血管损伤修复，冠心病心衰机制研究Mechanism and therapeutic approach study of vascular injury repair, coronary artery diseases and heart failure

美高梅附属上海东方医院律失常教育部重点实验室和转化中心的课题组长
辅助59599aa美高梅病理生理学科研究生教学
担任上海市病理生理协会理事，中国高血压联盟第六届理事会理事，中国医师协会高血压专业委员会第三届委员会委员

张玉珍教授作为一名医学科研工作者，在美国长期致力于基础医学科学研究的同时也希望把实验室的发现应用到临床，从事动脉粥样硬化、血管损伤修复、脂质代谢和心肺发育的研究，以第一作者在Nat Genet、J Clin Invest、Circulation、Genes & Dev和Development 等国际权威杂志上发表文章，总影响因子近100分，被广泛引用，同时以优异成绩通过了美国医生资格考试 (United States Medical Licensing Examination，USMLE)，掌握了扎实的专业知识和前沿研究技术，积累的丰富的科研经验。2012年回国后主持国家重大科学基础研究计划（973）课题分课题组长，国家自然科学基金，上海浦江人才，血管稳态与重构的调控机制重大研究计划培育项目，主要参与国家自然科学基金国际合作和创新团体，从事血管损伤修复、再生、重塑，冠心病动脉粥样硬化形成和发展机制以及干细胞分裂机制的研究，以通讯作者在Circulation，Circulation research，Arterioscler Thromb Vasc Biol, Theranostics等权威杂志上发表文章。除科研以外致力于心血管疾病预防，与影像科心血管科合作收集冠脉造影病人样本库，分析冠状动脉斑块与心血管危险因素关系，为临床早期筛查高危人群提供有价值的依据；与社区合作建立老年人心血管疾病样本库，随访5年以上体检老年人，干预心血管可控危险因素，以参与者获的上海市科学进步二等奖, 以通讯作者在Aging Diseases, J Cell Mol Med等杂志发表文章。

主持科研项目：

1. 获得今年申请自然科学基金面上项目，血管平滑肌细胞WISP2通过结合功能分子调节细胞增殖迁移影响损伤新生内膜增生形成的作用和机制研究

2. 自然科学基金面上项目，81770259，转录因子Foxp1在压力超负荷致心室重构中的作用和机制研究 2018/01-2021/12

3. 国家自然科学基金重大研究计划培育项目，91639112，Foxp1介导IL-b/Lox-1调节内皮细胞/单核巨噬细胞交互作用 在动脉粥样硬化发生发展中作用2017/01-2019/12

4. 国家重点基础研究计划-973项目，2014CB965100，人胚胎干细胞衍生细胞治疗心肌梗死后心力衰竭的关键科学问题研究(多模态评估临床前hESCs衍生细胞移植安全性、有效性和功能整合，2014/01-2018/08，骨干

5. 国家重点基础研究计划--973项目，2012CB966800，“干细胞分裂模式和干细胞干性维持的机制研究”之分课题“miRNA和蛋白质修饰在干细胞对称/不对称分裂过程中的作用及机理”，2012/01-2016/08，已结题，课题组长

6. 国家自然科学基金面上项目，81170116，“Gata6对血管损伤修复和动脉粥样硬化形成的作用及其机制”，2012/01-2015/12，已结题

7. 上海市浦江人才计划，13PJ1407000，“Foxp1调控巨噬细胞极性/可塑性与动脉粥样硬化的形成发展”，2013/01-2015/01，已结题

参与课题：1. 国际重大合作交流项目，81120108004，“心脏离子通道蛋白胞膜定向运输机制研究”，2012/01-2016/12，已结题

2. 国家创新研究群体科学基金项目，81221001，“心律失常发生机制研究”，2013/01- 2015/12，已结题

主要发表文章：

2019

1.Zhuang T, Liu J, Chen X, Zhang L, Pi J, Sun H, Li L, Bauer RC, Wang H, Yu Z, Zhang Q, Tomlinson B, Chan P, Zheng X, Morrisey E, Liu Z, Reilly M, Zhang Y. Endothelial Foxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 Inflammasome Activation. Circ Res. 2019 Jul 18. doi: 10.1161/CIRCRESAHA.118.314402. [Epub ahead of print] (Corresponding author) IF 15.862

Nature Reviews Cardiology chief editor research highlights IF 17.421

2.Liu J, Zhuang T, Pi J, Chen X, Zhang Q, Li Y, Wang H, Shen Y, Tomlinson B, Chan P, Yu Z, Cheng Y, Zheng X, Reilly M, Morrisey E, Zhang L, Liu Z, Zhang Y. Endothelial Foxp1 Regulates Pathological Cardiac Remodeling Through TGF-β1-Endothelin-1 Signal Pathway. Circulation. 2019 Jun 10. doi: 10.1161/CIRCULATIONAHA.119.039767. [Epub ahead of print] (Corresponding author) IF 23.054

3.Zhuang T, Liu J, Chen X, Pi J, Kuang Y, Wang Y, Tomlinson B, Chan P, Zhang Q, Li Y, Yu Z, Zheng X, Reilly M, Morrisey E, Zhang L, Liu Z, Zhang Y. Cell-Specific Effects of GATA (GATA Zinc Finger Transcription Factor Family)-6 in Vascular Smooth Muscle and Endothelial Cells on Vascular Injury Neointimal Formation. Arterioscler Thromb Vasc Biol. 2019 May;39(5):888-901. doi: 10.1161/ATVBAHA.118.312263 (Corresponding author) IF 6.618

4.Wang Y, Liu J, Chen X, Sun H, Peng S, Kuang Y, Pi J, Zhuang T, Zhang L, Yu Z, Tomlinson B, Chan P, Chen Y, Zhang Y, Li Y. Dysfunctional endothelial-derived microparticles promote inflammatory macrophage formation via NF-кB and IL-1β signal pathways. J Cell Mol Med. 2019 Jan;23(1):476-486. doi: 10.1111/jcmm.13950. Epub 2018 Oct 18. (Corresponding author) IF 4.658

5.Chan P, Shao L, Tomlinson B, Zhang Y, Liu ZM. An evaluation of pitavastatin for the treatment of hypercholesterolemia. Expert Opin Pharmacother. 2019 Jan;20(1):103-113. doi: 10.1080/14656566.2018.1544243. Epub 2018 Nov 27. Review. (Co-author)

6.Tao M, Pi X, Ma X, Shi Y, Zhang Y, Gu H, Chi Y, Zhuang S , Liu N. Relationship between serum uric acid and clustering of cardiovascular disease risk factors and renal disorders among Shanghai population: a multicentre and cross-sectional study. BMJ Open. 2019 Mar 1;9(3):e025453. doi: 10.1136/bmjopen-2018-025453. (Co-author).

7.Zhuang R, Ge X, Han L, Yu P, Gong X, Meng Q, Zhang Y, Fan H4, Zheng L, Liu Z, Zhou X. Gut microbe-generated metabolite trimethylamine N-oxide and the risk of diabetes: A systematic review and dose-response meta-analysis. Obes Rev. 2019 Jun;20(6):883-894. doi: 10.1111/obr.12843. Epub 2019 Mar 13. Review. (Co-author)

2018

1.Pi J, Liu J, Zhuang T, Zhang L, Sun H, Chen X, Zhao Q, Kuang Y, Peng S, Zhou X, Yu Z, Tao T, Tomlinson B, Chan P, Tian Y, Fan H, Liu Z1, Zheng X, Morrisey E, Zhang Y. Elevated Expression of miR302-367 in Endothelial Cells Inhibits Developmental Angiogenesis via CDC42/CCND1 Mediated Signaling Pathways. Theranostics 2018; 8(6): 1511-1526. (Corresponding author) IF 8.063

2.Yuan J, Hu Z, Mahal BA, Zhao SD, Kensler KH, Pi J, Hu X, Zhang Y, Wang Y, Jiang J, Li C, Zhong X, Montone KT, Guan G, Tanyi JL, Fan Y, Xu X, Morgan MA, Long M, Zhang Y, Zhang R, Sood AK, Rebbeck TR, Dang CV, Zhang L. Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers. Cancer Cell. 2018 Oct 8;34(4):549-560.e9. (Co-author) IF 23.916

3.Chan P, Shao L, Tomlinson B, Zhang Y, Liu ZM. Metformin transporter pharmacogenomics: insights into drug disposition-where are we now? Expert Opin Drug Metab Toxicol. 2018 Nov;14(11):1149-1159. doi: 10.1080/17425255.2018.1541981. Epub 2018 Nov 13. Review. (Co-author)

2017

1.Pi J, Tao T, Zhuang T, Sun H, Chen X, Liu J, Cheng Y, Yu Z, Zhu HH, Gao WQ, Suo Y, Wei X, Chan P, Zheng X,Tian Y, Morrisey E, Zhang L, Zhang Y. A MicroRNA- 302-367-Erk1/2-Klf2-S1pr1 Pathway Prevents Tumor Growth via Restricting Angiogenesis and Improving Vascular Stability. Circulation Research. 2017 Jan 6; 120(1):85-98.(corresponding author) IF 15.862

2.Peng S, Shen T, Liu J, Tomlinson B, Sun H, Chen X, Paul Chan, Kuang Y, Zheng L, Wu H, Ding X, Qian D, Shen Y, Gao P, Fan H, Liu Z, Zhang Y. Uncontrolled Hypertension Increases with Age in an Older Community-Dwelling Chinese Population in Shanghai. Aging Dis. 2017 Oct 1;8(5):558-569. (Corresponding author) IF 5.058

3.Shao X, Ding Z, Zhao M, Liu K, Sun H, Chen J, Liu X, Zhang Y, Hong Y, Li H, Li H. Mammalian Numb protein antagonizes Notch by controlling postendocytic trafficking of the Notch ligand Delta-like 4. J Biol Chem. 2017 Dec 15;292(50):20628-20643. doi: 10.1074/jbc.M117.800946. Epub 2017 Oct 17. (Co-author)

4.Tomlinson B, Hu M, Zhang Y, Chan P, Liu ZM. Liraglutide for weight management: benefits and risks. Curr Med Res Opin. 2017 Jan 4:1-3. (Co-author)

2016

1.Kuang Y, Li X, Chen X, Sun H, Tomlinson B, Chan P, Zheng L, Pi J, Peng S, Wu H, Ding X, Qian D, Shen Y, Yu Z, Fan L,Chen M, Fan H, Liu Z, Zhang Y. Higher prevalence of elevated LDL-C than non-HDL-C and low statin treatment rate in elderly community-dwelling Chinese with high cardiovascular risk. Sci Rep. 2016 Sep 30;6:34268. doi: 10.1038/srep34268. (Corresponding author)

2.Fan H, Li X, Zheng L, Chen X, Lan Q, Wu H, Ding X, Qian D, Shen Y, Yu Z, Fan L, Chen M, Tomlinson B, Chan P, Zhang Y, Liu Z. Abdominal obesity is strongly associated with Cardiovascular Disease and its Risk Factors in Elderly and very Elderly Community-dwelling Chinese. Sci Rep. 2016 Feb 17; 6:21521. doi: 10.1038/srep21521. (Corresponding author)

3.Tomlinson B, Hu M, Zhang Y, Chan P, Liu ZM. Effects of glucose-lowering drugs on cardiovascular outcomes in patients with type 2 diabetes. Expert Opin Drug Metab Toxicol. 2016 Sep 19:1-5. (Co-author)

4.Tomlinson B, Hu M, Zhang Y, Chan P, Liu ZM. An overview of new GLP-1 receptor agonists for type 2 diabetes. Expert Opin Investig Drugs. 2016 Feb;25(2):145-58. (Co-author)

2015

1.Liang D, Li J, Wu Yahan, Zhen LX, Li CM, Qi M, Wang LJ, Deng F, Huang J, Lv F, Liu Y, Ma XE, Yu ZR, Zhang YZ, Chen YH. miRNA-204 drives cardiomyocyte Proliferation via targeting Jarid2. Int J Cardiol. 2015; 201: 38-48. (Co-author)

2.Zheng L, Lan Q, Zhang Y, Feng J, Wang G, Li X, Kang S, Li J, Fan H, Liu Z. The screening value of baPWV and hs-crp to ASCVD in middle and elderly community population in Shanghai. Int J Cardiol. 2015;186:289-90. (Co-author)

2014

1.Liang D, Xu X, Deng F, Feng J, Zhang H, Liu Y, Zhang Y, Pan L, Liu Y, Zhang D, Li J, Liang X, Sun Y, Xiao J, Chen YH. miRNA-940 reduction contributes to human Tetralogy of Fallot development. J Cell Mol Med. 2014; 18(9): 1830-1839. (Co-author)

2.Shi D, Xie D, Zhang H, Zhao H, Huang J, Li C, Liu Y, Lv F, The E, Liu Y, Yuan T, Wang S, Chen J, Pan L, Yu Z, Liang D, Zhu W, Zhang Y, Li L, Peng L, Li J, Chen YH. Reduction in dynamin-2 is implicated in ischaemic cardiac arrhythmias. J Cell Mol Med. 2014; 18(10): 1992-1999. (Co-author)

2013

1.Yu Z, Wang L, Wang C, Ju X, Wang M, Chen K, Loro E, Li Z, Zhang Y, Wu K, Casimiro MC, Gormley M, Ertel A, Fortina P, Chen Y, Tozeren A, Liu Z, Pestell RG. Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer. Nat Commun. 2013;4:2812. (Co-author)

2.Li J, Xu L, Ye J, Li X, Zhang D, Liang D, Xu X, Qi M, Li C, Zhang H, Wang J, Liu Y, Zhang Y, Zhou Z, Liang X, Li J, Peng L, Zhu W, Chen YH. Aberrant dynamin 2-dependent Na(+) /H(+) exchanger-1 trafficking contributes to cardiomyocyte apoptosis. J Cell Mol Med. 2013; 17(9): 1119-1127. (Co-author)

2012 Li S, Wang Y, Zhang Y, Lu MM, DeMayo FJ, Dekker JD, Tucker PW, Morrisey EE. Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2. Development. 2012 Jul; 139(14):2500-9. (Co-author)

2011

1.Tian Y, Zhang Y, Hurd L, Hannenhalli S, Liu F, Lu MM, Morrisey EE. Regulation of lung endoderm progenitor cell behavior by miR302/367. Development. 2011 Apr;138(7):1235-45. (Co-author)

2.Anokye-­Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, Zhang Y, Yang W, Gruber PJ, Epstein JA, and Morrisey EE. Highly efficient miRNA mediated reprogramming of somatic cells to induced pluripotent stem cells. Cell Stem Cell 2011 April; 8:376–388. (Co-author)

2010

1.Zhang Y, McGillicuddy FC, Hinkle CC, O