1. Macromolecule self-assembly

2. Cell surface engineering

3. Cell carrier

Awards:

2016 the Youth Hundred Plan, Tongji University

2012 Shanghai Phosphor Youth Science and technology talent program

2011 the Talents Plan, Tongji University

the Dawn Plan, Shanghai Municipal Education Committee

Excellent graduate tutor Award, School of Nanometer, Tongji University

2010 Excellent Research Award, School of Nanometer, Tongji University

Excellent Doctoral Thesis Award, Hubei province

58Yan Li, Lianghua He, Haiqing Dong, Yiqiong Liu, Kun Wang, Ang Li, TianbinRen, Donglu Shi, Yongyong Li*. Fever-inspired Immunotherapy Based on Photothermal CpG Nanotherapeutics: The Critical Role of Mild Heat in Regulating Tumor Microenvironment, Advanced Science. (IF=9.03, In revision)

57 Kun Wang, Shuman Wen, Lianghua He, Ang Li, Yan Li, Haiqing Dong, Wei Li, Tianbin Ren, Donglu Shi, Yongyong Li*. ‘Minimalist’ Nanovaccine Constituted with Near Whole Antigen for Potent Cancer Immunotherapy, ACS Nano. (IF=13, In revision)

56 Xiaomei Xue, Xueyin Shi, Haiqing Dong, Shasha You, Huimin Cao, Kun Wang, Ya Wen, Donglu Shi, Bin He*, Yongyong Li*, Delivery of MicroRNA-1 Inhibitor by Dendrimer-based Nanovector: an Early Targeting Therapy for Myocardial Infarction in Mice, Nanomedicine: Nanotechnology, Biology, and Medicine. (IF=5.8, Accept)

55 Huiyun Wen, Haiqing Dong*, Jie Liu, Aijun Shen, Yongyong Li*, Donglu Shi, Redox-mediated dissociation of PEG–polypeptidebased micelles for on-demand release of anticancer drugs, 2016, J. Mater. Chem B, 4, 7859-7869. (IF=4.543)

http://pubs.rsc.org/-/content/articlehtml/2016/tb/c6tb02364a

54 Junping Ma, Haiqing Dong, Haiyan Zhu, Cheuk-Wing Li, Yongyong Li*and Donglu Shi, Deposition of gadolinium onto the shell structure of micelles for integrated magnetic resonance imaging and robust drug delivery systems, J. Mater. Chem. B, 2016, 4, 6094. (IF=4.543)

http://pubs.rsc.org/en/content/articlehtml/2016/tb/c6tb01013j

53 Dou Du, Kun Wang, Ya Wen, Yan Li, Yongyong Li*, Photodynamic Graphene Quantum Dot: Reduction Condition Regulated Photo-activity and Size Dependent Efficacy, ACS Appl Mater Interfaces. 2016, 3287-3294. (IF=7.504)

http://pubs.acs.org/doi/full/10.1021/acsami.5b11154

52 Yan Li, Zhiyong Wu, Dou Du, Haiqing Dong, Donglu Shi, Yongyong Li*, A Graphene Quantum Dot (GQD) Nanosystem with Redox-Triggered Cleavable PEG Shell Facilitating Selective Activation of Photosensitiser for Photodynamic Therapy, Rsc Advances. 2016, 6, 6516-6522. (IF=3.108)

http://pubs.rsc.org/en/content/articlehtml/2016/ra/c5ra23622c

51 Ya Wen, Haiqing Dong, Yan Li, Aijun Shen, and Yongyong Li*, Nano-assembly of bovine serum albumin driven by rare-earth-ion (Gd) biomineralization for highly efficient photodynamic therapy and tumor imaging, J. Mater. Chem. B, 2016, 4, 743-751. (IF=4.543)

http://pubs.rsc.org/en/content/articlehtml/2016/tb/c5tb01962a

50 Yan Li, Haiqing Dong, Yongyong Li*, Single-protein-based theranostic nanosystem within sub-10 nm scale for tumor imaging and therapy, Rsc Advances. 2015, 5, 73752-73759 (IF=3.108)

http://pubs.rsc.org/en/content/articlehtml/2015/ra/c5ra12648g

49 Yongyong Li, et al. Supramolecular, Prodrug-based Micelles with Enzyme Regulated Release Behavior for Controlled Drug Delivery, MedChemComm, 2015, 6, 1874-1881. (IF=2.608)

http://pubs.rsc.org/en/content/articlehtml/2015/md/c5md00299k

48 Xiaojun Cai, Yongyong Li*, Reversible PEGylation and Schiff-base linked imidazole modification of polylysine for high-performance gene delivery. J Mat Chem B. 2015, 3, 1507-1517. (IF=4.543)

http://pubs.rsc.org/en/content/articlehtml/2015/tb/c4tb01724b

47 Haiqing Dong H, Min Tang, Yongyong Li*, Donglu Shi. Disulfide-bridged cleavable PEGylation in polymeric nanomedicine for controlled therapeutic delivery. Nanomedicine. 2015;10:1941-58. (IF=4.727)

https://www.futuremedicine.com/doi/10.2217/nnm.15.38

46 Jiashan Zhoui, Yongyong Li* et al, Effect of monomer sequence of poly(histidine/lysine) catiomers on gene packing capacity and delivery efficiency, Rsc Advances. 2015, 5, 14138-46. (IF=3.108)

http://pubs.rsc.org/en/content/articlehtml/2015/ra/c4ra13785j

45 Yan Li, Haiqing Dong, Donglu Shi*, Yongyong Li*. Graphene-based Nano-vehicles for Photodynamic Medical Therapy. International Journal of Nanomedicine, 2015, 10, 2451. (IF:4.3)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383220/

44 Yan Li, Haiqing Dong, Xuequan Li, Donglu Shi, Yongyong Li*. Single polymer–drug conjugate carrying two drugs for fixed-dose co-delivery. Medicinal Chemistry, 2014, 4, 672-683. (IF:2.331)

https://www.omicsonline.org/open-access/single-polymerdrug-conjugate-carrying-two-drugs-for-fixeddose-codelivery-2161-0444.1000676.php?aid=31092

43 Xiaojun Cai, Haiyan Zhu, Haiqing Dong, Jiansheng Su, Yongyong Li*, and Donglu Shi∗,Suppression of VEGF by Reversible-PEGylated Histidylated Polylysine in Cancer Therapy, Advanced Healthcare Materials, 2014, 3, 1818–1827. (IF=5.11)

http://onlinelibrary.wiley.com/doi/10.1002/adhm.201400063/full

42 Haiqing Dong, Chunyan Dong, Tianbin Ren, Yongyong Li*, and Donglu Shi*, Surface-Engineered Graphene-Based Nanomaterials for Drug Delivery, J. Biomed. Nanotechnol. 2014, 10, 10, 2086–2106. (IF=4.521)

http://chinesesites.library.ingentaconnect.com/content/asp/jbn/2014/00000010/00000009/art00018

41 Zhu Haiyan,, Dong Chunyan, Dong Haiqing, Ren Tianbin, Wen Xuejun, Su Jiansheng, Li Yongyong*, Cleavable PEGylation and Hydrophobic Histidylation of Polylysine for siRNA Delivery and Tumor Gene Therapy. ACS Appl Mater Interfaces. 2014, 6, 10393-407. (IF=7.504)

http://pubs.acs.org/doi/10.1021/am501928p

40 Dong HQ, Dong CY, Xia WJ, Li yongyong*, Ren TB, Self-assembled, Redox-sensitive, H-shaped Pegylated Methotrexate Conjugates with High Drug-carrying Capability for Intracellular Drug Delivery, MedChem Comm, 2014, 5, 147, 152. (IF=2.608)

http://pubs.rsc.org/en/content/articlehtml/2014/md/c3md00267e

39 Li Yongyong, Liu JQ, Dong HQ, Liu GZ, Hu HQ, Engineering of a Pluronic F127 functionalized magnetite/graphene nanohybrid for chemophototherapy, Nanotechnology, 2014, 25, 065602. (IF=3.44)

http://iopscience.iop.org/article/10.1088/0957-4484/25/6/065602/meta

38 Yongyong Li*, Junping Ma, Haiyan Zhu, Xiaolong Gao, Haiqing Dong, and Donglu Shi, Green Synthetic, Multifunctional Hybrid Micelles with Shell Embedded Magnetic Nanoparticles for Theranostic Applications, ACS Appl. Mater. Interfaces 2013, 5, 7227-7235. (IF=7.504)

http://pubs.acs.org/doi/10.1021/am401573b

37 Yongyong Li, Lan Li, Haiqing Dong , Xiaojun Cai, Tianbin Ren, Pluronic F127 nanomicelles engineered with nuclear localized functionality for targeted drug delivery, Mater Sci Eng C 2013, 33, 2698-2707. (IF=4.164)

http://www.sciencedirect.com/science/article/pii/S0928493113001367?via%3Dihub

36 Tianbin Ren, Wenjuan Xia, Wei Wu, Yongyong Li*, Stimuli-Responsive and Polymeric Prodrugs, Progress in chemistry, 2013, 25, 775-784.（IF=0.953）

http://manu56.magtech.com.cn/progchem/CN/abstract/abstract11083.shtml

35 Meng Chu, Chunyan Dong, Haiyan Zhu, Xiaojun Cai, Haiqing Dong, Tianbin Ren, Jiansheng Su and and Yongyong Li*, Biocompatible polyethylenimine-graft-dextran catiomer for highly efficient gene delivery assisted by a nuclear targeting ligand, Poly. Chem., 2013, 3, 2561-2569. (IF=5.375)

http://pubs.rsc.org/en/content/articlehtml/2013/py/c3py21092h

34 Xiaojun Cai, Haiqing Dong, Junping Ma, Haiyan Zhu, Wei Wu, Meng Chu, Yongyong Li* and Donglu Shi* Effects of spatial distribution of the nuclear localization sequence on gene transfection in catiomer–gene polyplexes, J. Mater. Chem. B, 2013, 1, 1712-1721. (IF=4.543)

http://pubs.rsc.org/en/content/articlehtml/2013/tb/c3tb00425b

33 Tianbin Ren, Lan Li, Xiaojun Cai, Haiqing Dong, Shumeng Liu and Yongyong Li*, Engineered polyethylenimine/graphene oxide nanocomposite for nuclear localized gene delivery, Polym. Chem., 2012, 3, 2561-2569. (IF=5.375)

http://pubs.rsc.org/en/content/articlehtml/2012/py/c2py20343j

32 Aijun Shen, Dongliang Li, Xiaojun Cai, Chunyan Dong, Haiqing Dong, Huiyun Wen, Peijun Wang, Yongyong Li*, Multifunctional nanocomposite based on graphene oxide for in vitro hepatocarcinoma diagnosis and treatment, Journal of Biomedical Materials Research, 2012,100, 2499-506. (IF=3.076)

http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.34148/full

32 Haiqing Dong, Chunyan Dong, Yue Feng, Tianbin Ren, Zhonghai Zhang, Lan Li and Yongyong Li*, Engineering of peglayted camptothecin into core–shell nanomicelles for improving solubility, stability and combination delivery, MedChemComm, 2012, 3, 1555-1561. (IF=2.608)

http://pubs.rsc.org/en/content/articlehtml/2012/md/c2md20153d

31 Haiqing Dong, Yongyong Li*, Jin Yu, Yanyan Song, Xiaojun Cai, Jiaqiang Liu, Jiaming Zhang, RC Ewing, Donglu Shi*, A Versatile Multi-Component Assembly via β-cyclodextrin Host-Guest Chemistry on Graphene for Biomedical Applications, Small, 2013, 9,446-456. (IF=8.643)

http://onlinelibrary.wiley.com/doi/10.1002/smll.201201003/full

30 Yanna Cui, Haiqing Dong, Xiaojun Cai, Deping Wang, and Yongyong Li*, Mesoporous Silica Nanoparticles Capped with Disulfide-Linked PEG Gatekeepers for Glutathione-Mediated Controlled Release, ACS Appl. Mater. Interfaces, 2012, 4, 3177-3183. (IF=7.504)

http://pubs.acs.org/doi/10.1021/am3005225

29 Xiaojun Cai, Chunyan Dong, Haiqing Dong, Gangmin Wang, Giovanni M. Pauletti, Xiaojing Pan, Huiyun Wen, Isaac Mehl, Yongyong Li* and Donglu Shi, Effective Gene Delivery Using Stimulus-responsive Catiomer Designed with Redox-sensitive Disulfide and Acid-labile Imine Linkers, Biomacromolecules, 2012, 13, 1024-1034. (IF=5.246)

http://pubs.acs.org/doi/full/10.1021/bm2017355

28 Hui-Yun Wen, Chunyan Dong, Haiqing Dong, Aijun Shen, Wenjuan Xia, Xiaojun Cai, Yanyan Song, Xuequan Li, Yongyong Li* and Donglu Shi, Engineered Redox-Responsive PEG Detachment Mechanism in PEGylated Nano-graphene Oxide for Intracellular Drug Delivery, Small, 2012, 8, 760-769. (IF=8.643)

http://onlinelibrary.wiley.com/doi/10.1002/smll.201101613/full

27 Hai-Qing Hu, Jin-Hai Yu, Jian Zhao, Hai-Qing Dong, Yongyong Li*, Engineering of a Novel Pluronic F127/Graphene Nanohybrid for pH Responsive Drug Delivery, Journal of Biomedical Materials Research, 2012, 100, 141-8. (IF=2.834)

http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.33252/full

26 Xiao-Jun Cai, Hai-Qing Dong, Wen-Juan Xia, Hui-Yun Wen, Xue-Quan Li, Jin-Hai Yu, Yongyong Li* and Dong-Lu Shi, Glutathione-mediated Shedding of PEG Layers Based on Disulfide-Linked Catiomers for DNA Delivery, Journal of Materials Chemistry, 2011, 21, 14639-14645. (IF=4.543)

http://pubs.rsc.org/en/content/articlehtml/2011/jm/c1jm11693b

25 Xue-Quan Li, Hui-Yun Wen, Hai-Qing Dong, Wei-Ming Xuea, Giovanni M. Paulettic, Xiao-Jun Cai, Wen-Juan Xia, Donglu Shi and Yongyong Li*, Self-assembling Nanomicelles of a Novel Camptothecin Prodrug Engineered with a Redox-responsive Release Mechanism, Chem. Commun., 2011, 47, 8647-8649. (IF=6.319)

http://pubs.rsc.org/en/content/articlehtml/2011/cc/c1cc12495a

24 Tian-Bin Ren, Wen-Juan Xia, Hai-Qing Dong, Yongyong Li*, Sheddable micelles based on disulfide-linked hybrid PEG-polypeptide copolymer for intracellular drug delivery, Polymer, 2011, 52, 3580-3586. (IF=3.684)

http://www.sciencedirect.com/science/article/pii/S0032386111004873?via%3Dihub

23 Yong-Yong Li, Hai-Qing Dong, Yun Liu, Han Cheng, Cao Li, Wang Xiao, Cong Chang, Shou-Hu Hua, Xuan Zeng, Si-Xue Cheng, Xian-Zheng Zhang, Zhuo RX, Supramolecular polymer micelles prepared by steric effect tuned self-assembly: a new strategy for self-assembly, Soft Matter, 2011, 7, 4839-4844. (IF=3.889)

http://pubs.rsc.org/en/content/articlehtml/2011/sm/c1sm05438d

22 Tian-Bin Ren, Yue Feng, Zhong-Hai Zhang, Lan Li, Yongyong Li*, Shell-sheddable micelles based on star-shaped poly(ε-caprolactone)-SS-poly(ethyl glycol) copolymer for intracellular drug release. Soft Matter, 2011, 7, 2329-2331. （IF=3.889）

http://pubs.rsc.org/en/content/articlehtml/2011/sm/c1sm05020f

21 Hui-Yun Wen, Hai-Qing Dong, Wen-juan Xie, Yongyong Li*, Kang Wang, Giovanni M. Pauletti and Dong-Lu Shi, Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery. Chem. Commun., 2011, 47, 3550-3552. (IF=6.319)

http://pubs.rsc.org/en/content/articlehtml/2011/cc/c0cc04983b

20 Hai-Qing Dong, Yongyong Li*, Hui-Yun Wen, Meng Xu, Li-Jian Liu, Zhuo-Quan Li, Fang-Fang Guo, Dong-Lu Shi *, Highly Efficient Drug Delivery Nanosystem by L-Phenylalanine Triggering Based on Supramolecular Polymer Micelles. Macromolecular Rapid Communications, 2011, 32, 540-545. (IF=4.265)

http://onlinelibrary.wiley.com/doi/10.1002/marc.201000693/full

19 Yong-Yong Li, Shou-Hu Hua, Wang Xiao, Hui-Yuan Wang, Xiao-Hua Luo, Cao Li, Si-Xue Cheng, Xian-Zheng Zhang, and Ren-Xi Zhuo, Dual-Vectors of Anti-Cancer Drugs and Genes Based on pH-Sensitive Micelles Self-Assembled from Hybrid Polypeptide Copolymers. Journal of Materials Chemistry, 2011, 21, 3100-3106. (IF=4.543)

http://pubs.rsc.org/en/content/articlehtml/2011/jm/c0jm03385e

18 Hai-Qing Dong, Zhi-Lei Zhao, Hui-Yun Wen, Yong-Yong Li*, Ai-Jun Shen, Frank Pilger, Chao Lin, Dong-Lu Shi*, Poly(ethylene glycol) conjugated nano-graphene oxide for photodynamic therapy. Science in China, Series B-Chemistry, 2010, 53, 1-7.

https://link.springer.com/article/10.1007%2Fs11426-010-4114-9

17 Kang Wang, Hai-Qing Dong, Hui-Yun Wen, Meng Xu, Cao Li, Yong-Yong Li*, Helen N Jones, Dong-Lu Shi, Xian-Zheng Zhang, Novel vesicles self-assembled from amphiphilic star-armed PEG-polypeptide hybrid copolymers for drug delivery. Macromolecular Bioscience, 2010, 11, 65-71. (IF=3.238)

http://onlinelibrary.wiley.com/doi/10.1002/mabi.201000247/full

16 Tian-Bin Ren, Yue Feng, Hai-Qing Dong, Lan Li, Yong-Yong Li*,Sheddable Nanoparticles for Biomedical Application. Progress in Chemistry, 2011, 21, 213-220. (IF=0.953)

http://manu56.magtech.com.cn/progchem/CN/Y2011/V23/I01/213

15 Yong-Yong Li, Hai-qing Dong, Kang Wang, Xian-zheng Zhang, Dong-lu Shi, Stimulus-responsive polymeric nanoparticles for biomedical applications, Science in China, Series B-Chemistry, 2010, 53, 447-457.

https://link.springer.com/article/10.1007%2Fs11426-010-0101-4

14 Yong-Yong Li, Han Cheng, Jing-Ling Zhu et al. Temperature- and pH-sensitive multicolored micellar complexes. Advanced Materials, 2009, 21, 2402-2406. (IF=19.791)

http://onlinelibrary.wiley.com/doi/10.1002/adma.200803770/full

13 Yong-Yong Li, Jie Yang, Xian-Zheng Zhang et al. Degradable Nanogel as a Nanoreactor for Growing Silica Colloids. Langmuir, 2009, 25, 1923–1926. (IF=3.833)

http://pubs.acs.org/doi/full/10.1021/la803902r

12 Yong-Yong Li, Han Cheng, Zhi-Guo Zhang et al. Cellular internalization and in vivo tracking of thermosensitive luminescent micelles based on luminescent lanthanide chelate. ACS Nano, 2008, 2, 125-133. (IF=13.942)

http://pubs.acs.org/doi/full/10.1021/nn700145v

11 Hai-Qing Dong,* Yong-Yong Li* (共同第一作者), Shao-Jun Cai et al. A facile one-pot construction of supramolecular polymer micelles from a-cyclodextrin and poly(e-caprolactone). Angewandte Chemie International Edition, 2008, 47, 5573-5576. (IF= 11.994)

http://onlinelibrary.wiley.com/doi/10.1002/anie.200800952/full

10 Gwang-Chol Kim,* Yong-Yong Li* (共同第一作者), Yan-Feng Chu et al. Nanosized temperature-responsive Fe₃O₄-UA-g-P(UA-co-NIPAAm) magnetomicelles for controlled drug release. European Polymer Journal, 2008, 44, 2761-2767. (IF= 3.531)

http://www.sciencedirect.com/science/article/pii/S0014305708003261?via%3Dihub

9 Gwang-Chol Kim,* Yong-Yong Li* (共同第一作者), Yan-Feng Chu et al. A nanosized, thermo-sensitive drug carrier: self-assembled Fe₃O₄-OA-g-P(OA-co-NIPAAm) magnetomicelles. Journal of Biomaterials Science-Polymer Edition, 2008, 19, 1249–1259. (IF= 1.9)

http://www.tandfonline.com/doi/abs/10.1163/156856208785540109

8 Yong-Yong Li, Yu Dai, Xian-Zheng Zhang et al. The tuned-morphology studies of the complexes between poly(N-isopropylacrylamide)-b-poly(vinylpyridine) and poly(N-isopropylacrylamide-co-hydroxylethyl methacrylate)-b-poly(vinylphenol). Journal of Colloid and Interface Science, 2008, 328, 211-215. (IF= 4.233)

http://www.sciencedirect.com/science/article/pii/S0021979708010928?via%3Dihub

7 Yong-Yong Li, Xian-Zheng Zhang, Jing-Ling Zhu et al. Self-assembled, thermoresponsive micelles based on triblock PMMA-b-PNIPAAm-b-PMMA copolymer for drug delivery. Nanotechnology, 2007,18, Article no. 215605. (IF= 3.44)

http://iopscience.iop.org/article/10.1088/0957-4484/18/21/215605/meta

6 Yong-Yong Li, Xian-Zheng Zhang, Han Cheng et al. Fluorescent, thermo-responsive biotin-P(NIPAAm-co-NDAPM)-b-PCL micelles for cell-tracking and drug delivery. Nanotechnology, 2007, 18, Article no. 505101. (IF= 3.44)

http://iopscience.iop.org/article/10.1088/0957-4484/18/50/505101/meta

5 Yong-Yong Li, Xian-Zheng Zhang, Gwang-Chol Kim et al. Thermosensitive Y-shaped micelles of poly(oleic acid-Y-N-isopropylacrylamide) for drug delivery. Small, 2006, 2, 917–923. (IF= 8.643)

http://onlinelibrary.wiley.com/doi/10.1002/smll.200600041/full

4 Yong-Yong Li, Xian-Zheng Zhang, Han Cheng, et al. Novel stimuli-/pH- responsive micelle self-assembled from Y-shaped P(UA-Y-NIPAAm) copolymer for drug delivery. Biomacromolecules, 2006, 7, 2956-2960. (IF= 5.246)

http://pubs.acs.org/doi/full/10.1021/bm060080k

3 Yong-Yong Li, Xian-Zheng Zhang, Han Cheng, et al. Self-assembled, thermosensitive PCL-g-P(NIPAAm-co-HEMA) micelles for drug delivery. Macromolecular Rapid Communications, 2006, 27, 1913-1919. (IF= 4.265)

http://onlinelibrary.wiley.com/doi/10.1002/marc.200600521/full

2 Shou-Hu Hua, Yong-Yong Li, Yun Liu, Wang Xiao, Cao Li, Fu-Wei Huang, Xian-Zheng Zhang, Ren-Xi Zhuo, Self-assembled micelles based on PEG-polypeptide hybrid copolymers for drug delivery. Macromolecular Rapid Communication, 31, 81-86. (IF= 4.265)

http://onlinelibrary.wiley.com/doi/10.1002/marc.200900473/full

1 Han Cheng, Yong-Yong Li, Xian-Zheng Zhang et al. Protamine sulfate/poly(L-aspartic acid) polyionic complexes self-assembled via electrostatic attractions for combined delivery of drug and gene. Biomaterials, 2009, 30，1246-1253. (IF= 8.402)

http://www.sciencedirect.com/science/article/pii/S0142961208008715