主持课题:
美高梅自主原创基础研究项目,2022/11-2024/10,15万,BISPR参与MSC调节小胶质细胞促进帕金森病治疗的作用及机制研究
上海市同济医院优秀青年人才计划,杰出青年项目,2022-2025,30万
国家自然科学基金面上项目,2022-2025,55万 ,组蛋白H3K27me3修饰在MSC抑制神经炎症治疗帕金森病中的作用和机制研究
国家自然科学基金青年科学基金项目,2017-2019, 17万,基于单细胞转录组分析的多因子动员神经干细胞促进脑缺血损伤修复的机制研究
美高梅青年优秀人才培养行动计划项目,2018-2019,5万,炎症因子预处理人脐带间充质干细胞对缺血性脑损伤的疗效及其作用机制的单细胞水平研究
发表文章:
1: Tong W, Zhang K, Yao H, Li L, Hu Y, Zhang J, Song Y, Guan Q, Li S, Sun YE, Jin L. Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulated in Exercise in a Mouse Model of Parkinson's Disease. Front Aging Neurosci. 2022 Jun 23;14:891644.
2: Zhang C#, Zhou L#, Wang Z, Gao W, Chen W, Zhang H, Jing B, Zhu X, Chen L, Zheng C, Shi K, Wu L, Cheng L, Zhang K*, Sun YE*. Eradication of specific donor-dependent variations of mesenchymal stem cells in immunomodulation to enhance therapeutic values. Cell Death Dis. 2021 Apr; 6;12(4):357.
3: Li M#, Zhao W, Wang Y, Jin L, Jin G, Sun X, Wang W, Wang K, Xu X, Hao J, Jin R, Fu W, Sun Y, Chang Y, Huang X, Zhou X, Wu H*, Zhang K*, Ge Q*. A wave of Foxp3+ regulatory T cell accumulation in the neonatal liver plays unique roles in maintaining self-tolerance. Cell Mol Immunol. 2020 May;17(5):507-518.
4: Hu Y#, Zhang K#, Zhang T, Wang J, Chen F, Qin W, Tong W, Guan Q, He Y, Gu C, Chen X, Kang UJ, Sun YE, Li S, Jin L. Exercise Reverses Dysregulation of T-Cell-Related Function in Blood Leukocytes of Patients With Parkinson's Disease. Front Neurol. 2020 Jan 28;10:1389.
5: Huang Y#, Li Q#, Zhang K#, Hu M, Wang Y, Du L, Lin L, Li S, Sorokin L, Melino G, Shi Y*, Wang Y*. Single cell transcriptomic analysis of human mesenchymal stem cells reveals limited heterogeneity. Cell Death Dis. 2019 May 8;10(5):368.
6: Liu J#, Zhang KS#, Hu B, Li SG, Li Q, Luo YP, Wang Y*, Deng ZF*. Systematic Analysis of RNA Regulatory Network in Rat Brain after Ischemic Stroke. Biomed Res Int. 2018 Jan 8;2018:8354350.
7: Wang H#, Zhang K#, Liu Y, Fu Y, Gao S, Gong P, Wang H, Zhou Z, Zeng M, Wu Z, Sun Y, Chen T, Li S*, Liu L*. Telomere heterogeneity linked to metabolism and pluripotency state revealed by simultaneous analysis of telomere length and RNA-seq in the same human embryonic stem cell. BMC Biol. 2017 Dec 8;15(1):114.
8: Zhang K#, Huang K, Luo Y, Li S*. Identification and functional analysis of long non-coding RNAs in mouse cleavage stage embryonic development based on single cell transcriptome data. BMC Genomics. 2014 Oct 3;15(1):845.7.
9: Liu H#, Chen Y#, Niu Y#, Zhang K#, Kang Y, Ge W, Liu X, Zhao E, Wang C, Lin S, Jing B, Si C, Lin Q, Chen X, Lin H, Pu X, Wang Y, Qin B, Wang F, Wang H, Si W, Zhou J, Tan T, Li T, Ji S, Xue Z, Luo Y, Cheng L, Zhou Q, Li S*, Sun YE*, Ji W*. TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys. Cell Stem Cell. 2014 Mar 6;14(3):323-328.