霉菌毒素、重金属等环境污染物暴露对人皮肤和肠道的毒理分子机制及潜在干预措施
Toxicological molecular mechanisms and potential interventions in human skin and gut by exposure to environmental pollutants such as mycotoxins and heavy metals
以第一作者/通讯作者在Ecotoxicology and environmental safety、Biomedicine & Pharmacotherapy、Toxins和Journal of Functional Foods等杂志发表SCI论文13篇，影响因子累计达57.5；同时发表EI论文1篇、中文核心期刊4篇。
作为项目负责人先后主持国家自然科学基金青年项目1项、上海市“科技创新行动计划”自然科学基金面上项目1项，上海市卫生健康委员会科研项目面上项目，上海市皮肤病医院学术骨干项目1项，参与国自然面上项目1项，在研科研经费累计90万元。
As the first author, she has published 13 SCI in the Journals such as Ecotoxicology and environmental safety, Toxins and Journal of applied toxicology, with a cumulative impact factor of 57.5. At the same time, she published one study in EI journal and four studies in Chinese core journals.
As the project leader, she has hosted one National Natural Science Foundation Youth project, one Shanghai Science and Technology Innovation Action Plan Natural Science Foundation project, one Shanghai Municipal Health Commission’s General Project, one academic backbone project of Shanghai Skin Disease Hospital, and participated one National Natural Science Foundation project. The current research funding has reached to RMB 900,000.
Publications:
[1] Chen Jiashe, Zhou Zhiyu, Wu Nanhui, Li Jie, Xi Ningyuan, Xu Mingyuan, Wu Fei, Fu Qiaoting, Yan Guorong, Liu Yeqiang, Xu Xiaoxiang. Chlorogenic acid attenuates deoxynivalenol-induced apoptosis and pyroptosis in human keratinocytes via activating Nrf2/HO-1 and inhibiting MAPK/NF-κB/NLRP3 pathways. Biomedicine & Pharmacotherapy. 2024, 170:116003.
[2] Liu Mengjie, Yan Guorong, Chang Juan, Wang Ping, Liu Chaoqi, Yin Qingqiang, Xu Xiaoxiang. Compound probiotics and glycyrrhizic acid alleviate DON-induced liver damage linked to the alteration of lipid metabolism in piglets. Journal of Functional Foods. 2024, 106390.
[3] Xu Xiaoxiang, Chang Juan, Wang Ping, Liu Chaoqi, Liu Mengjie, Zhou Ting, Yin Qingqiang, Yan Guorong. Combination of glycyrrhizic acid and compound probiotics alleviates deoxynivalenol-induced damage to weaned piglets. Ecotoxicology and environmental safety. 2023, 256:114901.
[4] Xu Xiaoxiang, Xi Ningyuan, Chen Jiashe, Zhou Zhiyu, Liu Mengjie, Yan Guorong, Liu Yeqiang. Deoxynivalenol exposure induces oxidative stress and apoptosis in human keratinocytes via PI3K/Akt and MAPK signaling pathway. Environmental Toxicology. 2023 Sep 13.
[5] Jiang Long #, Xu Xiaoxiang#, Yan Guorong, Wu Yuhao, Xi Ningyuan, Lai Yongxian, Zhang Guolong, Liu Yeqiang. Untargeted metabolomics yields insight into extramammary Paget's disease mechanisms. Front Oncol. 2024 Jan 29;14:1319819.
[6] Xu Xiaoxiang, Chang Juan, Wang Ping, Liu Chaoqi, Liu Mengjie, Zhou Ting, Yin Qingqiang, Yan Guorong. Glycyrrhizic Acid and Compound Probiotics Supplementation Alters the Intestinal Transcriptome and Microbiome of Weaned Piglets Exposed to Deoxynivalenol. Toxins (Basel). 2022, 14(12):856.
[7] Xu Xiaoxiang, Chang Juan, Wang Ping, Liu Chaoqi, Zhou Ting, Yin Qingqiang, Yan Guorong. Glycyrrhinic acid and probiotics alleviate deoxynivalenol-induced cytotoxicity in intestinal epithelial cells. AMB Express. 2023, 13(1):52. （JCR 2区，IF=3.7）
[8] Xiaoxiang Xu; Juan Chang; Ping Wang; Qingqiang Yin; Chaoqi Liu; Maolong Li; Andong Song; Qun Zhu; Fushan Lu. Effect of chlorogenic acid on alleviating inflammation and apoptosis of IPEC-J2 cells induced by deoxyniyalenol. Ecotoxicology and environmental safety, 2020，205:1-9. （中科院毒理学1区，IF=6.3）
[9] Xiaoxiang Xu, Guorong Yan, Juan Chang, et al. Comparative transcriptome analysis reveals protective mechanism of glycyrrhinic acid for deoxynivalenol-induced inflammation and apoptosis in IPEC-J2 cells. Oxidative medicine and cellular longevity, 2020, 2020:1-17.
[10] Xiaoxiang Xu, Yingjia Wei, Mian Khaqan Shah, et al. Effects of compound active peptides on protecting liver and intestinal epithelial cells from damages and preventing hyperglycemia. Oxidative medicine and cellular longevity, 2020, 2020:1-11.
[11] Xiaoxiang Xu, Guorong Yan, Juan Chang, et al. Astilbin ameliorates deoxynivalenol-induced oxidative stress and apoptosis in intestinal porcine epithelial cells (IPEC-J2). Journal of applied toxicology, 2020, 40:1362-1372.
[12] Xu Xiaoxiang, Yang Canyu, Chang Juan, Wang Ping, Yin Qingqiang, Liu Chaoqi, Gao Tianzeng, Dang Xiaowei, Lu Fushan. Dietary Supplementation with Compound Probiotics and Berberine Alters Piglet Production Performance and Fecal Microbiota. Animals (Basel). 2020 Mar 19;10(3):511.
[13] Xiaoxiang Xu, Zhongping Yin, Jiguang Chen, et al. De Novo Transcriptome assembly and annotation of the leaves and callus of Cyclocarya paliurus (Bata1) Iljinskaja. Plos one，2016 年 8 月，IF=3.059 (JCR 2 区);
[14] 许小向等，青钱柳鲨烯合成酶(CpSS)全长基因的克隆、分析与表达，中国食品学报(EI)，2020;
[15] 许小向等，火炬松松针多糖提取工艺及其抗氧化性研究，林产化学与工业，2016;
[16] 许小向等，松针多糖微波提取工艺及抗氧化性研究，食品工业科技，2015;
[17] 许小向等，松针多糖的提取工艺及稳定性研究，食品科技，2015;
[18] 许小向等，红巧梅花色苷树脂静态纯化工艺研究，江西农业大学学报，2015。
以第一作者/通讯作者在Ecotoxicology and environmental safety、Biomedicine & Pharmacotherapy、Toxins和Journal of Functional Foods等杂志发表SCI论文13篇，影响因子累计达57.5；同时发表EI论文1篇、中文核心期刊4篇。
作为项目负责人先后主持国家自然科学基金青年项目1项、上海市“科技创新行动计划”自然科学基金面上项目1项，上海市卫生健康委员会科研项目面上项目，上海市皮肤病医院学术骨干项目1项，参与国自然面上项目1项，在研科研经费累计90万元。
As the first author, she has published 13 SCI in the Journals such as Ecotoxicology and environmental safety, Toxins and Journal of applied toxicology, with a cumulative impact factor of 57.5. At the same time, she published one study in EI journal and four studies in Chinese core journals.
As the project leader, she has hosted one National Natural Science Foundation Youth project, one Shanghai Science and Technology Innovation Action Plan Natural Science Foundation project, one Shanghai Municipal Health Commission’s General Project, one academic backbone project of Shanghai Skin Disease Hospital, and participated one National Natural Science Foundation project. The current research funding has reached to RMB 900,000.
Publications:
[1] Chen Jiashe, Zhou Zhiyu, Wu Nanhui, Li Jie, Xi Ningyuan, Xu Mingyuan, Wu Fei, Fu Qiaoting, Yan Guorong, Liu Yeqiang, Xu Xiaoxiang. Chlorogenic acid attenuates deoxynivalenol-induced apoptosis and pyroptosis in human keratinocytes via activating Nrf2/HO-1 and inhibiting MAPK/NF-κB/NLRP3 pathways. Biomedicine & Pharmacotherapy. 2024, 170:116003.
[2] Liu Mengjie, Yan Guorong, Chang Juan, Wang Ping, Liu Chaoqi, Yin Qingqiang, Xu Xiaoxiang. Compound probiotics and glycyrrhizic acid alleviate DON-induced liver damage linked to the alteration of lipid metabolism in piglets. Journal of Functional Foods. 2024, 106390.
[3] Xu Xiaoxiang, Chang Juan, Wang Ping, Liu Chaoqi, Liu Mengjie, Zhou Ting, Yin Qingqiang, Yan Guorong. Combination of glycyrrhizic acid and compound probiotics alleviates deoxynivalenol-induced damage to weaned piglets. Ecotoxicology and environmental safety. 2023, 256:114901.
[4] Xu Xiaoxiang, Xi Ningyuan, Chen Jiashe, Zhou Zhiyu, Liu Mengjie, Yan Guorong, Liu Yeqiang. Deoxynivalenol exposure induces oxidative stress and apoptosis in human keratinocytes via PI3K/Akt and MAPK signaling pathway. Environmental Toxicology. 2023 Sep 13.
[5] Jiang Long #, Xu Xiaoxiang#, Yan Guorong, Wu Yuhao, Xi Ningyuan, Lai Yongxian, Zhang Guolong, Liu Yeqiang. Untargeted metabolomics yields insight into extramammary Paget's disease mechanisms. Front Oncol. 2024 Jan 29;14:1319819.
[6] Xu Xiaoxiang, Chang Juan, Wang Ping, Liu Chaoqi, Liu Mengjie, Zhou Ting, Yin Qingqiang, Yan Guorong. Glycyrrhizic Acid and Compound Probiotics Supplementation Alters the Intestinal Transcriptome and Microbiome of Weaned Piglets Exposed to Deoxynivalenol. Toxins (Basel). 2022, 14(12):856.
[7] Xu Xiaoxiang, Chang Juan, Wang Ping, Liu Chaoqi, Zhou Ting, Yin Qingqiang, Yan Guorong. Glycyrrhinic acid and probiotics alleviate deoxynivalenol-induced cytotoxicity in intestinal epithelial cells. AMB Express. 2023, 13(1):52. （JCR 2区，IF=3.7）
[8] Xiaoxiang Xu; Juan Chang; Ping Wang; Qingqiang Yin; Chaoqi Liu; Maolong Li; Andong Song; Qun Zhu; Fushan Lu. Effect of chlorogenic acid on alleviating inflammation and apoptosis of IPEC-J2 cells induced by deoxyniyalenol. Ecotoxicology and environmental safety, 2020，205:1-9. （中科院毒理学1区，IF=6.3）
[9] Xiaoxiang Xu, Guorong Yan, Juan Chang, et al. Comparative transcriptome analysis reveals protective mechanism of glycyrrhinic acid for deoxynivalenol-induced inflammation and apoptosis in IPEC-J2 cells. Oxidative medicine and cellular longevity, 2020, 2020:1-17.
[10] Xiaoxiang Xu, Yingjia Wei, Mian Khaqan Shah, et al. Effects of compound active peptides on protecting liver and intestinal epithelial cells from damages and preventing hyperglycemia. Oxidative medicine and cellular longevity, 2020, 2020:1-11.
[11] Xiaoxiang Xu, Guorong Yan, Juan Chang, et al. Astilbin ameliorates deoxynivalenol-induced oxidative stress and apoptosis in intestinal porcine epithelial cells (IPEC-J2). Journal of applied toxicology, 2020, 40:1362-1372.
[12] Xu Xiaoxiang, Yang Canyu, Chang Juan, Wang Ping, Yin Qingqiang, Liu Chaoqi, Gao Tianzeng, Dang Xiaowei, Lu Fushan. Dietary Supplementation with Compound Probiotics and Berberine Alters Piglet Production Performance and Fecal Microbiota. Animals (Basel). 2020 Mar 19;10(3):511.
[13] Xiaoxiang Xu, Zhongping Yin, Jiguang Chen, et al. De Novo Transcriptome assembly and annotation of the leaves and callus of Cyclocarya paliurus (Bata1) Iljinskaja. Plos one，2016 年 8 月，IF=3.059 (JCR 2 区);
[14] 许小向等，青钱柳鲨烯合成酶(CpSS)全长基因的克隆、分析与表达，中国食品学报(EI)，2020;
[15] 许小向等，火炬松松针多糖提取工艺及其抗氧化性研究，林产化学与工业，2016;
[16] 许小向等，松针多糖微波提取工艺及抗氧化性研究，食品工业科技，2015;
[17] 许小向等，松针多糖的提取工艺及稳定性研究，食品科技，2015;
[18] 许小向等，红巧梅花色苷树脂静态纯化工艺研究，江西农业大学学报，2015。
