科委基础领域重点项目；项目名称：microRNA-26b核内调节机制；项目负责人。
4、项目来源：中央高校基本科研业务费重点学科交叉；项目名称：新的先天性致病基因CX45的识别功能研究及诊断芯片研制；项目负责人。
5、项目来源：国家自然科学基金面上项目；项目名称：microRNA-26b在心肌细胞分化中对GATA4和KCNJ2的同步调节机制；项目负责人。
6、项目来源：国家重点基础研究发展计划；项目名称：miRNA和蛋白质修饰在干细胞对称和不对称分裂过程中的作用及机理；项目骨干。
7、项目来源：国家自然科学基金面上项目；项目名称：离子通道药物靶点识别的生物信息融合方法研究；项目负责人。
发表论文：
1. Huang J, Wang L, Shen Y, Zhang S, Zhou Y, Du J, Ma X, Liu Y, Liang D, Shi D,Ma H, Li L*, Zhang Q*, Chen YH*. CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation. Nat Commun. 2022 Jul 30;13(1):4433. doi: 10.1038/s41467-022-31996-9. （通讯作者）
2. Shang M, Hu Y, Cao H, Lin Q, Yi N, Zhang J, Gu Y, Yang Y, He S, Lu M, Peng L*,Li L*. Concordant and Heterogeneity of Single-Cell Transcriptome in Cardiac Development of Human and Mouse. Front Genet. 2022 Jun 27;13:892766.（通讯作者）
3. Luo X, Hu Y, Shen J, Liu X, Wang T, Li L*, Li J*. Integrative analysis of DNA methylation and gene expression reveals key molecular signatures in acute myocardial infarction. Clin Epigenetics. 2022 Mar 27;14(1):46.（通讯作者）
4. Liu C, Cui Z, Yan Y, Wu NL, Li L*, Ying Q*, Peng L*. An optimized proliferation system of embryonic stem cells for generating the rat model with large fragment modification. Biochem Biophys Res Commun. 2021 Sep 24;571:8-13.（通讯作者）
5. Xie D, Xiong K, Su X, Wang G, Ji Q, Zou Q, Wang L, Liu Y, Liang D, Xue J, Wang L, Gao X, Gu X, Liu H, He X, Li L, Yang J, Lu Y, Peng L, Chen YH. Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes. Cell Res. 2021 Sep;31(9):951-964.
6. Liang D, Xue J, Geng L, Zhou L, Lv B, Zeng Q, Xiong K, Zhou H, Xie D, Zhang F, Liu J, Liu Y, Li L, Yang J, Xue Z, Chen YH. Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing. Nat Commun. 2021 Jan 12;12(1):287.
7. Wang D, Liu C, Liu H, Meng Y, Lin F, Gu Y, Wang H, Shang M, Tong C, Sachinidis A, Ying Q, Li L*, Peng L*. ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signaling. Stem Cells. 2021 Apr;39(4):443-457. （通讯作者）
8. Li Z, Meng Y, Liu C, Liu H, Cao W, Tong C, Lu M, Li L*, Peng L*. Kcnh2 mediates FAK/AKT-FOXO3A pathway to attenuate sepsis-induced cardiac dysfunction. Cell Prolif. 2021 Feb;54(2):e12962. （通讯作者）
9. Wu Y, Zhou L, Liu H, Duan R, Zhou H, Zhang F, He X, Lu D, Xiong K, Xiong M, Zhuang J, Liu Y, Li L, Liang D, Chen YH. LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration. Cell Res. 2021 Apr;31(4):450-462.
10. Guo XJ, Qiu XB, Wang J, Guo YH, Yang CX, Li L, Gao RF, Ke ZP, Di RM, Sun YM, Xu YJ, Yang YQ. PRRX1 Loss-of-Function Mutations Underlying Familial Atrial Fibrillation.J Am Heart Assoc. 2021 Dec 7;10(23):e023517.
11. Wang Y, Yi N, Hu Y, Zhou X, Jiang H, Lin Q, Chen R, Liu H, Gu Y, Tong C, Lu M, Zhang J, Zhang B, Peng L*, Li L*. Molecular Signatures and Networks of Cardiomyocyte Differentiation in Humans and Mice. Mol Ther Nucleic Acids. 2020 Sep 4;21:696-711. （通讯作者）
12. Li Z, Yi N, Chen R, Meng Y, Wang Y, Liu H, Cao W, Hu Y, Gu Y, Tong C, Lu M, Li L*, Peng L*. miR-29b-3p protects cardiomyocytes against endotoxin-induced apoptosis and inflammatory response through targeting FOXO3A. Cell Signal. 2020 Oct;74:109716. （通讯作者）
13. Xie D, Geng L, Xiong K, Zhao T, Wang S, Xue J, Wang C, Wang G, Feng Z, Zhou H, Li Y, Li L, Liu Y, Xue Z, Yang J, Ma H, Liang D, Chen YH. Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase. Circ Res. 2020 Jun 5;126(12):1706-1720.
14. Chen R, He J, Wang Y, Guo Y, Zhang J, Peng L, Wang D, Lin Q, Zhang J, Guo Z*,Li L*. Qualitative transcriptional signatures for evaluating the maturity degree of pluripotent stem cell-derived cardiomyocytes. Stem Cell Res Ther. 2019 Mar 29;10(1):113. （通讯作者）
15. Li Z, Zhu H, Liu C, Wang Y, Wang D, Liu H, Cao W, Hu Y, Lin Q, Tong C, Lu M,Sachinidis A, Li L*, Peng L*. GSK-3β inhibition protects the rat heart from thelipopolysaccharide-induced inflammation injury via suppressing FOXO3A activity. J Cell Mol Med. 2019 Nov;23(11):7796-7809. （通讯作者）
16. Wang D, Wang Y, Liu H, Tong C, Ying Q, Sachinidis A, Li L*, Peng L*. Laminin promotes differentiation of rat embryonic stem cells into cardiomyocytes by activating the integrin/FAK/PI3K p85 pathway. J Cell Mol Med. 2019 May;23(5):3629-3640. （通讯作者）
17. Wen-Jing Wang Yu-Wei Wang, Yi Hu, Lin Qin, Rou Chen, Huan Liu, Wen-Ze Cao, Hui-Fang Zhu, Chang Tong, Li Li* and Lu-Ying Peng*.,HDncRNA: a manually constructed database of relationship between heart disease and noncoding RNAs. Database. 2018 Jan 1; doi: 10.1093/database/bay067. （通讯作者）
18. Wang W, Zhang P, Li L, Chen Z, Bai W, Liu G, Zhang L, Jia H, Li L*, Yu Y*, Liao M*. ATD: a comprehensive bioinformatics resource for deciphering the association of autophagy and diseases. 1. Database (Oxford). 2018 Jan 1; doi: 10.1093/database/bay093. （通讯作者）
19. Wang D, Liu C, Wang Y, Wang W, Wang K, Wu X, Li Z, Zhao C, Li L*, Peng L*. Impact of miR-26b on cardiomyocyte differentiation in P19 cells through regulating canonical/non-canonical Wnt signalling. Cell Prolif. 2017 Dec;50(6). （通讯作者）
20. Wang D, Liu C, Li Z, Wang Y, Wang W, Wu X, Wang K, Miao W, Li L*, Peng L*. Regulation of Histone Acetylation on Expression Profiles of Potassium Channels During Cardiomyocyte Differentiation From Mouse Embryonic Stem Cells. J Cell Biochem. 2017 Dec;118(12):4460-4467. doi: 10.1002/jcb.26102. Epub 2017 May 31. （通讯作者）
奖励：
心房颤动发生机制研究，上海市自然科学奖，一等奖，2011年（排名第五）
