血管侵犯与肝癌转移的机制研究（Mechanism study of vascular invasion and metastasis of hepatocellular carcinoma）
上海市东方医院，美高梅高等研究院，副研究员（Shanghai East Hospital, Institute of Advanced Study of Tongji University, Associate professor）
【主持省部级及以上科研项目】
（1）国家自然科学基金青年项目，82203741，微管解聚蛋白STMN1调控p-EMT过程促进早期肝癌微血管侵犯的作用与机制，2023.01-2025.12.31，30万（课题负责人）
National Natural Science Foundation of China (82203741), The role and mechanism of STMN1 in promoting microvascular invasion of early hepatocellular carcinoma through p-EMT process. 2023.01-2025.12.31
（2）上海市2022年度“科技创新行动计划”医学创新研究专项，22Y11908500，早期肝癌微血管侵犯诊断标志物的建立与应用，2022.07.01-2025.06.30，30万（课题负责人）
The Project of Shanghai Science and Technology Commission (22Y11908500), Establishment and application of diagnostic markers for microvascular invasion in early hepatocellular carcinoma, 2022.07.01-2025.06.30
【代表性文章】
1. Cai YC#, Fu Y#, Liu CC#, Wang XC#, You P, Li XH, Song YX, Mu XN, Jiang D, Yang Y, Gu YY, Zhang HB*, He ZY*. Stathmin 1 is a biomarker for diagnosis of microvascular invasion to predict prognosis of early hepatocellular carcinoma. Cell Death & Disease 2022; 13(2): 176. (IF: 9.685)
2. Cheng Z#, He ZY#, Cai YC#, Zhang C#, Fu GB, Li HY, Sun W, Liu CC, Cui XL, Ning BF, Xiang DM, Zhou TF, Li XF, Xie WF, Wang HY*, Ding J*. Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors. Cell Research 2019; 29(2): 124-135. #Co-first authors. (IF: 20.507).
3. Fu GB#; Huang WJ#; Zeng M#; Zhou X#; Wu HP#; Liu CC; Wu H; Weng J; Zhang Hd; Cai YC; Ashton C; Ding M; Tang D; Zhang BH; Gao Y; Yu WF; Zhai B*; He ZY*; Wang HY*; Yan HX*. Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens. Cell Research 2019; 29(1):8-22
4. Wang C#; Chen WJ#; Wu YF#; You P#; Zheng SY; Liu CC; Xiang D; Wang MJ; Cai YC; Zhao QH; Uyunbilig B; Liu W; Xiong WJ; Kirk JW; Wang X; Liu ZM*; He ZY*. The extent of liver injury determines hepatocyte fate toward senescence or cancer. Cell Death and Disease 2018, 9(5):575
