长期聚焦抗真菌药物的研究与开发及药物靶点研究。获得2020年上海市“超级博士后”激励资助项目;获得国家自然科学基金青年项目;获得美高梅2021年自主原创基础研究项目重点项目资助;作为共同完成人获得2020年教育部科学技术进步奖一等奖(抗真菌药物创新研发体系的建立与应用,8/18)。以第一/通讯(含共同)在药学专业期刊发表抗真菌相关SCI论文24篇,申请专利20项,授权并转化专利3项。
近三年发表SCI论文情况
Tingjunhong Ni#, Yumeng Hao#, Zichao Ding#, Xiaochen Chi, Fei Xie, Ruina Wang, Junhe Bao, Lan Yan, Liping Li, Ting Wang*, Dazhi Zhang*, and Yuanying Jiang*. Discovery of a Novel Potent Tetrazole Antifungal Candidate with High Selectivity and Broad Spectrum. Journal of Medicinal Chemistry, 2024, 67: 6238-6252.
Xianru Li#, Liping Li#, Haonan Zhang#, Xiaochen Chi, Yuanying Jiang*, Tingjunhong Ni*. Discovery of novel thiosemicarbazone derivatives with potent and selective anti-Candida glabrata activity. Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38 (1): 2202362
Liping Li#, Hao Wu#, Shuo Zhu, Zhe Ji, Xiaochen Chi, Fei Xie, Yumeng Hao, Hui Lu, Feng Yang, Lan Yan, Dazhi Zhang*, Yuanying Jiang*, Tingjunhong Ni*. Discovery of Novel 7-Hydroxy-5-oxo-4,5-dihydrothieno[3,2-b]pyridine-6-carboxamide Derivatives with Potent and Selective Antifungal Activity against Cryptococcus Species. Journal of Medicinal Chemistry, 2022, 65 (16): 11257-11269.
Liping Li#, Hao Wu#, Jiayin Wang#, Zhe Ji, Ting Fang, Hui Lu, Lan Yan, Fuming Shen, Dazhi Zhang*, Yuanying Jiang*, Tingjunhong Ni*. Discovery of novel 8-hydroxyquinoline derivatives with potent in vitro and in vivo antifungal activity. Journal of Medicinal Chemistry, 2023, 66 (23): 16364-16376.
Tingjunhong Ni#, Xiaochen Chi#, Hao Wu#, Fei Xie, Junhe Bao, Jiayin Wang,Zhe Ji, Liping Li, Xiaobo Wang, Lan Yan, Yumeng Hao*, Dazhi Zhang*, Yuanying Jiang*. Design, synthesis and evaluation of novel deferasirox derivatives with high antifungal potency in vitro and in vivo. European Journal of Medicinal Chemistry, 2024, 264: 116026.
Fei Xie#, Yumeng Hao#, Yu Liu#, Junhe Baoa, Ruina Wanga, Xiaochen Chic, Ting Wanga, Shichong Yua, Yongsheng Jina, Liping Lib, Yuanying Jiangb, Dazhi Zhang*, Lan Yan*, Tingjunhong Ni*. From Synergy to Monotherapy: Discovery of Novel 2,4,6-Trisubstituted Triazine Hydrazone Derivatives with Potent Antifungal Potency In Vitro and In Vivo. Journal of Medicinal Chemistry, 2024, 67, 4007-4025
Tingjunhong Ni#, Zichao Ding#, Fei Xie#, Yumeng Hao, Junhe Bao, Jingxiang Zhang, Shichong Yu*, Yuanying Jiang*, Dazhi Zhang*. Design, synthesis, and in vitro and in vivo antifungal activity of novel triazoles containing phenylethynyl pyrazole side chains. Molecules, 2022, 27: 3370.
Fei Xie#, Yumeng Hao#, Liping Li#, Ruina Wang, Junhe Bao, Xiaochen Chi, Brian C. Monk, Ting Wang, Shichong Yu, Yongsheng Jin, Dazhi Zhang*, Tingjunhong Ni*, Lan Yan*. Novel antifungal triazoles with alkynyl-methoxyl side chains: Design, synthesis, and biological activity evaluation. European Journal of Medicinal Chemistry, 2023, 257: 115506.
Fei Xie#, Yumeng Hao#, Junhe Bao#, Jiacun Liu, Yu Liu, Ruina Wang, Xiaochen Chi, Xiaoyun Chai, Ting Wang, Shichong Yu, Yongsheng Jin, Lan Yan*, Dazhi Zhang*, Tingjunhong Ni*. Design, synthesis, and in vitro evaluation of novel antifungal triazoles containing substituted 1, 2, 3-triazole-methoxyl side chains. Bioorganic Chemistry, 2022, 129: 106216.
Xiaochen Chi#, Fei Xie#, Liping Li#, Yumeng Hao, Hao Wu, Xianru Li, Guangxin Xia, Lan Yan, Dazhi Zhang*, Yuanying Jiang*, Tingjunhong Ni*. Discovery of novel triazoles containing benzyloxy phenyl isoxazole side chain with potent and broad-spectrum antifungal activity. Bioorganic Chemistry, 2023, 137: 106572.
Tingjunhong Ni, Fei Xie, Yumeng Hao, Liping Li, Shuo Zhu, Hao Wu, Xiaochen Chi, Lan Yan, Yuanying Jiang*, Dazhi Zhang*. Discovery of Novel Orally Bioavailable Triazoles with Potent and Broad-Spectrum Antifungal Activity In Vitro and In Vivo. Journal of Medicinal Chemistry, 2022, 65 (24): 16665-16678.
Tingjunhong Ni#, Xiaochen Chi#, Fei Xie#, Liping Li, Hao Wu, Yumeng Hao, Xiaobo Wang*, Dazhi Zhang*, Yuanying Jiang*. Design, Synthesis, and Evaluation of Novel Tetrazoles Featuring Isoxazole Moiety as Highly Selective Antifungal Agents. European journal of medicinal chemistry, 2023, 246: 115007.
Xiaochen Chi#, Haonan Zhang#, Hao Wu#, Xianru Li, Liping Li*, Yuanying Jiang*, Tingjunhong Ni*. Discovery of novel tetrazoles featuring a pyrazole moiety as potent and highly selective antifungal agents. ACS omega, 2023, 8 (19): 17103-17115.
Tingjunhong Ni#, Fei Xie#, Liping Li#, Yumeng Hao, Xiaochen Chi, Lan Yan, Dazhi Zhang*, Yuanying Jiang*, Quanzhen Lv*. Design, synthesis and structure-activity relationship studies of nicotinamide derivatives as potent antifungal agents by disrupting cell wall. Molecules, 2023, 28: 1135.
近三年专利情况:
倪廷峻弘, 姜远英. 一种噻唑酰肼类衍生物及其制备方法和应用. 2023-08-15, 中国, ZL202010716661.X.
倪廷峻弘, 姜远英,张大志,迟晓晨,季喆. 苯并噻唑腙类化合物的抗真菌应用. 2024-02-07, 中国, CN202410175054.5.
倪廷峻弘, 姜远英,张大志,李立平. 一种噻吩骈吡啶酮类化合物、制备方法及一种抗真菌药物. 2023-11-28, 中国, ZL202110276862.7.
李立平, 倪廷峻弘, 伍浩,姜远英. 一种新型喹啉衍生物在制备抗真菌药物中的应用. 2023-03-06, 中国, CN202310205537.0.
谢斐, 郝雨濛, 倪廷峻弘, 阎澜, 金永生, 汪亭, 俞世冲, 暴军合, 王瑞娜, 刘昱, 迟晓晨, 夏广新, 余建鑫, 张春春, 张大志. 三嗪腙类化合物、其制备、含其的药物组合物及其应用, 2024-02-01, CN202410144909.8.
谢斐, 郝雨濛, 张大志, 暴军合, 阎澜, 姜远英, 倪廷峻弘, 丁子超, 刘昱, 刘佳存, 李立平. 一种取代三氨基三嗪类化合物的制备方法及其应用, 2022-09-07, 中国, CN202211089783.6.
倪廷峻弘, 姜远英, 张大志, 迟晓晨, 李立平. 一种氮唑醇类化合物、制备方法以及一种抗真菌药物. 2022-11-25,中国,CN202211488800.3.
张大志, 姜远英, 倪廷峻弘, 蔡瞻, 由守谊, 仰振球, 齐东绮. 一种三氮唑醇类衍生物及其制备方法和应用, 2017-12-5, 中国, ZL201510106679.7.
倪廷峻弘, 姜远英,张大志. 一种四氮唑醇类化合物、制备方法以及一种抗真菌药物. 2021-04-19, 中国, CN202110416875.X.
倪廷峻弘, 姜远英, 张大志, 迟晓晨, 李立平. 一种氮唑醇类化合物、制备方法以及一种抗真菌药物. 2023-03-06,中国, CN202310205535.1.
倪廷峻弘, 姜远英, 张大志, 迟晓晨. 一种四氮唑醇类化合物、制备方法及其应用. 2023-06-15,中国, CN202310709459.8.
倪廷峻弘, 阎澜, 谢斐, 张春春, 余建鑫, 姜远英, 夏广新, 朱愈斐, 郝雨濛, 弓雪莲, 苗琦, 田萧萧, 王瑞娜, 丁子超, 暴军合, 刘佳存, 张大志. 一种杂芳环类化合物及其应用. 2023-02-28, 中国, CN202310178917.X.
倪廷峻弘, 张春春, 阎澜, 谢斐, 余建鑫, 姜远英, 夏广新, 暴军合, 王瑞娜, 刘佳存, 苗琦, 田萧萧, 郝雨濛, 丁子超, 张大志. 苯并[d][1,3]二氧杂环戊烯类化合物、制备方法及其应用. 2023-02-28, 中国, CN202310178916.5.