临床药物分析学、临床代谢物组学与中药化学生物学

Clinical Pharmaceutical Analysis, Clinical Metabolomics, and Chemical Biology of Traditional Chinese Medicine

上海市临床重点专科（临床药学）学科带头人，美高梅附属上海市第四人民医院药剂科主任、药物临床试验机构办公室主任、临床药学教研室负责人。中国优生优育协会临床药学专委会常委；中国医药教育协会药事管理、临床合理用药专委会委员；上海市医院协会临床药事管理专委会委员；上海市医师协会临床合理用药专委会委员；上海市药学会医院药学、药物分析专委会委员；上海市药理学会临床药理、药物代谢、药物临床试验、治疗药物监测研究专委会委员；上海市虹口区医学会药学专委会主任委员；上海市虹口区临床药事质控中心主任。《中国药房》、《中南药学》等专业杂志编委。

The academic leader of the Shanghai Clinical Key Specialty (Clinical Pharmacy), the director of Pharmacy Department and the Office of Drug Clinical Trial Institutions, and the head of the Clinical Pharmacy Teaching and Research Office of the Shanghai Fourth People's Hospital affiliated to Tongji University. Member of the Standing Committee of the Clinical Pharmacy Professional Committee of the China Eugenics and Eugenics Association; Members of the Pharmaceutical Management and Clinical Rational Use Professional Committee of the China Medical Education Association; Member of the Clinical Pharmaceutical Management Professional Committee of Shanghai Hospital Association; Member of the Clinical Rational Drug Use Professional Committee of Shanghai Physicians Association; Members of the Hospital Pharmacy and Pharmaceutical Analysis Professional Committeeof the Shanghai Pharmaceutical Association; Members of the Clinical Pharmacology, the Drug Metabolism, the DrugClinical Trials, and Therapeutic Drug Monitoring Research Professional Committee of the Shanghai Pharmacological Society; Chairman of the Pharmaceutical Professional Committee of ShanghaiHongkou District Medical Association; Director of Shanghai Hongkou District Clinical Pharmaceutical Quality Control Center. Editorial board members of professional magazines such as China Pharmacy and Central South Pharmacy.

研究方向为临床药物分析学、临床代谢物组学与中药化学生物学，主要涉及治疗药物监测与精准药学监护、临床药物代谢与代谢组学研究、药物不良反应监测与药源性疾病研究、中药质量分析与生物活性评价。近五年来主持完成、合作参与国家级、省级及局级科研课题十余项，研究经费300余万元，建立了多维色谱-组合质谱微量分析与宏量制备平台、斑马鱼模式生物多功能筛选平台、个体化药物治疗检测平台、临床治疗药物综合评价平台、中药化学生物学研究技术平台。以第一作者或通讯作者在《Clinical Pharmacology & Therapeutics》、《Frontiers in Pharmacology》、《Arabian Journal of Chemistry》 、《Food Chemistry》、《Journal of Chromatography A》、《Journal of Pharmaceutical and Biomedical Analysis》等国际权威期刊上发表论文20余篇。

The research directions are clinical pharmaceutical analysis, clinical metabolomics, and chemical biology of traditional Chinese medicine, mainly involving therapeutic drug monitoring and precise pharmaceutical care, clinical drug metabolism and metabolomics research, adverse drug reaction monitoring and drug-induced disease research, quality analysis and biological evaluationof traditional Chinese medicine. In the past five years, more than ten scientific research projects have been hosted and participated at national, Shanghai, and bureau level, with a research funding of over 3 million yuan. Many platforms have been established including micro analysis and macro preparation by multi-dimensional chromatography combined mass spectrometry, zebrafish model for multi-biological screening, personalized drug treatment and detection, comprehensive evaluation of clinical therapeutic drug, and chemical biology research technology of traditional Chinese medicine. As the first/corresponding author, it is published over 20 papers in international authoritative journals such as Clinical Pharmacy&Therapeutics, Frontiers in Pharmacy, Arabian Journal of Chemistry, Food Chemistry, Journal of Chromatography A, and Journal of Pharmaceutical and Biomedical Analysis.