The laboratory is the main experimental research base of the Digestive Diseases Institute and the clinical digestive disease center of Tongji University, with advanced equipment and equipment, including ABI 7900 fluorescent quantitative PCR system, gradient PCR and Backman GEXP gene analyzer and GE protein analysis system, BD Canto II flow cytometry, Leica automatic fluorescence microscopy and fluorescence imaging analyzer, microplate reader, eight channel physiological recorder, isolated organ perfusion instrument (Ussing Chamber) and analysis software, Leica frozen slicing machine, CO2 incubator, Bio Tek multi function analyzer, ultracentrifuge, refrigerated centrifuge and other various types of research equipment related to molecular and cell biology.
Education Background
1977-1980 Graduated from the Department of medicine, Zunyi Medical College
1982-1985 Master of Pathophysiology, Zunyi-Dalian medical school
1992-1993 Research on the medical school of Technical University of Munich, Germany (public pypo visit)
1997-1998 Research on the medical school of Technical University of Munich, Germany (high visit to the public school)
2003-2004 Doctorate degree of medicine, School of Medicine, Universität Leipzig
Positions Held
Once: Member of the Guidance Committee for basic medical and curriculum teaching in the Ministry of Education
Standing director of the Chinese Academy of pathophysiology
Chairman of the Chinese Institute of pathophysiology and digestion of Specialized Committee
Deputy director of the Shanghai Municipal Institute of pathology and physiology
Deputy director of the Shanghai Municipal Institute of Physiological Sciences
Present: Director of the Chinese Academy of pathophysiology
Vice director of the Chinese Institute of pathophysiology digest Specialized Committee
Deputy director of the Shanghai Municipal Institute of pathology and physiology
Member of Chinese Medical Doctor Association Standing Committee of the Specialized Committee
Standing Committee of Chinese Journal of Pathophysiology
Digestive diseases. In particular, the etiology and pathogenesis of acute pancreatitis, gastritis, enteritis and gastrointestinal motility disorders are studied
Awards:
8 science and technology achievement awards of the provincial level and department level
Shanghai Educational Award
The educational system in Shanghai City, "38 red banner pacesetter"
"Moral education" excellent teacher award in Tongji University
1. Ming-hua Cao, Yong-yu Li, Jing Xu, Ya-jing Feng, Xu-hong Lin, Kun Li, Tong Han, Chang-Jie Chen. Cannabinoid HU210 protects isolated rat stomach against impairment caused by serum of rats with experimental acute pancreatitis. PLoS ONE 7(12): e52921，2012.
2. Li, Kun; Feng, Jia-yan; Li, Yong-yu; Yuece, Birol; Lin, Xu-hong; Yu, Liang-ying; Li, Yan-na; Feng, Ya-jing; Storr, Martin. Anti-Inflammatory Role of Cannabidiol and O-1602 in Cerulein-Induced Acute Pancreatitis in Mice. Pancreas. 42（1）：123–129，2013.
3. Kun Li, Jakub Fichna, Rudolf Schicho, Dieter Saur, Mohammad Bashashati, Ken Mackie, Yongyu Li, Andreas Zimmer, Burkhard Göke, Keith A. Sharkey, and Martin Storr. A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice. Neuropharmacology. 71：255–263，2013.
4.Li K, Su W, Li M, Chen CJ, Li YY, Lai LY, Zhang MM, Liu SJ, Fichna J, Peng A, Hao CM, Gu Y, Lin SY. Acid loading stimulates rat glomerular mesangial cells proliferation through Na(+)-H (+) exchanger isoform 1 (NHE1)-dependent pathway. Naunyn Schmiedebergs Arch Pharmacol. 386(6)：563–569，2013.
5. Yong-Yu Li, Birol Yuece, Ming-Hua Cao, Xu-Hong Lin, Shuai Lv, Chang-Jie Chen, Stephanie Ochs, Andrej Sibaev, Elisabeth Deindl, Claus Schaefer, Martin Storr. Inhibition of p38/Mk2 signaling pathway improves the anti-inflammatory effect of WIN55 on mouse experimental colitis. Lab Invest. 93(3):322-333, 2013.
6. Feng Y, Li Y, Chen CQ, Lin X, Yang Y, Cai H, Lv Z, Cao M, Li K, Xu J, Li S, Jia Y. Inhibiting Roles of Berberine in Gut Movement of Rodents are Related to Activation of the Endogenous Opioid System. Phytother Res. 27(10): 1564–1571, 2013.
7. Yong-yu Li, Ming-hua Cao, Brigitte Goetz, Chun-qiu Chen, Ya-jing Feng, Chang-Jie Chen,Michael S. Kasparek, Andrej Sibaev, Martin Storr, Martin E. Kreis. The Dual Effect of Cannabinoid Receptor-1 Deficiency on the Murine Postoperative Ileus. PLoS ONE, 8(7): e67427, 2013.
8.LIN Xu-Hong, WANG Ya-Qiang, WANG Hui-Chao, REN Xue-Qun, LI Yong-Yu1, Role of endogenous cannabinoid system in the gut. Acta Physiologica Sinica, 65(4): 451–460，2013.
9.Yi-Zhen Zhang and Yong-Yu Li. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol 7; 20(1): 91-99，2014.
10.Chunqiu Chen, Zhen Yu, Yongyu Li, Jakub Fichna and Martin Storr. Effects of Berberine in the Gastrointestinal Tract — A Review of Actions and Therapeutic Implications. The American Journal of Chinese Medicine. 42(5): 1–18, 2014.
11.Cao MH, Xu J, Cai HD, Lv ZW, Feng YJ, Li K, Chen CQ, Li YY. p38 MAPK inhibition alleviates experimental acute pancreatitis in mice. Hepatobiliary Pancreat Dis Int. 14(1):101-6,2015.
12. Chen C, Li YY, Yu Z, Liu Z, Shi Y, Lewandowska U, Sobczak M, Fichna J, Kreis M.Platelet Activity in the Pathophysiology of Inflammatory Bowel Diseases. Curr Drug Targets. 16（3）：219-225,2015.
13. Lin X, Wang H, Li Y, Chen C, Feng Y, Fichna J. Cannabinoids Regulate Intestinal Motor Function and Electrophysiological Activity of Myocytes in Rodents. Arch Med Res. 46(6):439-447,2015.
14.Yong-Yu Li, Kun Li, Hong Yao, Xiao-Juan Xu, and Qiao-Lin Cai. Reform in teaching preclinical pathophysiology. Adv Physiol Educ 39: 254–258, 2015.
15. Ya-Jing Feng, Yong-Yu Li, Xu-Hong Lin, Kun Li, Ming-Hua Cao. Anti-inflammatory effect of cannabinoid agonist WIN55,212 on mouse experimental colitis is related to inhibition of p38MAPK. World J Gastroenterol. 22(43): 9515-9524,2016.
16.Sisi Lin, Yongyu Li, Li Shen, Ruiqin Zhang, Lizhi Yang, Min Li, Kun Li, Jakub Fichna. The Anti-Inflammatory Effect and Intestinal Barrier Protection of HU210 Differentially Depend on TLR4 Signaling in Dextran Sulfate Sodium-Induced Murine Colitis. Dig Dis Sci, 62(2):372-386.2017.
17.Gong X, Xu X, Lin S, Cheng Y, Tong J, Li Y. Alterations in biomechanical properties and microstructure of colon wall in early-stage experimental colitis. Experimental and therapeutic medicine. 2017;14(2):995-1000.
18. Sisi Lin, Yongyu Li, J Werner,A.V. Bazhin. Reactive Oxygen Species and Colorectal Cancer.J Cell Physiol. 2017 Dec 7. doi: 10.1002/jcp.26356. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/29215746
19.Sisi Lin, Ruiqin Zhang, Yongyu Li, et al. Alterations in the gut barrier and involvement of Toll-like receptor 4 in murine postoperative ileus. Neurogastroent Motil. (Received)
