成昱,博士,现为美高梅59599aa美高梅/生物医学工程与纳米科学研究院教授,上海自主智能无人系统科学中心副主任。近年来,聚焦微磁力调控,对接人工智能,原创性建立了微磁力超微创治疗新平台,在微磁力学核心理论、多尺度纳米磁力刀核心技术、多类型磁场发生器核心装置等三大方面取得了系列研究成果。近5年,以通讯作者在Advanced Materials、Advanced Science、Angew Chem Int Ed、Small等高质量学术期刊发表科研论文30余篇,专利授权6项,主编英文专著一部,并入选多个相关学会理事和委员。获国自然优秀青年基金、国家重点研发计划“纳米前沿“专项子课题、国自然面上项目(2 项)、上海市基础研究特区计划、上海市教委科研创新计划重大项目等支持。自主研发多种类型(二维细胞治疗、三维小动物治疗和灵长类治疗)的磁场,并首批入驻上海市自主智能无人系统科学中心展馆进行展示。
近三年代表性论文:
1.Cheng Lv#, Yuan Li, Mingzhi Zhang, Yu Cheng*, Da Han*, Weihong Tan*. Sequential Control of Cellular Interactions Using Dynamic DNA Displacement, Nano Letters, 2023, 23(4): 1167-1174.
2.Peng Ning#, Yingna Chen#, Qianwen Bai#, Chang Xu, Cuijun Deng, Qian Cheng*, and Yu Cheng*, Multimodal Imaging-Guided Spatiotemporal Tracking of Photosensitive Stem Cells for Breast Cancer Treatment. ACS Applied Materials & Interfaces, 2022 ,14(6):7551-7564.
3.Cuijun Deng#, Quan Zhou, Meng Zhang, Tian Li, Haotian Chen, Chang Xu, Qishuai Feng, Xin Wang, Feng Yin*, Yu Cheng*, Chengtie Wu*, Bioceramic Scaffolds with Antioxidative Functions for ROS Scavenging and Osteochondral Regeneration. Advanced Science, 2022, 9(12): e2105727.
4.Haotian Chen#, Yingze Li, Yanjin Wang, Peng Ning, Yajing Shen, Xueyan Wei, Qishuai Feng, Yali Liu, Zhenguang Li, Chang Xu, Siyu Huang, Cuijun Deng, Ping Wang, Yu Cheng*, An Engineered Bacteria-Hybrid Microrobot with the Magnetothermal Bioswitch for Remotely Collective Perception and Imaging-Guided Cancer Treatment. ACS Nano, 2022, 16(4): 6118-6133.
5.Chang Xu#, Yali Liu#, Jiayan Li, Peng Ning, Zhong Shi, Wei Zhang, Zhenguang Li, Ruimei Zhou, Yifan Tong, Yingze Li, Cheng Lv, Yajing Shen, Qian Cheng, Bin He, Yu Cheng*, Photomagnetically Powered Spiky Nanomachines with Thermal Control of Viscosity for Enhanced Cancer Mechanotherapy. Advanced Materials, 2023, 35(8): 2204996.
6.Yajing Shen#, Wei Zhang#, Gang Li#, Peng Ning, Li Zhenguang, Chen Haotian, Wei Xueyan, Pan Xin, Qin Yao, He Bin*, Yu Zuoren*, and Yu Cheng*, Adaptive Control of Nanomotor Swarms for Magnetic-Field-Programmed Cancer Cell Destruction. ACS Nano, 2021, 15(12): 20020.
7.Qishuai Feng#, Xianyun Xu#, Chen Wei, Yingze Li, Min Wang, Cheng Lv, JiaoJiao Wu, Yalei Dai, Yu Han, Maciej S. Lesniak, Haiing Fan, Ling Zhang*, Yu Cheng*, The Dynamic Interactions Between Nanoparticles and Macrophages Impact Their Fate in Brain Tumors. Small, 2021, 17(49): e2103600.
8.Gang Yuan#, Cheng Lv#, Jichao Liang, Xinxin Zhong, Yuan Li, Jiacun He, Anjing Zhao, Li Li, Yuanhe Shao, Xiuhua Zhang, Shenfu Wang, Yu Cheng*, Hanping He*, Molecular Engineering of Efficient Singlet Oxygen Generators with Near-Infrared AIE Features for Mitochondrial Targeted Photodynamic Therapy. Advanced Functional Materials, 2021, 31(36): 2104026.
9.Zhenguang Li#, Yingze Li#, Chang Chen, Yu Cheng*, Magnetic-Responsive Hydrogels: From Strategic Design to Biomedical Applications. J Control Release, 2021, 335: 541.
10.Mengwei Chen#, Jiaojiao Wu#, Jingjing Wang, Zuan Ma, Linqun Huang, Gustavo. R. Plaza, Yajing Shen, Chang Xu, Yu Han, Maciej S. Lesniak*, Zhongming Liu*, Yu Cheng*, Remote Control of Mechanical Forces via Mitochondrial-Targeted Magnetic Nanospinners for Efficienct Cancer Treatment, Small, 2020,16(3): e1905424.
11.Jiaojiao Wu#, Peng Ning, Rui Gao, Qishuai Feng, Yajing Shen, Yifan Zhang, Yingze Li, Chang Xu, Yao Qin, Gustavo R Plaza, Qianwen Bai, Xing Fan, Zhenguang Li, Yu Han, Maciej S Lesniak, Haiming Fan, Yu Cheng*, Programmable ROS-Mediated Cancer Therapy via Magneto-Inductions, Advanced Science, 2020, 7, 1902933.
12.Meihua Xie#, Wei Zhang#, Chengying Fan, Chu Wu, Qishuai Feng, Jiaojiao Wu, Yingze Li, Rui Gao, Zhenguang Li, Qigang Wang*, Yu Cheng*, Bin He*, Bioinspired Soft Microrobots with Precise Magneto-Collective Control for Microvascular Thrombolysis, Advanced Materials, 2020, 59(9):3732.
13.Qi Zhang#, Jiaojiao Wu#, Jingjing Wang#, Xia Wang, Chu Wu, Mengwei Chen, Qing Wu, Maciej S. Lesniak, Yongli Mi, Yu Cheng*, Qigang Wang*, A Neutrophils-Inspired Supramolecular Nanogel for Magnetocaloric-Enzymatic Tandem Therapy, Angewandte Chemie International Edition, 2020, 59(9): 3732.
已授权专利情况:
1. 成昱,朱融融。纳米金包覆层状双氢氧化物复合材料及其制备和应用,发明专利,专利号:ZL201510488940.4。
2. 成昱,马赛•莱斯尼亚克。一种应用于肿瘤治疗的低频交变旋转磁场实验装
置,实用新型,专利号: ZL201621216329.2。
3. 成昱,黄立群,哈维尔.贝隆.莫拉莱斯,温晓飞。肿瘤光热治疗实验装置,
实用新型,专利号:201821764833.5。
4. 成昱,邓翠君。一种兼具抗炎和骨-软骨修复功能的生物陶瓷支架及其制备方法与应用,发明专利,专利号:ZL 202011010817.9。
5. 成昱,李珍光。一种多功能抗氧化磁性纳米复合材料及其制备方法,发明专利,专利号:ZL201911135152.1。
6. 成昱,徐畅。一种双模态造影剂、制备方法及其应用,发明专利,专利号:202010736173.5。
7. 成昱,刘雅丽。一种结合永磁与电磁的多模态磁力治疗设备,发明专利,专利号: ZL 202210472214.3。
8. 成昱,覃一飞,刘雅丽。一种双频磁响应纳米治疗平台,实用新型,专利号:ZL 202221955535.0。
主持科研项目情况:
1. 上海市基础研究特区计划,微纳机器人胞内磁力感知与自主免疫调控,2022.12.01-2027.11.30,450万,在研,主持;
2. 2023年度上海市教委科研创新计划自然科学重大项目,2023ZKZD27,癌症精准医疗微纳机器人前沿基础研究,2023.1-2027.12,300万,在研,主持;
3. 国家重点研发计划纳米前沿重点专项,2021YFA1201402,精准电磁调控神经通路的生物物理机制,2021.12-2026.11,410万,在研,主持;
4. 上海市 2021 年度“科技创新行动计划” 优秀学术带头人计划项目,21XD1423900,变频磁力调控介导的肿瘤免疫治疗,2021.07-2024.06,40万,在研,主持;
5. 国家自然科学基金优秀青年科学基金项目,82022039,微磁力抗脑肿瘤研究,2021.01-2023.12,120万,在研,主持;
6. 上海市科委2020年度专项定向项目,20dz1101200,仿生磁感知关键技术研发,2020.11.01-2022.10.31,500万,已结题,主持;
7. 国家自然科学基金面上项目,31870997,磁力调控内涵体/溶酶体逃逸的纳米载药系统抗胶质瘤作用,2019.01-2022.12,59万元,已结题,主持;
8. 美高梅交叉创新重点项目,2019.01-2020.12,40万元,已结题,主持;
9. 上海市教育委员会科研创新计划项目重大项目,201701070007E00038,癌症精准医疗微纳机器人前沿基础研究,2017.07-2022.06, 300万,已结题,主持;
10. 上海市科委国际合作项目,16410724300,靶向线粒体的纳米磁力刀在脑肿瘤治疗中的应用研究,2016.07-2019.06,30万,已结题,主持;
11. 国家自然科学基金面上项目,81571803,神经干细胞介导的纳米磁力刀靶向作用于脑胶质瘤的实验研究,2016.01-2019.12,56万,已结题,主持;
12. 上海市浦江人才,15PJ1407800,干细胞引导纳米磁机械力靶向治疗脑肿瘤,2015. 07-2017-06,20万,已结题,主持;
13. 国家高层次人才计划,2015.04-2018.12,300万,已结题,主持;
14. 美高梅重大项目预研,2015.01-2017.12,30万,已结题,主持。