长期从事关于缺血性疾病的促血管新生疗法的基础与临床转化研究,目前以第一作者或通讯作者身份发表SCI论文7篇,参与其余论著共计十余篇,作为项目负责人主持国家自然科学基金1项,美高梅青年人才培育优青项目1项,参编心血管病专著1本。
Li is expert in the angiogenic treatment of ischemic diseases and critical diseases. On basis of these findings, he hosts 2 research grants, including National Nature Science Foundation of China, Program for Young Excellent Talents in Tongji University, Fundamental Research Funds for the Central Universites. Her representative publications appear in prestigious journals as first or corresponding author including 7 SCI papers.以第一作者或通讯作者发表的代表性论著:
(1) Rui-Lin Li#, Jing-Juan Huang#, Yi-Qin Shi#, An Hu, Zhao-Yang Lu, Liang Weng, Shen-Qi Wang, Yi-Peng Han, Lan Zhang*, Chang-Ning Hao*, Jun-Li Duan*,Pulsed electromagneticfield improves postnatal neovascularization in response to hindlimb ischemia,Am J Transl Res. 2015; 7(3): 430–444.
(2)Rui-Lin Li#, Zhao-Yang Lu#, Jing-Juan Huang#, Jia Qi, An Hu, Zhi-Xiao Su, Lan Zhang, Yue Li*, Yi-Qin Shi*, Chang-Ning Hao*, Jun-Li Duan*,SRT1720, a SIRT1 specific activator, protected H2O2-induced senescent endothelium.Am J Transl Res. 2016; 8(7): 2876–2888.
(3)Zhao-Yang Lu#, Rui-Lin Li#, Hong-Sheng Zhou, Jing-Juan Huang, Zhi-Xiao Su, Jia Qi, Lan Zhang, Yue Li*, Yi-Qin Shi*, Chang-Ning Hao*, Jun-Li Duan*, Therapeutic ultrasound reverses peripheral ischemia in type 2 diabetic mice through PI3K-Akt-eNOS pathway .Am J Transl Res. 2016; 8(9): 3666–3677.
(4)Zhao-Yang Lu#, Rui-Lin Li#, Hong-Sheng Zhou#, Jing-Juan Huang, Jia Qi, Zhi-Xiao Su, Lan Zhang, Yue Li*, Yi-Qin Shi*, Chang-Ning Hao*, Jun-Li Duan*, Rescue of hypertension-related impairment of angiogenesis by therapeutic ultrasound. Am J Transl Res. 2016; 8(7): 3087–3096.
(5)Huang JJ#, Shi YQ#, Li RL#, Hu A*, Lu ZY, Weng L, Han YP, Wang SQ, Zhang L* , Hao CN* and Duan JL*, Therapeutic ultrasound protects HUVECs from ischemia/hypoxia-induced apoptosis via the PI3K-Akt pathway. Am J Transl Res. 2017 Apr 15;9(4):1990-1999.
(6)Cheng-Hui Fan#, Ying Hao#, Yong-Hua Liu, Xiao-Lin Li, Zhen-Hao Huang, Yu Luo*, Rui-Lin Li*, Anti-inflammatory effects of rosuvastatin treatment on coronary artery ectasia patients of different age groups. BMC Cardiovasc Disord. 2020; 20: 330.
(7)Rui-Lin Li#, Shu-Guang Chu, Yu Luo, Zhen-Hao Huang, Ying Hao, Cheng-Hui Fan*, Atypical presentation of SARS-CoV-2 infection: A case report. World J Clin Cases. 2020 Apr 6; 8(7): 1265–1270.主持科研项目情况:
1. 国家自然科学基金青年基金,81801379,脉冲电磁场通过激活HuR调控 Sirt1/eNOS 信号通路改善老年鼠血管老化的作用及机制研究
Pulsed electromagnetic field prevents vascular aging in aged mice by up-regulating Sirt1/eNOS signaling pathway in a HuR-dependent fashion. China National Natural Science Foundation (81801379)
2.美高梅青年人才培育优青项目,PA2018001538,脉冲电场磁场通过激活HuR/Sirt1/eNOS信号通路改善衰老血管内皮细胞功能障碍的机制研究
Pulsed electromagnetic field improves dysfunction of senescent vascular endothelial cells by up-regulating HuR/Sirt1/eNOS signaling pathway in a HuR-dependent fashion. Program for Young Excellent Talents in Tongji University, Fundamental Research Funds for the Central Universites (22120180600).